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Exploring Bioactive Compounds in Foods and Nutrients for Human Health

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 30 April 2026 | Viewed by 612

Special Issue Editors


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Guest Editor
Graduate Program in Nutrition Sciences, Federal Fluminense University Niterói-Rio de Janeiro (RJ), Niterói 24033-900, RJ, Brazil
Interests: chronic kidney diseases; food as medicine; inflammation; oxidative stress; gut microbiota; mitochondria
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Department of Cardiopneumology, Faculty of Medicine of the University of São Paulo (FMUSP), University of São Paulo, São Paulo 01246-903, SP, Brazil
Interests: chronic kidney diseases; cardiovascular diseases; nutrition; bioactive compounds; inflammation; oxidative stress; gut microbiota

Special Issue Information

Dear Colleagues,

In the 5th century BC, Hippocrates, a physician, philosopher, and the man considered the father of medicine, said "Let food be thy medicine and medicine be thy food", a phrase which is used to this day. With the continuous evolution of science and technology, this statement has gained increasing relevance and scientific support.

Incorporating bioactive compounds into the diet by consuming foods such as fruits, vegetables, spices, fermented products, and propolis, among others, has emerged as a valuable nutritional strategy. These bioactive compounds include exogenous antioxidants which have anti-inflammatory properties. Furthermore, many of these bioactives are metabolized by the intestinal microbiota, aiding in its modulation and, consequently, promoting overall health. This Special Issue, "Exploring Bioactive Compounds in Foods and Nutrients for Human Health", seeks to bring together cutting-edge research that highlights the roles and health benefits of the bioactive compounds and nutrients found in food. We invite contributions that enhance our understanding of how diet can influence health through biochemical, physiological, and microbiological pathways.

Prof. Dr. Denise Mafra
Guest Editor

Dr. Livia Alvarenga
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic non-communicable diseases
  • bioactive compounds
  • nutrients
  • human health

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Published Papers (1 paper)

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Review

26 pages, 2695 KiB  
Review
Bioactive Compounds as Modulators of N-Formyl Peptide Signaling in Chronic Diseases
by Livia Alvarenga, Ludmila F. M. F. Cardozo, Márcia Ribeiro, Fernanda Kussi, Marta Esgalhado and Denise Mafra
Molecules 2025, 30(14), 2981; https://doi.org/10.3390/molecules30142981 - 16 Jul 2025
Viewed by 438
Abstract
In physiological situations involving cell damage, molecules derived from mitochondria or bacteria are produced. These molecules are known as N-formyl peptides and are detected by formyl peptide receptors (FPRs), which stimulate immune cells to migrate to the specific site of injury or infection. [...] Read more.
In physiological situations involving cell damage, molecules derived from mitochondria or bacteria are produced. These molecules are known as N-formyl peptides and are detected by formyl peptide receptors (FPRs), which stimulate immune cells to migrate to the specific site of injury or infection. Despite their initially beneficial effects on health, N-formyl peptides also contribute to the development or exacerbation of chronic non-communicable diseases. Therefore, understanding the metabolic pathways related to the involvement of N-formyl peptides and FPRs may increase our ability to regulate immune responses and precisely target FPRs with personalized strategies, offering a promising approach for the treatment of specific diseases. In this way, bioactive compounds in food may influence N-formyl peptides, interacting with the receptors either competitively or by inhibiting them, which affects the inflammatory response and oxidative reactions of cells. This review examines the pathways associated with forming N-formyl peptides, the activation of FPRs, and the roles of bioactive compounds in regulating N-formyl peptides. Full article
(This article belongs to the Special Issue Exploring Bioactive Compounds in Foods and Nutrients for Human Health)
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