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Bioactive Natural Products and Derivatives

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 191

Special Issue Editors


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Guest Editor
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
Interests: bioactive natural products; target isolation; total synthesis; alkaloids; diterpene

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Guest Editor
College of Pharmacy, Nankai University, Tianjin, China
Interests: bioactive natural products; small molecules; polysaccharides; terpenoids; applications

Special Issue Information

Dear Colleagues,

The natural world serves as a vast repository of chemical substances, harboring an abundance of bioactive natural products. These compounds have significant potential for applications in medicine, agriculture, and the food industry. In recent years, the field of bioactive natural products and their derivatives has witnessed substantial progress, driven by the continuous development of novel natural product discovery technologies and in-depth investigations into natural product structural modification and synthesis techniques.

This Special Issue will focus on the research progress in bioactive natural products and their derivatives, including the following areas:

New Natural Product Discovery: Presentation of newly identified bioactive natural products, including their origins, structures, and activities.

Natural Product Derivatives: Exploration of the methods of the structural modification and synthesis of natural products, as well as the biological activities, pharmacological effects, and application prospects of their derivatives.

Mechanisms of Action of Natural Products and Their Derivatives: Based on activity screening, investigation of the mechanisms of action of natural products and their derivatives, along with potential targets, to reveal the unique mechanisms of natural products.

New Methods and Technologies: Investigation of the innovative methods and technologies used in natural product discovery, structural elucidation, activity screening, and synthesis.

Applications: Demonstration of the application cases of bioactive natural products and their derivatives in medicine, agriculture, and food, as well as future development trends.

Prof. Dr. Xiaoxiao Huang
Prof. Dr. Yuanqiang Guo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • new natural product discovery
  • natural product derivatives
  • bioactivities and mechanisms of action of natural products
  • application
  • new methods and technologies

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Published Papers (1 paper)

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Research

18 pages, 3776 KiB  
Article
In Vitro Anti-Inflammatory Terpenoid Glycosides from the Seeds of Dolichos lablab
by Wei Zhang, Jingya Ruan, Jiaming Cheng, Yingying Wang, Yinuo Zheng, Minghao Lin, Yi Zhang and Tao Wang
Molecules 2025, 30(8), 1779; https://doi.org/10.3390/molecules30081779 - 15 Apr 2025
Viewed by 118
Abstract
To further explore the anti-inflammatory components of the seeds of Dolichos lablab L., a comprehensive phytochemical investigation was conducted using diverse chromatographic and spectrometric technologies, as well as chemical reactions. As a result, ten previously unreported terpenoid glycosides, namely dolilabterpenosides A, B, C [...] Read more.
To further explore the anti-inflammatory components of the seeds of Dolichos lablab L., a comprehensive phytochemical investigation was conducted using diverse chromatographic and spectrometric technologies, as well as chemical reactions. As a result, ten previously unreported terpenoid glycosides, namely dolilabterpenosides A, B, C1–C3, D, E, and F1–F3 (110), along with four known analogues (1114), initially identified from Dolichos genus, were obtained. In addition, the lipopolysaccharide (LPS)-induced RAW264.7 cell model was employed to detect the expression levels of nitric oxide (NO), inflammatory cytokines tumour necrosis factor (TNF)-α and interleukin (IL)-1β to assess the anti-inflammatory activities of the obtained compounds. The results of bioactive assay showed that compounds 1, 47, and 1012 showed significant inhibitory activity on NO release in RAW264.7 cells in a dose-dependent manner, and all of them were demonstrated to inhibit the increase in TNF-α and IL-Iβ levels in the supernatant of RAW264.7 cells stimulated by LPS. Full article
(This article belongs to the Special Issue Bioactive Natural Products and Derivatives)
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