Special Issue "Microfluidics for Cells and Other Organisms, Volume II"

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology".

Deadline for manuscript submissions: 31 March 2020.

Special Issue Editor

Dr. Danny van Noort
E-Mail Website
Guest Editor
Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping 581 83, Sweden
Interests: microfluidics; 3D cell cultures; human-on-a-chip; lab automation; biomedical engineering
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Special Issue Information

Dear Colleagues,

I would like to invite you to submit your research on cells and other organisms in microfluidics. Microfluidics-based devices play an important role in creating realistic microenvironments in which cell cultures can thrive. They can, for example, be used to monitor drug toxicity and perform medical diagnostics, and be in a static-, perfusion- or droplet-based device. They can also be used to study cell-cell, cell-matrix or cell-surface interactions. Cells can be either single cells, 3D cell cultures or co-cultures. Other organisms could include bacteria, zebra fish embryo, C. elegans, to name a few. In addition, research contributions on plant cells and plants in microfluidics are encouraged. However, we will not be considering cancer models, as that will be the subject for a separate Special Issue in Bioengineering later on.

This Special Issue will give you the opportunity to publish work that has not fully matured yet, but is worthwhile to be brought to the attention of other researchers and readers of the journal.

Dr. Danny van Noort
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Microfluidics
  • Bacteria
  • Cells
  • Cell Cultures
  • Tissue
  • Organisms

Published Papers (1 paper)

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Research

Open AccessArticle
Determination of the Membrane Transport Properties of Jurkat Cells with a Microfluidic Device
Micromachines 2019, 10(12), 832; https://doi.org/10.3390/mi10120832 - 29 Nov 2019
Abstract
The Jurkat cell is an immortalized line of human acute lymphocyte leukemia cells that is widely used in the study of adoptive cell therapy, a novel treatment of several advanced forms of cancer. The ability to transport water and solutes across the cell [...] Read more.
The Jurkat cell is an immortalized line of human acute lymphocyte leukemia cells that is widely used in the study of adoptive cell therapy, a novel treatment of several advanced forms of cancer. The ability to transport water and solutes across the cell membrane under different temperatures is an important factor for deciding the specific protocol for cryopreservation of the Jurkat cell. In this study we propose a comprehensive process for determination of membrane transport properties of Jurkat cell. using a novel microfluidic controlled single cell-trapping system. The osmotic behavior of an individual Jurkat cell to water and dimethyl sulfoxide (DMSO), a commonly used cryoprotective agent (CPA), under constant temperature, was recorded under a microscope utilizing the modified microfluidic system. The images of the Jurkat cell under osmotic change were processed to obtain a relationship between cell volume change and time. The experimental results were fitted using a two-parameter transport numeric model to calculate the Jurkat cell membrane permeability to water and DMSO at room temperature (22 °C). This model and the calculated parameters can help scientists optimize the cryopreservation protocol for any cell type with optimal cryoprotective agents and cooling rate for future experiments. Full article
(This article belongs to the Special Issue Microfluidics for Cells and Other Organisms, Volume II)
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