Special Issue "Regulation of Immunity and Inflammation by Immunometabolites and Metabolic Enzymes"
Deadline for manuscript submissions: 31 August 2020.
Interests: immunometabolism; inflammation; autoimmunity; T cell biology
Interests: immunometabolism; macrophage biology; innate immunity
Interests: Innate immunity; Macrophages; Innate lymphoid cells; Immunometabolism
Special Issues and Collections in MDPI journals
Interests: immunometabolism, inflammation, innate immunity, inflammasomes, signalling in immune cells
Immunology and metabolism have long been viewed as two very distinct fields with minimal or no overlap. However, over the past decade, a fast-growing number of high-impact papers highlighted the intricate link between immune cell metabolism and function. The activation and effector functions of adaptive and innate immune cells are indeed governed by the engagement and modulation of specific intracellular metabolic pathways. Systemic metabolic cues and dysfunctions can also influence how immune cells work, supporting the concept that metabolism and inflammation are tightly connected. For example, metabolites are much more than intermediate or end products of metabolism. We now know that “immunometabolites” like succinate, itaconate, acetyl-CoA, and 2-hydroxyglutarate serve as signal transducers that regulate immune cell function and disease outcome. Moreover, metabolic enzymes such as glyceraldehyde-3-phospahte dehydrogenase (GAPDH) and pyruvate kinase (PK) do much more than converting one metabolite into another.
The scope of this Special Issue will be to update our current knowledge on how metabolites and metabolic enzymes can modulate immunity and inflammation. We welcome high-quality original research articles, as well as reviews and perspectives, that provide new mechanistic insight into the metabolic regulation of immune cells (macrophages, dendritic cells, monocytes, granulocytes, T cells, NK cells, B cells, etc.), and how this affects health and disease. Manuscripts describing new methods developed to investigate metabolite-mediated signalling pathways and the non-canonical role of metabolic enzymes in inflammation are also welcome.
Dr. Stefano Angiari
Dr. Jan Van den Bossche
Dr. Stanley Huang
Prof. Luke O'Neill
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- metabolic reprogramming
- immune cell heterogeneity and plasticity
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Metabolomic profiling reveals distinct and interactive effects of diet and inflammation in shaping systemic metabolism in LDLR -/- mice
Authors: Mario A. Lauterbach, Anette Christ and Eicke Latz
Abstract: Changes in modern dietary habits such as consumption of western type diets affect physiology on several levels including metabolism, inflammation and the gut microbiome. It is currently unclear whether changes in systemic metabolism due to dietary interventions are of long-lasting nature and how they potentially affect acute inflammatory processes. Here we investigated how western diet (WD) feeding altered systemic metabolism and the metabolomic response to innate immune stimuli. We conducted metabolomic profiling of sera collected from LDLR-/- mice on either normal chow diet (ND) or WD and after a low-dose LPS challenge. WD feeding as well as LPS treatment by themselves elicited pronounced metabolic changes. LPS-induced responses were largely comparable between ND and WD fed groups, yet dynamics differed for several metabolites, including fatty acids and N-acyl amides. In previous studies WD induced epigenetic adaptations and changed responsiveness to innate stimuli in myeloid cells. To investigate whether these are sustained by long-term alterations in systemic metabolism mice fed a WD were shifted back to ND after 4 weeks (WD>ND). When shifted back to ND, serum metabolites identified to be increased upon WD feeding returned to baseline levels. Similarly the metabolic responses to LPS in ND and WD>ND groups resembled each other.