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Metabolite Transporters as Regulators of Immunity

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
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Metabolites 2020, 10(10), 418; https://doi.org/10.3390/metabo10100418
Received: 4 September 2020 / Revised: 14 October 2020 / Accepted: 16 October 2020 / Published: 19 October 2020
In the past decade, the rise of immunometabolism has fundamentally reshaped the face of immunology. As the functions and properties of many (immuno)metabolites have now been well described, their exchange among cells and their environment have only recently sparked the interest of immunologists. While many metabolites bind specific receptors to induce signaling cascades, some are actively exchanged between cells to communicate, or induce metabolic reprograming. In this review, we give an overview about how active metabolite transport impacts immune cell function and shapes immunological responses. We present some examples of how specific transporters feed into metabolic pathways and initiate intracellular signaling events in immune cells. In particular, we focus on the role of metabolite transporters in the activation and effector functions of T cells and macrophages, as prototype adaptive and innate immune cell populations. View Full-Text
Keywords: cell metabolism; immunity; metabolite transporter; solute carrier; T cells; macrophages cell metabolism; immunity; metabolite transporter; solute carrier; T cells; macrophages
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MDPI and ACS Style

Weiss, H.J.; Angiari, S. Metabolite Transporters as Regulators of Immunity. Metabolites 2020, 10, 418. https://doi.org/10.3390/metabo10100418

AMA Style

Weiss HJ, Angiari S. Metabolite Transporters as Regulators of Immunity. Metabolites. 2020; 10(10):418. https://doi.org/10.3390/metabo10100418

Chicago/Turabian Style

Weiss, Hauke J., and Stefano Angiari. 2020. "Metabolite Transporters as Regulators of Immunity" Metabolites 10, no. 10: 418. https://doi.org/10.3390/metabo10100418

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