Special Issue "Metabolic Reprogramming in Innate Immune Cell Fate and Function"

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 1 December 2019

Special Issue Editor

Guest Editor
Dr. Stanley Huang

Department of Pathology, School of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA
Website | E-Mail
Interests: Macrophages; Innate immunity; Immunometabolism; Inflammation; Tumor immunology; Infectious diseases

Special Issue Information

Dear Colleagues,

The field of immunometabolism is an interdisciplinary work between metabolism and immunology research. There is no doubt that immune cell fate and function are intimately linked to metabolic regulations. Meanwhile, inflammation can drive metabolic alterations/disorders to modulate immune cell differentiation and activation.

In this Special Issue, we will focus on how regulatory circuits and nutrients in lipid and mitochondria, carbohydrate and amino acid metabolism, mTOR signaling, autophagy, and endoplasmic reticulum (ER) stress responses shape and fine-tune the differentiation, activation, and effector function of innate immune cells. Additionally, this issue will provide an updated overview on metabolic reprogramming in macrophages, myeloid-derived suppressor cells, dendritic cells, NK/innate lymphoid cells, and B cell humoral immunity in inflammatory microenvironments, such as cancer, infection, atherosclerosis, and obesity.

Molecular and genetic analyses of the immune system have made it clear that immune cells eliminate pathogenic intruders and maintain tissue homeostasis through a complex network of intrinsic and extrinsic signaling and metabolism. Given the complexity of our immune system, systems biology has provided us with informative readouts in changes of single-cell resolution, molecular omics, and chromatin modification. Thus, we will discuss directions and challenges in systems immunometabolism, as single-cell global profiling will continue to define novel states of immune cells associated with healthy and diseased individuals.

Dr. Stanley Huang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • immunometabolism
  • metabolic reprogramming
  • innate immunity
  • immune cell activation
  • inflammatory microenvironment
  • systems immunology

Published Papers

This special issue is now open for submission.
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