Metabolic Reprogramming in Innate Immune Cell Fate and Function
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (1 December 2019) | Viewed by 57868
Special Issue Editor
Interests: innate immunity; macrophages; innate lymphoid cells; immunometabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The field of immunometabolism is an interdisciplinary work between metabolism and immunology research. There is no doubt that immune cell fate and function are intimately linked to metabolic regulations. Meanwhile, inflammation can drive metabolic alterations/disorders to modulate immune cell differentiation and activation.
In this Special Issue, we will focus on how regulatory circuits and nutrients in lipid and mitochondria, carbohydrate and amino acid metabolism, mTOR signaling, autophagy, and endoplasmic reticulum (ER) stress responses shape and fine-tune the differentiation, activation, and effector function of innate immune cells. Additionally, this issue will provide an updated overview on metabolic reprogramming in macrophages, myeloid-derived suppressor cells, dendritic cells, NK/innate lymphoid cells, and B cell humoral immunity in inflammatory microenvironments, such as cancer, infection, atherosclerosis, and obesity.
Molecular and genetic analyses of the immune system have made it clear that immune cells eliminate pathogenic intruders and maintain tissue homeostasis through a complex network of intrinsic and extrinsic signaling and metabolism. Given the complexity of our immune system, systems biology has provided us with informative readouts in changes of single-cell resolution, molecular omics, and chromatin modification. Thus, we will discuss directions and challenges in systems immunometabolism, as single-cell global profiling will continue to define novel states of immune cells associated with healthy and diseased individuals.
Dr. Stanley Huang
Guest Editor
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Keywords
- immunometabolism
- metabolic reprogramming
- innate immunity
- immune cell activation
- inflammatory microenvironment
- systems immunology
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