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The Role of Metabolic Enzymes in the Regulation of Inflammation

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
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Author to whom correspondence should be addressed.
Metabolites 2020, 10(11), 426; https://doi.org/10.3390/metabo10110426
Received: 4 September 2020 / Revised: 19 October 2020 / Accepted: 19 October 2020 / Published: 26 October 2020
Immune cells undergo dramatic metabolic reprogramming in response to external stimuli. These metabolic pathways, long considered as simple housekeeping functions, are increasingly understood to critically regulate the immune response, determining the activation, differentiation, and downstream effector functions of both lymphoid and myeloid cells. Within the complex metabolic networks associated with immune activation, several enzymes play key roles in regulating inflammation and represent potential therapeutic targets in human disease. In some cases, these enzymes control flux through pathways required to meet specific energetic or metabolic demands of the immune response. In other cases, key enzymes control the concentrations of immunoactive metabolites with direct roles in signaling. Finally, and perhaps most interestingly, several metabolic enzymes have evolved moonlighting functions, with roles in the immune response that are entirely independent of their conventional enzyme activities. Here, we review key metabolic enzymes that critically regulate inflammation, highlighting mechanistic insights and opportunities for clinical intervention. View Full-Text
Keywords: immunometabolism; inflammation; metabolism immunometabolism; inflammation; metabolism
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MDPI and ACS Style

Godfrey, W.H.; Kornberg, M.D. The Role of Metabolic Enzymes in the Regulation of Inflammation. Metabolites 2020, 10, 426. https://doi.org/10.3390/metabo10110426

AMA Style

Godfrey WH, Kornberg MD. The Role of Metabolic Enzymes in the Regulation of Inflammation. Metabolites. 2020; 10(11):426. https://doi.org/10.3390/metabo10110426

Chicago/Turabian Style

Godfrey, Wesley H., and Michael D. Kornberg 2020. "The Role of Metabolic Enzymes in the Regulation of Inflammation" Metabolites 10, no. 11: 426. https://doi.org/10.3390/metabo10110426

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