Special Issue "(Epi)genetics and Metabolic Adaptation at Host-Microbe Interface"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (15 October 2018).
Interests: macrophage-microbe interactions; nutritional immunity; metal-ions; gene expression; membrane transport
Interests: immunometabolism; macrophages; innate immunity; inflammation; epigenetics
(Epi)genetics and metabolic adaptation at host-microbe interface: Host–microbe interactions represent an evolutionary arm race that requires metabolic plasticity from the protagonists. For instance, host nutritional immunity is counter-acted by microbial abilities to either persist in a dormant state or steal iron to sustain growth. It was also established that macrophage iron fate strongly varies in “classically” (M1) vs. “alternatively” (M2) activated states. More generally, links between immunometabolism and epigenetic regulation of host cell phenotype were recently emphasized together with the capacity for symbiotic or parasitic micro-organisms to interfere with metabolic programming triggered by immune recognition. Deciphering host–microbe (epi)genetic and metabolic interactions, thus, holds potential for advancing knowledge in the field of infectious and inflammatory diseases.
Dr. Mathieu Cellier
Dr. Jan Van den Bossche
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- Innate immunity
- host-microbe interactions