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College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China
Interests: environmental pollution; toxicology; molecular mechanism; signal pathway; energy metabolism
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Dr. Zhiying Miao

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College of Life Science, Northeast Agricultural University, Harbin 150038, China
Interests: environmental pollution; toxicology; molecular mechanism; intestinal microbiome; oxidative stress

Dr. Zhiruo Miao

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Guest Editor

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150038, China
Interests: pesticides; ecotoxicity; microbial contaminants; mutritional and metabolic diseases; toxipathy

Dr. Dechun Chen

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Guest Editor

College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China
Interests: environmental pollution; microorganism; apoptosis; autophagy; omics analysis

Special Issue Information

Dear Colleagues,

Environmental pollution caused by human activities has brought potential threats to human and animal health, which has attracted worldwide attention. It is one of the most active research fields today. Metabolites not only involve intermediate and final metabolites in metabolism but also participate in the mechanism of animal poisoning caused by environmental pollutants.

This Special Issue focuses on the metabolic mechanism of animal poisoning caused by excess environmental pollutants via soliciting manuscripts (such as original research and review), highlighting toxicity, molecular signaling pathways, and important metabolic targets. We hope that the information generated from this Special Issue will reflect the latest progress in the research on metabolites-related mechanisms in animal poisoning caused by environmental pollution, as well as provide some novel and in-depth findings on metabolomics.

Prof. Dr. Xiaohua Teng
Dr. Zhiying Miao
Dr. Zhiruo Miao
Dr. Dechun Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

environmental pollution
animal
toxicity
molecular mechanism
cell metabolism

Published Papers (2 papers)

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Research

Open AccessArticle

Preliminary Exploration of Metabolic Mechanisms in Copper-Exposed Sepia esculenta Based on Transcriptome Analysis

and

Metabolites 2023, 13(4), 471; https://doi.org/10.3390/metabo13040471 (registering DOI) - 25 Mar 2023

Abstract

As a common and high-concentration heavy metal in the ocean, Cu can induce metal toxicity and significantly affect the metabolic function of marine organisms. Sepia esculenta is an important economic cephalopod found along the east coast of China, the growth, movement, and reproduction of which are all affected by heavy metals. Hitherto, the specific metabolic mechanism of heavy-metal exposure in S. esculenta is still unclear. In this study, we identified 1,131 DEGs through transcriptome analysis of larval S. esculenta within 24 h of Cu exposure. GO and KEGG functional enrichment analysis results indicated that Cu exposure may affect purine metabolism, protein digestion and absorption, cholesterol metabolism, and other metabolic processes in S. esculenta larvae. It is worth noting that in this study we explore metabolic mechanism of Cu-exposed S. esculenta larvae through the comprehensive analysis of protein–protein interaction network and KEGG enrichment analysis for the first time and find 20 identified key and hub genes such as CYP7A1, CYP3A11, and ABCA1. Based on their expression, we preliminarily speculate that Cu exposure may inhibit multiple metabolic processes and induce metabolic disorders. Our results lay a foundation for further understanding the metabolic mechanism of S. esculenta against heavy metals and provide theoretical help for S. esculenta artificial breeding. Full article

(This article belongs to the Special Issue Environmental Pollution and Animal Health: Toxicity and Metabolism)

Open AccessArticle

Exposure to Particulate Matter in the Broiler House Causes Dyslipidemia and Exacerbates It by Damaging Lung Tissue in Broilers

and

Metabolites 2023, 13(3), 363; https://doi.org/10.3390/metabo13030363 - 28 Feb 2023

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Abstract

The high concentration of particulate matter (PM) in broiler houses seriously endangers the biological safety of broilers and causes low growth performance, deserving more attention. This study aimed to investigate the effects of PM collected from a broiler house on the lung and systemic inflammatory responses and liver lipid anabolic process in broilers. Broilers were systemically exposed to fresh air (control) and 4 mg·m⁻³ and 8 mg·m⁻³ total suspended particles (TSP). Lung, liver, and serum were sampled after 7 (E7) and 14 (E14) days of PM exposure and 7 days after self-recovery (R 7). Corresponding kits were used to assay the inflammatory cytokines and serum biochemical indicators. The expression levels of genes related to lipid metabolism were detected by real-time polymerase chain reaction (RT-PCR) assay. The results showed a significant decrease in the average daily gain in broilers for 7 days of PM exposure (p < 0.05) and clear lung and liver inflammations in PM groups. In addition, upregulation of lung interleukin (IL)-1β and IL-8 and serum low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) occurred after 7 days of PM exposure (p < 0.05), and upregulation of lung serum tumor necrosis factor (TNF)-α and cholesterol (CHOL) occurred after 14 days of PM exposure (p < 0.05). A decrease in serum total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-px) levels was found after 14 days of PM exposure (p < 0.05), and the GSH-px level was maintained until 7 days after cessation of exposure (p < 0.05). Seven days after cessation of exposure, the expression levels of 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2) and fatty acid synthase (Fas) genes significantly increased (p < 0.05) and decreased (p < 0.05), respectively. These results demonstrate that exposure to PM in broiler houses can induce systemic inflammation and dyslipidemia through local pulmonary inflammation and also exert toxic effects on the liver by disturbing the expression of genes involved in the hepatic lipid anabolic process. Full article

(This article belongs to the Special Issue Environmental Pollution and Animal Health: Toxicity and Metabolism)

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