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Medicina
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Diagnosis, Evaluation, and Management of Diseases During Pregnancy: Third Edition
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Diagnosis, Evaluation, and Management of Diseases During Pregnancy: Third Edition

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Obstetrics and Gynecology".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 1287

Special Issue Editors

Prof. Dr. Marius L. Craina

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Victor Babes", 300001 Timisoara, Romania
Interests: gynecology; obstetrics, gynecological oncology; endocrinology and reproductive medicine; ethics; medical education; research design; epidemiology and statistics
Special Issues, Collections and Topics in MDPI journals
Dr. Elena Bernad

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy “Victor Babes”, 300001 Timisoara, Romania
Interests: gynecology; obstetrics; gynecological oncology; endocrinology and reproductive medicine; ethics; medical education; research design; epidemiology and statistics; computer applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

How an individual’s associated comorbidities can affect their pregnancy has always been an essential concern for medical specialists. The presence of these health conditions, no matter how minor, requires additional evaluation and appropriate treatment to avoid complications. They can worsen throughout the gestation period, influencing maternal health status, the evolution of pregnancy, and the outcome of birth. Thus, a perinatologist evaluates the pathology in collaboration with a specialist to reach the most favorable outcome for the patient and the fetus.

Despite success in understanding the pathophysiology and treatment development of multiple pathological conditions over the last few decades, many questions remain unsolved. Therefore, the purpose of this Special Issue is to share current management strategies regarding maternal-associated pathology from personal acquired experience and guidelines worldwide. This Special Issue will allow specialists worldwide to access public results of state-of-the-art research in prenatal care in cases with comorbidities. Moreover, this Special Issue aims to collect papers that reflect further progress in this field in the form of original research manuscripts, reviews, and case reports.

This Special Issue is the continuation of the Special Issue "Diagnosis, Evaluation, and Management of Diseases during Pregnancy: Part II".

Prof. Dr. Marius L. Craina
Dr. Elena Bernad
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pregnancy
  • fetus prenatal care
  • high risk
  • pathology
  • genetics
  • endocrine system diseases
  • nutrition disorders
  • cardiovascular diseases
  • female urogenital diseases
  • immune system diseases
  • infections
  • neoplasms

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Related Special Issue

Published Papers (2 papers)

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Research

15 pages, 1159 KiB  
Article
Maternal and Fetal–Neonatal Complications of Romanian Women with Gestational Diabetes: A Retrospective Comparative Study
by Adriana Gherbon, Mirela Frandes, Corina Dalia Toderescu, Darius Dirpes, Romulus Timar, Marioara Neagu Nicula, Calin Dascau, Razvan Daniluc and Bogdan Timar
Medicina 2025, 61(7), 1190; https://doi.org/10.3390/medicina61071190 - 30 Jun 2025
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Abstract
Background and Objectives: Gestational diabetes mellitus (GDM) is a complex condition characterized by metabolic disorders of blood glucose that significantly impact the health of both mother and fetus. The objectives of this study were to assess the prevalence and risk factors for maternal [...] Read more.
Background and Objectives: Gestational diabetes mellitus (GDM) is a complex condition characterized by metabolic disorders of blood glucose that significantly impact the health of both mother and fetus. The objectives of this study were to assess the prevalence and risk factors for maternal and fetal–neonatal complications in women with GDM, comparing them to a control group (pregnant women without GDM) and pregnant women with type 1 diabetes mellitus (T1DM) or type 2 diabetes (T2DM). Materials and Methods: A retrospective observational study was conducted with 1418 pregnant women (279 with GDM, 74 with T1DM, 107 with T2DM, and 958 in the control group). The retrospective data included information on demographics, diagnostic test results, the medical history of pregnant women, treatments administered, identified complications, and other relevant variables for the study’s purpose. Results: Significant differences were found regarding maternal and neo-fetal complications between GDM and the control group in terms of abortion, pregnancy-induced hypertension, and increased fetal weight (macrosomia). Women with T1DM and T2DM showed a higher rate of abortion, premature birth, and an APGAR score of <7 at 5 min compared to those with GDM, and for T1DM, there was a higher rate of fetal mortality than in GDM cases. The primary risk factors for maternal complications included age OR = 1.03 (95% CI: 1.01–1.05, p = 0.002), obesity OR = 2.37 (95% CI: 1.42–3.94, p < 0.001), and chronic hypertension OR = 2.51 (95% CI: 1.26–5.01, p = 0.009). Age and obesity were also significant cofactors for maternal complications. Furthermore, the main significant risk factors for fetal–neonatal complications were obesity OR = 2.481 (95% CI:1.49–4.12, p < 0.001) and chronic hypertension OR = 2.813 (95% CI:1.44–5.49, p = 0.002), both independently and as cofactors. Conclusions: We found that obesity and chronic hypertension are risk factors for both maternal and fetal–neonatal complications. It is essential to prevent and adequately treat these two factors among pregnant women to avoid the onset of GDM. Additionally, screening for GDM is necessary to prevent maternal and fetal complications. Our results highlight the importance of specialized medical care and tailored management protocols in mitigating risks and ensuring positive outcomes for both mother and child during and after childbirth. Full article
(This article belongs to the Special Issue Diagnosis, Evaluation, and Management of Diseases During Pregnancy: Third Edition)
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12 pages, 301 KiB  
Article
Circulating Potassium/Magnesium Ratio, Thyroid Stimulating Hormone, Fasting Plasma Glucose, Oxidized LDL/Albumin Ratio, and Urinary Iodine Concentration Are Possible Entities for Screening for Preeclampsia in Low-Resource Settings
by Charles Bitamazire Businge, Benjamin Longo-Mbenza and Andre Pascal Kengne
Medicina 2025, 61(4), 600; https://doi.org/10.3390/medicina61040600 - 26 Mar 2025
Viewed by 551
Abstract
Background and Objectives: Several micro- and macro-nutrient malnutrition states that are routinely assessed during clinical care of women in the antenatal period have been proposed as risk factors for preeclampsia. However, there is a paucity of data on the potential use of [...] Read more.
Background and Objectives: Several micro- and macro-nutrient malnutrition states that are routinely assessed during clinical care of women in the antenatal period have been proposed as risk factors for preeclampsia. However, there is a paucity of data on the potential use of these biomarkers for detection of preeclampsia. The aim of this case-control study was to investigate the association of biomarkers from routine clinical tests, and those specific to micro- and macro-nutrient malnutrition, with the risk of preeclampsia. Materials and Methods: Venous blood samples of 250 participants with preeclampsia and 150 pregnant women without preeclampsia were collected and assayed immediately for the full blood count, urea and electrolytes, high-density cholesterol (HDL), total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), oxidized low-density lipoprotein cholesterol (OxLDL), and selenium, in addition to urine iodine concentration (UIC). Results: The serum potassium/magnesium ratio (K+/Mg2+), UIC, fasting plasma glucose (FPG), thyroid stimulating hormone (TSH), lymphocyte percentage (L/WBC%), and the oxidized LDL/albumin ratio (OxLDL/Alb) were identified as independent predictors of preeclampsia. Conclusions: Serum potassium/magnesium ratio and other analytes essential for various biological processes, some of which are assayed during routine care, were significantly associated with preeclampsia, warranting further exploration as potential screening biomarkers in low-resource settings. Full article
(This article belongs to the Special Issue Diagnosis, Evaluation, and Management of Diseases During Pregnancy: Third Edition)
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