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Medicina
Special Issues
Burn Injuries and Burn Rehabilitation
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Burn Injuries and Burn Rehabilitation

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Surgery".

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 5817

Special Issue Editor

Dr. Cheong Hoon Seo

E-Mail Website
Guest Editor
Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 07247, Republic of Korea
Interests: wound healing; hypertrophic scar; skin rehabilitation; burn pain
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Burn injuries, classified into varying degrees of severity, can result from a multitude of sources, such as thermal, chemical, electrical, or even radiation exposure. These injuries not only inflict physical harm but can also have profound psychological and social repercussions.

Effective burn rehabilitation is essential to address the multifaceted nature of these injuries. It involves a dedicated team of healthcare professionals, including burn surgeons, therapists, and psychologists, working together through different phases of rehabilitation. The goal is to help survivors regain physical function, manage emotional trauma, and successfully reintegrate into society. Advances in burn care, such as innovative skin graft alternatives and telemedicine, continue to enhance the prospects for burn survivors, but the challenges, including high healthcare costs and the enduring impact of burns, persist.

Therefore, this Special Issue aims to update the information on burn injuries and burn rehabilitation and provide new insights into innovative approaches for burn injuries and burn rehabilitation. This Special Issue welcomes all submissions related to the diagnosis and treatment of burn injuries and burn rehabilitation, including original research articles, reviews, and opinion papers.

Dr. Cheong Hoon Seo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound healing
  • burn injuries
  • inflammation
  • burn rehabilitation
  • burn care
  • skin graft alternatives
  • plastic surgery in burns

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Published Papers (3 papers)

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Research

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15 pages, 6049 KiB  
Article
Slit1 Promotes Hypertrophic Scar Formation Through the TGF-β Signaling Pathway
by Hui Song Cui, Ya Xin Zheng, Yoon Soo Cho, Yu Mi Ro, Kibum Jeon, So Young Joo and Cheong Hoon Seo
Medicina 2024, 60(12), 2051; https://doi.org/10.3390/medicina60122051 - 12 Dec 2024
Viewed by 1608
Abstract
Background and objectives: Slit1 is a secreted protein that is closely related to cell movement and adhesion. Few studies related to fibrosis exist, and the preponderance of current research is confined to the proliferation and differentiation of neural systems. Hypertrophic scars (HTSs) are [...] Read more.
Background and objectives: Slit1 is a secreted protein that is closely related to cell movement and adhesion. Few studies related to fibrosis exist, and the preponderance of current research is confined to the proliferation and differentiation of neural systems. Hypertrophic scars (HTSs) are delineated by an overproduction of the extracellular matrix (ECM) by activated fibroblasts, leading to anomalous fibrosis, which is a severe sequela of burns. However, the functionality of Slit1 in HTS formation remains unknown. We aimed to investigate whether Slit1 regulates fibroblasts through a fibrosis-related mechanism derived from post-burn HTS tissues and normal patient tissues. Methods: Human normal fibroblasts (HNFs) and hypertrophic scar fibroblasts (HTSFs) were extracted from normal skin and post-burn HTS tissues, with settings grouped according to the patient of origin. Cell proliferation was evaluated using a CellTiter-Glo Luminescent Cell Viability Assay Kit. Cell migration experiments were carried out using a μ-Dish insert system. Protein and mRNA expression levels were quantified by Western blot and quantitative real-time polymerase chain reaction. Results: We found increased expressions of Slit1 in HTS tissues and HTSFs compared to normal tissues and HNFs. The treatment of human recombinant Slit1 protein (rSlit1) within HNFs promoted cell proliferation and differentiation, leading to an upregulation in ECM components such as α-SMA, type I and III collagen, and fibronectin. The treatment of rSlit1 in HNFs facilitated cell migration, concurrent with enhanced levels of N-cadherin and vimentin, and a diminished expression of E-cadherin. Treatment with rSlit1 resulted in the phosphorylation of SMAD pathway proteins, including SMAD2, SMAD3, and SMAD1/5/8, and non-SMAD pathway proteins, including TAK1, JNK1, ERK1/2, and p38, in HNFs. Conclusions: Exogenous Slit1 potentiates the epithelial–mesenchymal transition and upregulates SMAD and non-SMAD signaling pathways in HNFs, leading to the development of HTS, suggesting that Slit1 is a promising new target for the treatment of post-burn HTS. Full article
(This article belongs to the Special Issue Burn Injuries and Burn Rehabilitation)
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Other

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12 pages, 8353 KiB  
Case Report
The Successful Treatment of a Patient with Ehlers–Danlos Syndrome (EDS) After an Extensive Burn Injury: A Case Report
by Karolina Ziółkowska, Anna Słaboń, Justyna Glik, Mariusz Maj, Magdalena Olszak, Karolina Mikuś-Zagórska, Przemysław Strzelec, Katarzyna Czerny, Ryszard Maciejowski, Marcin Gierek and Wojciech Łabuś
Medicina 2025, 61(4), 554; https://doi.org/10.3390/medicina61040554 - 21 Mar 2025
Cited by 1 | Viewed by 1144
Abstract
Introduction: Ehlers–Danlos Syndromes (EDSs) are a heterogeneous group of monogenic connective tissue disorders (e.g., joint hypermobility and dislocation, skin hyperelasticity and fragility, chronic pain, delayed wound healing process,, etc.). The primary objective of this study was to present a specialized therapeutic wound [...] Read more.
Introduction: Ehlers–Danlos Syndromes (EDSs) are a heterogeneous group of monogenic connective tissue disorders (e.g., joint hypermobility and dislocation, skin hyperelasticity and fragility, chronic pain, delayed wound healing process,, etc.). The primary objective of this study was to present a specialized therapeutic wound management process for a burn-injured female patient diagnosed with EDS. Case Presentation: A 34-year-old female patient presented with extensive thermal burns (biofireplace explosion). The patient had a family history of diagnosed EDS. Additionally, the patient was in a poor mental condition and, since 2020, had been undergoing pharmacotherapy with antidepressant and anti-anxiety medication. This might be the first such clinical observation in the world, but a correlation has been observed between psychiatric medication use and EDS wound healing impairment. During the hospitalization process, the patient underwent a series of surgeries aimed at the fastest and most effective closure of wounds. The patient, after 182 days of hospitalization in our facility, was discharged home. Materials and Methods: During the patient’s hospital stay, the patient underwent multiple procedures involving debridement of necrotic tissues. Additionally, allogeneic acellular dermal matrix (ADM) grafting was performed on the wounds, and a procedure was conducted in which skin was grafted using the MEEK technique. The in vitro cultured skin cells, as the advanced therapy medicinal products (ATMPs), were used. During the patient’s stay in the hospital, images were taken using low-energy laser speckle contrast analysis (LASCA) to asses microperfusion or lack thereof. The measurements were taken at intervals of several days. Conclusions: The treatment of burn wounds in patients with EDS requires a long hospitalization period. It also may require a multi-stage approach utilizing innovative preparations (e.g., ADMs and ATMPs). The assessment of wound healing progress can be performed using advanced equipment, such as laser speckle contrast analysis (LASCA). Full article
(This article belongs to the Special Issue Burn Injuries and Burn Rehabilitation)
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10 pages, 1470 KiB  
Case Report
Multidisciplinary Management and Autologous Skin Grafting in a Patient with Severe Burns: A Case Study
by Giovanni Cangelosi, Stefano Mancin, Diego Bei, Eleonora Clementi, Paola Pantanetti, Gabriele Caggianelli and Fabio Petrelli
Medicina 2024, 60(8), 1201; https://doi.org/10.3390/medicina60081201 - 24 Jul 2024
Cited by 1 | Viewed by 2410
Abstract
Background: Heat burns are a prevalent type of trauma. Rapid and effective treatment is crucial for deep burns to minimize complications. Autologous skin grafting is a highly effective treatment for full-thickness burns. A multidisciplinary team plays a vital role in managing burn [...] Read more.
Background: Heat burns are a prevalent type of trauma. Rapid and effective treatment is crucial for deep burns to minimize complications. Autologous skin grafting is a highly effective treatment for full-thickness burns. A multidisciplinary team plays a vital role in managing burn patients undergoing skin grafting, from initial contact to outpatient follow-up. Case Summary: This case study involves a 56-year-old patient who suffered burns on 60% of his body following an alcohol explosion on an open flame. The patient underwent autologous skin grafting at a Major Burn Center. Initial symptoms included severe pain and immobility, but the patient remained alert and breathed spontaneously. The diagnosis was a loss of epidermis and dermis with burns covering 60–69% of the total body surface area (TBSA) and third-degree burns covering 10% TBSA. Post-discharge, the patient showed significant improvement, with complete healing of the grafts and partial resolution of other lesions. Six months after the intervention, the patient significantly improved his autonomy and mobility. Conclusions: This case highlights the importance of burn prevention and the critical role of multidisciplinary teams in the entire care pathway of burn patients. Appropriate diagnosis, complete treatment, and continuous multidisciplinary support are essential to prevent complications and ensure recovery. Full article
(This article belongs to the Special Issue Burn Injuries and Burn Rehabilitation)
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