Special Issue "Multifunctional Materials in Tissue Regeneration"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 30 December 2019.

Special Issue Editors

Prof. Dr. Lia Rimondini
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Guest Editor
Department of Health Sciences, University of Piemonte Orientale “UPO”, Italy
Interests: biomaterials; dental materials; tissue regeneration; tissue engineering; oral medicine; bacterial biofilm; anti-iinfective technologies
Special Issues and Collections in MDPI journals
Dr. Andrea Cochis
E-Mail
Guest Editor
Department of Health Sciences, Università del Piemonte Orientale, Alessandria-Novara- Vervelli, Italy
Interests: oral implants; biomaterials; tissue regeneration
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Tissue regeneration is an attractive approach to restore and replace diseased or defective tissues for organs rehabilitation. It involves the use of proper scaffolds mimicking the extracellular matrix and able to support pivotal regenerative steps such cells signalling, recruitment, adhesion, proliferation and specific function. Accordingly, Scaffolds, signalling and cells are the magic Triad for regeneration.

In this scenario, Biomaterials take the challenge to reconstruct a suitable environment for cells function and, at the same time, to provide a mechanically robust three-dimensional structures protecting the healing process when clinically applied.

They should differently orchestrate the biological response in order i) to foster the growth of different types of tissues, and ii) to avoid infections during and after healing.

In addition, they should offer the possibility to monitoring the heling process and properly modify their properties in relation to the clinical needs.

The scope of this Special Issue, entitled “The Multifunctional Materials in Tissue Regeneration” is to provide the state-of-the-art of the research on the properties, the production, the characterization and the applications of biomaterials with contextual different properties addressed to optimize and monitor tissues regeneration.

This Special Issue aims at collecting experimental or theoretical review articles and leading-edge research papers dealing with biomaterials, stem cells biology, microbiology, in-vitro modeling for regenerative medicine applications

Prof. Dr. Lia Rimondini
Dr. Andrea Cochis
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Multifunctional materials
  • biomaterials
  • scaffolds
  • implants
  • regenerative medicine
  • anti-infective materials
  • stem cells
  • organoids
  • organ-on-chip

Published Papers (2 papers)

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Research

Open AccessArticle
Cell-Free Demineralized Bone Matrix for Mesenchymal Stem Cells Survival and Colonization
Materials 2019, 12(9), 1360; https://doi.org/10.3390/ma12091360 - 26 Apr 2019
Abstract
Decellularized bone matrix is receiving much attention as biological scaffolds and implantable biomaterials for bone tissue regeneration. Here, we evaluated the efficacy of a cell-free demineralized bone matrix on mesenchymal stem cells (MSCs) survival and differentiation in vitro. The seeding of human umbilical [...] Read more.
Decellularized bone matrix is receiving much attention as biological scaffolds and implantable biomaterials for bone tissue regeneration. Here, we evaluated the efficacy of a cell-free demineralized bone matrix on mesenchymal stem cells (MSCs) survival and differentiation in vitro. The seeding of human umbilical cord-derived MSCs (hUC-SCs) on decellularized bone matrices up to 14 days was exploited, assessing their capability of scaffold colonization and evaluating gene expression of bone markers. Light and Scanning Electron Microscopies were used. The obtained cell-free decalcified structures showed elastic moduli attributable to both topology and biochemical composition. Morphological observation evidenced an almost complete colonization of the scaffolds after 14 days of culture. Moreover, in hUC-SCs cultured on decalcified scaffolds, without the addition of any osteoinductive media, there was an upregulation of Collagen Type I (COL1) and osteonectin (ON) gene expression, especially on day 14. Modifications in the expression of genes engaged in stemness were also detected. In conclusion, the proposed decellularized bone matrix can induce the in vitro hUC-SCs differentiation and has the potential to be tested for in in vivo tissue regeneration. Full article
(This article belongs to the Special Issue Multifunctional Materials in Tissue Regeneration)
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Open AccessArticle
Influence of Porous Dressings Based on Butyric-Acetic Chitin Co-Polymer on Biological Processes In Vitro and In Vivo
Materials 2019, 12(6), 970; https://doi.org/10.3390/ma12060970 - 23 Mar 2019
Abstract
In spite of intensively conducted research allowing for the development of more and more advanced wound dressing materials, there is still a need for dressings that stimulate not only reparative and regenerative processes, but also have a positive effect on infected and/or difficult-to-heal [...] Read more.
In spite of intensively conducted research allowing for the development of more and more advanced wound dressing materials, there is still a need for dressings that stimulate not only reparative and regenerative processes, but also have a positive effect on infected and/or difficult-to-heal wounds. Porous dressing materials based on butyric-acetic chitin co-polyester containing 90% of butyryl and 10% of acetyl groups (BAC 90/10) can also be included in the group mentioned above. Two types of dressings were obtained by the salt leaching method, i.e. a porous sponge Medisorb R and Medisorb Ag with an antibacterial additive. The aim of the study was to evaluate biological effects of porous Medisorb R and Medisorb Ag dressings under in vitro and in vivo conditions. In an in vitro biodegradation test, no mass loss of Medisorb R dressing was observed within 14 days of incubation in physiological fluids at 37 °C. However, on the basis of the FTIR (Fourier Transform Infrared Spectroscopy) tests, surface degradation of Medisorb R dressing was observed. Additionally, the antibacterial activity of the porous Medisorb Ag dressing containing microsilver as an antibacterial additive was confirmed. The in vivo studies included inflammatory activity, skin irritation and sensitisation tests, as well an assessment of local effect after contact with subcutaneous tissue up to 6 months and skin wounds up to 21 days. In the in vivo tests, the dressings exhibited neither effects of skin irritation nor sensitisation. Under macroscopic examination, in full thickness defects of subcutaneous tissue and skin, the dressings caused wound healing with no inflammation, undergoing the most gradual biodegradation between weeks 4 and 8, and the observed differences were statistically significant. In the histological assessment, a weakened, limited inflammatory process associated with degradation of the material has been observed. The process of skin wound healing under Medisorb R dressing in the early period was accelerated compared to that observed in the control group with a gauze dressing. Full article
(This article belongs to the Special Issue Multifunctional Materials in Tissue Regeneration)
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