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Marine Drugs
Special Issues
Bioactive Compounds from Marine Angiosperms
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Bioactive Compounds from Marine Angiosperms

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 21094

Special Issue Editor

Dr. Giuseppina Chianese

E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano, 49, I-80131 Naples, Italy
Interests: natural product chemistry; chromatography; phytochemicals; natural product isolation; extraction; natural product drug discovery; compound isolation; NMR structure elucidation; mass spectrometry; metabolomics

Special Issue Information

Dear Colleagues,

Angiosperms are an important part of the marine ecosystem, including underwater flowering plants and also emergent and subemergent macrophytes that live in marine environments. They are an outstanding reservoir of structurally diverse bioactive compounds with potential use as food additives, nutraceuticals, and drugs. This issue of Marine Drugs entitled “Bioactive Compounds from Marine Angiosperms” aims to highlight different aspects of bioactive compounds found in aquatic plants living in sea environments, such as seagrasses and mangroves, including compounds produced from their associated microorganisms. Specifically, we are interested in new research identifying the chemical structure, bioactivity evaluation, and source and biosynthetic pathways of bioactive compounds. Additionally, considering recent advances in the application of the coupling of chromatographic and spectroscopic techniques for the analysis of extracts, as Guest Editor, I encourage the submission of research papers describing the phytochemical analysis based on chemical dereplication, finger-printing, metabolomic studies, and molecular networking. Comprehensive review papers that synthesize current knowledge on bioactive compounds and their applications from marine angiosperms are also welcome.

Dr. Giuseppina Chianese
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Angiosperms
  • Seagrasses
  • Mangroves
  • Marine natural products
  • Bioactive molecules
  • Secondary metabolites
  • NMR
  • Extraction
  • Structure elucidation
  • Metabolomics
  • LC/MS
  • Biological activity

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Published Papers (5 papers)

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Research

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9 pages, 1494 KiB  
Article
Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y45 That Inhibit Nitric Oxide Production
by Xiaoya Qin, Jiguo Huang, Dexiong Zhou, Wenxiu Zhang, Yanjun Zhang, Jun Li, Ruiyun Yang and Xishan Huang
Mar. Drugs 2022, 20(1), 5; https://doi.org/10.3390/md20010005 - 21 Dec 2021
Cited by 16 | Viewed by 3131
Abstract
Four undescribed compounds, guhypoxylonols A (1), B (2), C (3), and D (4), were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of 1–4 [...] Read more.
Four undescribed compounds, guhypoxylonols A (1), B (2), C (3), and D (4), were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of 1–4 were elucidated based on analysis of HRESIMS and NMR spectroscopic data. The absolute configurations of the stereogenic carbons in 1–3 were established through a combination of spectroscopic data and electronic circular dichroism (ECD). Compounds 1–11 were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4, and 6 showed an inhibitory activity against the production of nitric oxide (NO), with the IC50 values of 14.42 ± 0.11, 18.03 ± 0.14, 16.66 ± 0.21, and 21.05 ± 0.13 μM, respectively. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Angiosperms)
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10 pages, 1080 KiB  
Article
New Cytotoxic Cytochalasans from a Plant-Associated Fungus Chaetomium globosum kz-19
by Tantan Li, Yun Wang, Li Li, Mengyue Tang, Qinghong Meng, Cun Zhang, Erbing Hua, Yuehu Pei and Yi Sun
Mar. Drugs 2021, 19(8), 438; https://doi.org/10.3390/md19080438 - 31 Jul 2021
Cited by 11 | Viewed by 2267
Abstract
Four new cytochalasans, phychaetoglobins A–D (1–4), together with twelve known cytochalasans (5–16), were isolated from a mangrove-associated fungus Chaetomium globosum kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, [...] Read more.
Four new cytochalasans, phychaetoglobins A–D (1–4), together with twelve known cytochalasans (5–16), were isolated from a mangrove-associated fungus Chaetomium globosum kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculations. The absolute configuration of 2 was established by application of Mosher’s method. Compounds 4–8 exhibited moderate cytotoxicities against A549 and HeLa cell lines with the IC50 values less than 20 μM. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Angiosperms)
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18 pages, 1691 KiB  
Article
Molecular Networking Leveraging the Secondary Metabolomes Space of Halophila stipulaceae (Forsk.) Aschers. and Thalassia hemprichii (Ehrenb. ex Solms) Asch. in Tandem with Their Chemosystematics and Antidiabetic Potentials
by Nesrine M. Hegazi, Hamada H. Saad, Mona M. Marzouk, Mohamed F. Abdel Rahman, Mahitab H. El Bishbishy, Ahmed Zayed, Roland Ulber and Shahira M. Ezzat
Mar. Drugs 2021, 19(5), 279; https://doi.org/10.3390/md19050279 - 18 May 2021
Cited by 18 | Viewed by 3944
Abstract
The Red Sea is one of the most biodiverse aquatic ecosystems. Notably, seagrasses possess a crucial ecological significance. Among them are the two taxa Halophila stipulacea (Forsk.) Aschers., and Thalassia hemprichii (Ehrenb. ex Solms) Asch., which were formally ranked together with the genus [...] Read more.
The Red Sea is one of the most biodiverse aquatic ecosystems. Notably, seagrasses possess a crucial ecological significance. Among them are the two taxa Halophila stipulacea (Forsk.) Aschers., and Thalassia hemprichii (Ehrenb. ex Solms) Asch., which were formally ranked together with the genus Enhalus in three separate families. Nevertheless, they have been recently classified as three subfamilies within Hydrocharitaceae. The interest of this study is to explore their metabolic profiles through ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS/MS) analysis in synergism with molecular networking and to assess their chemosystematics relationship. A total of 144 metabolites were annotated, encompassing phenolic acids, flavonoids, terpenoids, and lipids. Furthermore, three new phenolic acids; methoxy benzoic acid-O-sulphate (16), O-caffeoyl-O-hydroxyl dimethoxy benzoyl tartaric acid (26), dimethoxy benzoic acid-O-sulphate (30), a new flavanone glycoside; hexahydroxy-monomethoxy flavanone-O-glucoside (28), and a new steviol glycoside; rebaudioside-O-acetate (96) were tentatively described. Additionally, the evaluation of the antidiabetic potential of both taxa displayed an inherited higher activity of H. stipulaceae in alleviating the oxidative stress and dyslipidemia associated with diabetes. Hence, the current research significantly suggested Halophila, Thalassia, and Enhalus categorization in three different taxonomic ranks based on their intergeneric and interspecific relationship among them and supported the consideration of seagrasses in natural antidiabetic studies. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Angiosperms)
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Review

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37 pages, 1948 KiB  
Review
A Comprehensive Update on the Bioactive Compounds from Seagrasses
by Christina Mutiara Putri Gono, Peni Ahmadi, Triana Hertiani, Eris Septiana, Masteria Yunovilsa Putra and Giuseppina Chianese
Mar. Drugs 2022, 20(7), 406; https://doi.org/10.3390/md20070406 - 21 Jun 2022
Cited by 22 | Viewed by 4114
Abstract
Marine angiosperms produce a wide variety of secondary metabolites with unique structural features that have the potential to be developed as effective and potent drugs for various diseases. Recently, research trends in secondary metabolites have led to drug discovery with an emphasis on [...] Read more.
Marine angiosperms produce a wide variety of secondary metabolites with unique structural features that have the potential to be developed as effective and potent drugs for various diseases. Recently, research trends in secondary metabolites have led to drug discovery with an emphasis on their pharmacological activity. Among marine angiosperms, seagrasses have been utilized for a variety of remedial purposes, such as treating fevers, mental disorders, wounds, skin diseases, muscle pain, and stomach problems. Hence, it is essential to study their bioactive metabolites, medical properties, and underlying mechanisms when considering their pharmacological activity. However, there is a scarcity of studies on the compilation of existing work on their pharmacological uses, pharmacological pathways, and bioactive compounds. This review aims to compile the pharmacological activities of numerous seagrass species, their secondary metabolites, pharmacological properties, and mechanism of action. In conclusion, this review highlights the potency of seagrasses as a promising source of natural therapeutical products for preventing or inhibiting human diseases. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Angiosperms)
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15 pages, 21392 KiB  
Review
An Overview of New Insights into the Benefits of the Seagrass Posidonia oceanica for Human Health
by Marzia Vasarri, Anna Maria De Biasi, Emanuela Barletta, Carlo Pretti and Donatella Degl’Innocenti
Mar. Drugs 2021, 19(9), 476; https://doi.org/10.3390/md19090476 - 25 Aug 2021
Cited by 20 | Viewed by 6366
Abstract
Posidonia oceanica (L.) Delile is a Mediterranean-endemic angiosperm often described for its great ecological importance. Despite evidence of a millennia-old relationship between P. oceanica and humans, as well as traditional medicine applications, the potential benefits of P. oceanica for human health have been [...] Read more.
Posidonia oceanica (L.) Delile is a Mediterranean-endemic angiosperm often described for its great ecological importance. Despite evidence of a millennia-old relationship between P. oceanica and humans, as well as traditional medicine applications, the potential benefits of P. oceanica for human health have been documented only recently. This review aims to compile newly acquired knowledge on P. oceanica bioactive properties that allow the scientific community to look at this plant as a promising source of natural therapeutical products for human health. Experimental investigations conducted in both in vitro cellular-based and in vivo animal models pave the way for new research projects aiming at the development of alternative and complementary therapeutic strategies based on P. oceanica against a wide range of pathological conditions. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Angiosperms)
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