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Open AccessArticle

New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54

1
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
2
Liuzhou Railway Secondary Middle School, Heping Road, Liuzhou 545007, Guang Xi, China
3
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University Duesseldorf, 40225 Duesseldorf, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2018, 16(4), 108; https://doi.org/10.3390/md16040108
Received: 9 February 2018 / Revised: 16 March 2018 / Accepted: 19 March 2018 / Published: 28 March 2018
(This article belongs to the Special Issue Bioactive Compounds from Mangroves and Their-Associated Microbes)
Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (14), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells. View Full-Text
Keywords: endophytic fungus; Penicillium sp.; sesquiterpenoids; cytotoxicity endophytic fungus; Penicillium sp.; sesquiterpenoids; cytotoxicity
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Qiu, L.; Wang, P.; Liao, G.; Zeng, Y.; Cai, C.; Kong, F.; Guo, Z.; Proksch, P.; Dai, H.; Mei, W. New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54. Mar. Drugs 2018, 16, 108.

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