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New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Liuzhou Railway Secondary Middle School, Heping Road, Liuzhou 545007, Guang Xi, China
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University Duesseldorf, 40225 Duesseldorf, Germany
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2018, 16(4), 108;
Received: 9 February 2018 / Revised: 16 March 2018 / Accepted: 19 March 2018 / Published: 28 March 2018
(This article belongs to the Special Issue Bioactive Compounds from Mangroves and Their-Associated Microbes)
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Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (14), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells. View Full-Text
Keywords: endophytic fungus; Penicillium sp.; sesquiterpenoids; cytotoxicity endophytic fungus; Penicillium sp.; sesquiterpenoids; cytotoxicity

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Qiu, L.; Wang, P.; Liao, G.; Zeng, Y.; Cai, C.; Kong, F.; Guo, Z.; Proksch, P.; Dai, H.; Mei, W. New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54. Mar. Drugs 2018, 16, 108.

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