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Open AccessArticle

Two New Cytotoxic Compounds from a Deep-Sea Penicillum citreonigrum XT20-134

Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China
Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315832, China
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(9), 509;
Received: 28 July 2019 / Revised: 25 August 2019 / Accepted: 27 August 2019 / Published: 29 August 2019
(This article belongs to the Special Issue Deep-Sea Natural Products II)
Penicillum citreonigrum XT20-134 (MCCC 3A00956) is a fungus with cytotoxic activity, derived from deep-sea sediment. Five new compounds, adeninylpyrenocine (1), 2-hydroxyl-3-pyrenocine-thio propanoic acid (2), ozazino-cyclo-(2,3-dihydroxyl-trp-tyr) (3), 5,5-dichloro-1-(3,5-dimethoxyphenyl)-1,4-dihydroxypentan-2-one (4), and 2,3,4-trihydroxybutyl cinnamate (5), together with 19 known compounds (624), were isolated from an ethyl acetate (EtOAc) extract of its fermentation. The structures of the new compounds were comprehensively characterized by high-resolution electrospray ionization-mass spectrometry (HR-ESI-MS), 1D and 2D nuclear magnetic resonance (NMR). All isolates were evaluated for their cytotoxic activities. The heteroatom-containing new compounds 2 and 4 showed potent cytotoxicity to the human hepatoma tumor cell Bel7402 with IC50 values of 7.63 ± 1.46, 13.14 ± 1.41 μM and the human fibrosarcoma tumor cell HT1080 with IC50 values of 10.22 ± 1.32, 16.53 ± 1.67 μM, respectively. View Full-Text
Keywords: Penicillum citreonigrum XT20-134; MCCC 3A00956; deep-sea fungus; cytotoxic activity Penicillum citreonigrum XT20-134; MCCC 3A00956; deep-sea fungus; cytotoxic activity
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Tang, X.-X.; Liu, S.-Z.; Yan, X.; Tang, B.-W.; Fang, M.-J.; Wang, X.-M.; Wu, Z.; Qiu, Y.-K. Two New Cytotoxic Compounds from a Deep-Sea Penicillum citreonigrum XT20-134. Mar. Drugs 2019, 17, 509.

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