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Open AccessArticle

Penigrisacids A–D, Four New Sesquiterpenes from the Deep-Sea-Derived Penicillium griseofulvum

1
Key Laboratory of Marine Biogenetic Resources, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China
2
College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 361021, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(9), 507; https://doi.org/10.3390/md17090507
Received: 6 August 2019 / Revised: 27 August 2019 / Accepted: 27 August 2019 / Published: 29 August 2019
(This article belongs to the Special Issue Deep-Sea Natural Products II)
Four new (penigrisacids A–D, 14) and one known (5) carotane sesquiterpenoids were isolated from the deep-sea-derived fungus Penicillium griseofulvum, along with four known compounds (69). The planar structures and relative configurations of the new compounds were determined by extensive analysis of the NMR and HRESIMS data. The absolute configurations were established by comparison of the experimental and calculated ECD (electronic circular dichroism) spectra or OR (optical rotation) value. Compound 9 exhibited potent anti-food allergic activity with IC50 value of 28.7 μM, while 4 showed weak cytotoxicity against ECA-109 tumor cells (IC50 = 28.7 μM). View Full-Text
Keywords: deep-sea-derived fungus; Penicillium griseofulvum; carotanes; sesquiterpenes; anti-food allergy deep-sea-derived fungus; Penicillium griseofulvum; carotanes; sesquiterpenes; anti-food allergy
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Xing, C.-P.; Xie, C.-L.; Xia, J.-M.; Liu, Q.-M.; Lin, W.-X.; Ye, D.-Z.; Liu, G.-M.; Yang, X.-W. Penigrisacids A–D, Four New Sesquiterpenes from the Deep-Sea-Derived Penicillium griseofulvum. Mar. Drugs 2019, 17, 507.

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