Special Issue "Genomic Impact of Transposable Elements"

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Genetics and Genomics Research".

Deadline for manuscript submissions: 21 December 2020.

Special Issue Editor

Dr. Kyudong Han
Website
Guest Editor
Department of Nanobiomedical Science , BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam, 31116, Korea
Interests: comparative genomics; transposable element; genomic instability; genomic rearrangement; species-specific transposable element; molecular marker; phylogenetic analysis

Special Issue Information

Dear Colleagues,

Transposable elements (TEs) have been found in a variety of genomes. TEs are a major source of genetic diversity in eukaryotes. TEs have played an important role in the diversification and enrichment of mammalian transcriptomes. These elements are associated with genomic instability, cancer, epigenetics, gene expression, biomarkers, and DNA repair. We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand TEs’ significance in the host genome. We are interested in articles that explore aspects of genomic/genetic diversity mediated by TEs in all mammals. Potential topics include but are not limited to:

  • Genomic rearrangement by transposable elements;
  • Phylogenetic relationship based on transposable elements;
  • Genetic conflict between host and transposable elements;
  • Role of transposable elements in host factors and epigenetics;
  • Population genetics study by transposable elements;
  • Transposable element research by next-generation sequencing;
  • Transposable elements as a molecular biomarker.

Dr. Kyudong Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

Open AccessReview
Bioinformatics Analysis of Evolution and Human Disease Related Transposable Element-Derived microRNAs
Life 2020, 10(6), 95; https://doi.org/10.3390/life10060095 - 25 Jun 2020
Abstract
Transposable element (TE) has the ability to insert into certain parts of the genome, and due to this event, it is possible for TEs to generate new factors and one of these factors are microRNAs (miRNA). miRNAs are non-coding RNAs made up of [...] Read more.
Transposable element (TE) has the ability to insert into certain parts of the genome, and due to this event, it is possible for TEs to generate new factors and one of these factors are microRNAs (miRNA). miRNAs are non-coding RNAs made up of 19 to 24 nucleotides and numerous miRNAs are derived from TE. In this study, to support general knowledge on TE and miRNAs derived from TE, several bioinformatics tools and databases were used to analyze miRNAs derived from TE in two aspects: evolution and human disease. The distribution of TEs in diverse species presents that almost half of the genome is covered with TE in mammalians and less than a half in other vertebrates and invertebrates. Based on selected evolution-related miRNAs studies, a total of 51 miRNAs derived from TE were found and analyzed. For the human disease-related miRNAs, total of 34 miRNAs derived from TE were organized from the previous studies. In summary, abundant miRNAs derived from TE are found, however, the function of miRNAs derived from TE is not informed either. Therefore, this study provides theoretical understanding of miRNAs derived from TE by using various bioinformatics tools. Full article
(This article belongs to the Special Issue Genomic Impact of Transposable Elements)
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