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Life
Special Issues
Obstetrics and Gynecology Medicine: From Bench to Bedside—3rd Edition
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Obstetrics and Gynecology Medicine: From Bench to Bedside—3rd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 15 September 2026 | Viewed by 1824

Editors

Dr. Stefano Canosa

E-Mail Website
Guest Editor
1. IVIRMA Global Research Alliance, Livet, Via Tiziano Vecellio 3, 10126 Turin, Italy
2. Obstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant’Anna Hospital, University of Turin, 10126 Turin, Italy
Interests: embryo selection; fertility preservation; reproductive genetics; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Dr. Anna Maria Nuzzo

E-Mail Website
Guest Editor
Department of Surgical Sciences, University of Turin, 10126 Turin, Italy
Interests: fetal–maternal medicine; human pregnancy; placenta physiopathology; placental-derived mesenchymal stromal cells (PDMSCs)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the continued success of the second edition of “Obstetrics and Gynecology Medicine: From Bench to Bedside” (https://www.mdpi.com/journal/life/special_issues/28513V6RW5), we are now preparing the third edition and would like to invite you to submit your research for consideration.

This Special Issue continues to highlight the importance of translational research, which aims to bridge the gap between laboratory studies and clinical demands by converting the achievements of basic science into everyday clinical practice. An efficient translational process is sustained by the mutual synergy of academic laboratory research and public/private hospitals. However, the process of transforming research innovation into new health products, as well as diagnostic and therapeutic strategies, remains a major issue in contemporary biomedical medicine. Among different fields of applications, over the last few decades, obstetrics and gynecology have experienced a dramatic increase in several clinical and technical upgrades based on translational research discoveries. Improvements in the quality of life of cancer patients, treatments for pathological pregnancies, drug discoveries, identification of new diagnostic and/or prognostic biomarkers, stem cell applications, the discovery of new molecular pathways involved in obstetrics and gynecology pathophysiology, and automation in assisted reproductive technologies represent only a few examples of the clinical application of basic research. This Special Issue aims to collect original papers and innovative review articles detailing the use of basic research in translational studies of obstetrics and gynecology to assist and support clinical practice in the near future.

Dr. Stefano Canosa
Dr. Anna Maria Nuzzo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstetrics
  • gynecology
  • translational research
  • translational medicine

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Published Papers (4 papers)

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Research

12 pages, 647 KB  
Article
Maternal Salivary Glutamate in Women Undergoing Vaginal Delivery: A Comparison Between Epidural Labor Analgesia and Systemic Morphine Analgesia
by Mohammad Al Hazaymeh, Omar F. Altal, Atef F. Hulliel, Rami K. Jadallah, Ahmed H. Al Sharie, Dana Saleh, Zaina Giabatti, Omar Hazaymeh, Ashraf Al-Issa, Anas Alrusan, Diab Bani Hani and Ala”a Alhowary
Life 2026, 16(7), 1085; https://doi.org/10.3390/life16071085 - 28 Jun 2026
Viewed by 200
Abstract
Introduction: Labor pain is among the most intense forms of acute pain, mediated in part by excitatory glutamatergic neurotransmission within central nociceptive pathways. Glutamate plays a key role in spinal dorsal horn signaling and central sensitization, yet its peripheral dynamics during labor and [...] Read more.
Introduction: Labor pain is among the most intense forms of acute pain, mediated in part by excitatory glutamatergic neurotransmission within central nociceptive pathways. Glutamate plays a key role in spinal dorsal horn signaling and central sensitization, yet its peripheral dynamics during labor and in response to different analgesic modalities remain unclear. This exploratory study aimed to evaluate whether maternal salivary glutamate levels differ between epidural labor analgesia and systemic morphine analgesia during normal vaginal delivery. Method: In this observational comparative study, 36 women were selected to either epidural analgesia (n = 16) or systemic morphine analgesia (n = 20). Salivary samples were collected during active labor and analyzed for glutamate concentration using a validated enzymatic colorimetric assay. Clinical and demographic data were recorded. Non-parametric tests were applied due to non-normal distribution of glutamate levels. Results: Baseline maternal and perinatal characteristics were comparable between groups. Median salivary glutamate levels were higher in the epidural group than in the morphine group (5.32 nmol/µL [IQR 2.83–8.00] vs. 3.99 nmol/µL [IQR 2.26–8.03]), but the difference was not statistically significant (p = 0.599). Glutamate concentrations showed marked inter-individual variability (0.14–29.89 nmol/µL) and a right-skewed distribution. No significant associations were observed between glutamate levels and maternal age, Body Mass Index, gestational age, birth weight, or obstetric comorbidities. Conclusion: In this exploratory cohort, maternal salivary glutamate concentrations did not differ significantly between epidural labor analgesia and systemic morphine analgesia during labor. The variability observed suggests complex and heterogeneous regulation of peripheral glutamatergic activity in parturition. Further larger-scale studies integrating central and peripheral measurements are warranted. Full article
(This article belongs to the Special Issue Obstetrics and Gynecology Medicine: From Bench to Bedside—3rd Edition)
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20 pages, 2473 KB  
Article
Pilot Study on the Effects of First-Line Antituberculosis Drugs and Their Combinations on Selected Reproductive Endpoints in Female Rats
by Elif Esra Uyar, Bulent Yavuzer, Mansura Babayeva, Nurinisa Yucel, Murat Gunay and Halis Suleyman
Life 2026, 16(6), 878; https://doi.org/10.3390/life16060878 - 24 May 2026
Viewed by 344
Abstract
Background: The reproductive toxicity of first-line antituberculosis drugs remains poorly understood, particularly when used in combination. Rifampicin, isoniazid, pyrazinamide, and ethambutol are essential in tuberculosis therapy, but their potential influence on female fertility is uncertain. This pilot study evaluated their effects, given alone [...] Read more.
Background: The reproductive toxicity of first-line antituberculosis drugs remains poorly understood, particularly when used in combination. Rifampicin, isoniazid, pyrazinamide, and ethambutol are essential in tuberculosis therapy, but their potential influence on female fertility is uncertain. This pilot study evaluated their effects, given alone or in dual, triple, and quadruple combinations, on oxidative stress, endocrine markers, and reproductive outcomes in healthy female rats. Materials and Methods: Ninety-six albino Wistar-type female rats were divided into sixteen groups of six animals each and treated with single, dual, triple, or quadruple regimens of first-line antituberculosis drugs for 28 days. After treatment, two sexually mature males were introduced per group, and therapy continued for seven additional days. Serum malondialdehyde (MDA), total glutathione (tGSH), prolactin, and anti-Mullerian hormone (AMH) levels were measured, and fertility outcomes were evaluated. Results: In single-drug groups, MDA increased and tGSH decreased, but detectable infertility was not recorded. Prolactin remained stable except in the pyrazinamide group, where it declined. Dual-drug regimens increased oxidative imbalance; fertility failure occurred only in pyrazinamide-lacking groups and was accompanied by higher prolactin and lower AMH. Triple and quadruple combinations produced prominent oxidative imbalance. In triple-drug regimens, infertility was lower in pyrazinamide-containing groups than in the pyrazinamide-free group, but this pattern was not maintained in the quadruple regimen. Fertility impairment was not consistently aligned with the degree of oxidative stress and may involve prolactin and AMH alterations. Conclusions: These findings suggest that reproductive impairment under these experimental conditions may involve endocrine alterations and cannot be explained solely by serum oxidative imbalance. Pyrazinamide-associated fertility preservation appeared context-dependent and requires further confirmation in larger mechanistic studies with broader reproductive and endocrine assessment. Full article
(This article belongs to the Special Issue Obstetrics and Gynecology Medicine: From Bench to Bedside—3rd Edition)
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26 pages, 5185 KB  
Article
Polymorphism of the FSHB Gene Is Associated with Endometrial Hyperplasia
by Vladimir Churnosov, Maria Churnosova, Evgeny Reshetnikov, Inna Aristova, Kirill Tsoy, Inna Sorokina, Alexey Polonikov, Maria Solodilova, Mikhail Churnosov and Irina Ponomarenko
Life 2026, 16(5), 782; https://doi.org/10.3390/life16050782 - 7 May 2026
Viewed by 532
Abstract
The work was performed to assess the relationship of single-nucleotide polymorphisms (SNPs), which determine the concentration of sex hormones (confirmed in previously performed genome-wide studies (GWASs)), with the risk of endometrial hyperplasia (EH). The objects of the study were 1493 women, of which [...] Read more.
The work was performed to assess the relationship of single-nucleotide polymorphisms (SNPs), which determine the concentration of sex hormones (confirmed in previously performed genome-wide studies (GWASs)), with the risk of endometrial hyperplasia (EH). The objects of the study were 1493 women, of which 520 individuals had EH; the control group consisted of 973 women. Nine SNPs that were GWAS-associated with the level of sex hormones were investigated. The correlations of SNPs that determine the level of sex hormones with EH risk were found: minor polymorphic variants rs11031002 (allele A: OR = 0.45–0.50) and rs11031005 (allele C: OR = 0.05–0.53) of the FSHB gene were associated with a low risk of developing the disease, and the TT*rs11031002-rs11031005 FSHB haplotype, at a level of statistical significance (p = 1 × 10−11) exceeding the GWAS “standard”, increases the EH risk by more than 2.5 times (OR = 2.84). The 16 multilevel SNP interaction exploratory models of nine considered loci were EH-associated (padj-perm < 0.001). Two loci, T>A rs11031002 and T>C rs11031005 FSHB, play a fundamental role in these models (100% and 75% of models, respectively), and two more loci, C>G rs112295236 SLC22A10 and C>A rs117585797 ANO2, are part of more than 30% of all models. Sex hormone-level genetic determinants are involved in numerous EH-significant hormone-mediated molecular pathways (regulation of gene transcription, processes of embryogenesis and development, regulation of metabolism, differentiation and maturation of the epithelium, TGFβ pathway, fat cell differentiation, etc.). In conclusion, for the first time, it was found that the genetic polymorphisms that determine an organism’s sex hormone levels are associated with EH. Full article
(This article belongs to the Special Issue Obstetrics and Gynecology Medicine: From Bench to Bedside—3rd Edition)
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10 pages, 375 KB  
Article
Maternal Salivary Glutamate Concentrations in Cesarean Delivery: A Prospective Comparison Between Spinal and General Anesthesia
by Diab Bani Hani, Omar F. Altal, Atef F. Hulliel, Tala Ahmed, Anas Alrusan, Mohammad Al Hazaymeh, Fatima Albusta, Taqwa Haweeleh and Ala”a Alhowary
Life 2026, 16(5), 748; https://doi.org/10.3390/life16050748 - 1 May 2026
Viewed by 316
Abstract
Background: Cesarean delivery is commonly performed under either spinal or general anesthesia. While both techniques are widely used, their differential effects on maternal neurochemical profiles, particularly excitatory neurotransmitters such as glutamate, remain incompletely understood. Glutamate plays a central role in stress response, nociception, [...] Read more.
Background: Cesarean delivery is commonly performed under either spinal or general anesthesia. While both techniques are widely used, their differential effects on maternal neurochemical profiles, particularly excitatory neurotransmitters such as glutamate, remain incompletely understood. Glutamate plays a central role in stress response, nociception, and neuroendocrine regulation. This study aimed to compare maternal salivary glutamate concentrations between spinal and general anesthesia during cesarean delivery. Method: In this prospective study, 66 women undergoing cesarean delivery were included: 32 received spinal anesthesia and 34 received general anesthesia. Unstimulated saliva samples were collected perioperatively and analyzed using a colorimetric enzymatic assay. Clinical and demographic variables were extracted from electronic medical records. Results: Baseline maternal and neonatal characteristics were comparable between groups (all p > 0.05). Glutamate concentrations were not normally distributed. Median salivary glutamate levels were significantly higher in the general anesthesia group compared with the spinal anesthesia group (8.05 nmol/µL [IQR 4.81–11.69] vs. 5.19 nmol/µL [IQR 3.05–8.39]; p = 0.041) After adjustment for maternal and perinatal covariates, anesthesia type was not independently associated with glutamate levels (p = 0.21). Conclusion: General anesthesia was associated with higher unadjusted maternal salivary glutamate levels compared with spinal anesthesia during cesarean delivery; however, this association did not persist after multivariable adjustment. These findings suggest that anesthesia technique alone may not independently influence perioperative glutamatergic responses. Further research is warranted to clarify the clinical significance of these neurochemical changes for maternal and neonatal outcomes. Full article
(This article belongs to the Special Issue Obstetrics and Gynecology Medicine: From Bench to Bedside—3rd Edition)
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