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Healthcare
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Fertility Preservation and Sterility Treatment
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Fertility Preservation and Sterility Treatment

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Nursing".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 7041

Special Issue Editor

Dr. Stefano Canosa

E-Mail Website
Guest Editor
IVIRMA Global Research Alliance, LIVET, 10126 Turin, Italy
Interests: reproductive medicine; fertility preservation; stem cell therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Cryopreservation techniques are routinely performed today to store reproductive cells and embryos for many medical or social reasons, including fertility preservation in patients at risk of premature fertility loss, such as patients facing gonadotoxic treatments, women delaying childbearing for personal, professional, financial or psychological reasons, and egg donation programs. In addition, the use of this technology has improved cumulative live birth rates by allowing repeated embryo transfers with surplus frozen embryos from a single ovarian stimulation cycle in patients with impaired endometrial receptivity or undergoing preimplantation genetic testing (PGT). Some approaches are currently under investigation, including the use of cryopreserved gonadal tissue or cells, the study of molecular processes involved in in vitro germ cell maturation, and new strategies to optimize the pregnancy chances in assisted reproductive technologies. For this Special Issue, we hope to encourage submissions focusing on current developments in the field of fertility preservation and on new therapeutic perspectives for fertility restoration in humans. Both original research and review articles are welcomed. 

You may choose our Joint Special Issue in Life.

Dr. Stefano Canosa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fertility preservation
  • oncofertility
  • cryopreservation
  • basic research
  • gonadotoxicity
  • oocyte cryopreservation
  • sperm cryopreservation
  • ovarian tissue transplantation
  • assisted reproductive technologies

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Published Papers (2 papers)

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Review

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14 pages, 577 KB  
Review
Innovative Strategies for Fertility Preservation in Female Cancer Survivors: New Hope from Artificial Ovary Construction and Stem Cell-Derived Neo-Folliculogenesis
by Stefano Canosa, Alberto Revelli, Gianluca Gennarelli, Gennaro Cormio, Vera Loizzi, Francesca Arezzo, Easter Anna Petracca, Andrea Roberto Carosso, Danilo Cimadomo, Laura Rienzi, Alberto Vaiarelli, Filippo Maria Ubaldi and Erica Silvestris
Healthcare 2023, 11(20), 2748; https://doi.org/10.3390/healthcare11202748 - 17 Oct 2023
Cited by 9 | Viewed by 4433
Abstract
Recent advances in anticancer treatment have significantly improved the survival rate of young females; unfortunately, in about one third of cancer survivors the risk of ovarian insufficiency and infertility is still quite relevant. As the possibility of becoming a mother after recovery from [...] Read more.
Recent advances in anticancer treatment have significantly improved the survival rate of young females; unfortunately, in about one third of cancer survivors the risk of ovarian insufficiency and infertility is still quite relevant. As the possibility of becoming a mother after recovery from a juvenile cancer is an important part of the quality of life, several procedures to preserve fertility have been developed: ovarian surgical transposition, induction of ovarian quiescence by gonadotropin-releasing hormone agonists (GnRH-a) treatment, and oocyte and/or ovarian cortical tissue cryopreservation. Ovarian tissue cryostorage and allografting is a valuable technique that applies even to prepubertal girls; however, some patients cannot benefit from it due to the high risk of reintroducing cancer cells during allograft in cases of ovary-metastasizing neoplasias, such as leukemias or NH lymphomas. Innovative techniques are now under investigation, as in the construction of an artificial ovary made of isolated follicles inserted into an artificial matrix scaffold, and the use of stem cells, including ovarian stem cells (OSCs), to obtain neo-folliculogenesis and the development of fertilizable oocytes from the exhausted ovarian tissue. This review synthesizes and discusses these innovative techniques, which potentially represent interesting strategies in oncofertility programs and a new hope for young female cancer survivors. Full article
(This article belongs to the Special Issue Fertility Preservation and Sterility Treatment)
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9 pages, 3002 KB  
Brief Report
Optimizing the Ovarian Tissue Cryopreservation in the ‘Oncofertility’ Institutional Program at an Italian National Cancer Institute
by Erica Silvestris, Carla Minoia, Giuseppe De Palma, Ondina Popescu, Anna Altavilla, Attilio Guarini, Fabio Pavone, Vera Loizzi, Gennaro Cormio and Raffaella Depalo
Healthcare 2023, 11(20), 2727; https://doi.org/10.3390/healthcare11202727 - 13 Oct 2023
Viewed by 1575
Abstract
Background: The majority of female cancer patients undergoing anticancer treatments are at risk of experiencing ‘cancer treatment-related infertility’, which can result in permanent damage to their reproductive prospects. Among the fertility preservation methods, ovarian tissue cryopreservation (OTC) has emerged as an alternative for [...] Read more.
Background: The majority of female cancer patients undergoing anticancer treatments are at risk of experiencing ‘cancer treatment-related infertility’, which can result in permanent damage to their reproductive prospects. Among the fertility preservation methods, ovarian tissue cryopreservation (OTC) has emerged as an alternative for these patients. The Cancer Institute of Bari initiated a research program to assess the feasibility of OTC. This study compares the viability of ovarian cortical fragments cryopreserved using slow freezing (SF) and ultra-rapid freezing (URF) methods. Methods: Ovarian cortex biopsies were obtained from 11 fertile women enrolled in our oncofertility service between June 2022 and January 2023. After tissue collection, a histological assessment was performed before cryopreservation. OTC was carried out using both SF and URF methods. Six months later, thawed samples were evaluated for follicle counts and histological integrity. Results: No statistically significant difference was observed in the proportion of intact follicles (means of 31.5% and 73.0% in the SF and URF groups, respectively; p = 0.064). However, there was a significant difference in the number of follicles between the SF group (n = 149) and the URF group (n = 37) (p = 0.046). Conclusions: We assessed the viability of ovarian cortex after freezing and thawing, focusing on the structural integrity of follicles. Our findings suggest that there are no significant differences between the SF and URF methods. Full article
(This article belongs to the Special Issue Fertility Preservation and Sterility Treatment)
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