Special Issue "Translational Science: Approaches to Reducing Burden Caused by Fungal Diseases"
A special issue of Journal of Fungi (ISSN 2309-608X).
Deadline for manuscript submissions: closed (28 February 2018)
Interests: antifungals; drug resistance; bioinformatics; mitochondria
Special Issues, Collections and Topics in MDPI journals
I have chosen author contributions for this Special Issue based on their translational implications that seek to reduce fungal burden. The Special Issue will be composed of 12 submitted papers (see attachment). The submitted papers will be organized in two parts, those being: 1) patients: Detection and therapies for the invasive fungal infections, candidiasis, aspergillosis and cryptococcosis; and 2) papers related to the host-fungal-commensal interface. Part 1 will include papers on the global incidence of fungal infections, patient susceptibility (genetic predisposition), antifungal susceptibilities among Candida species, PCR based methods of detection, immunotherapy, and prophylaxis antifungal therapy. Part 2 focuses upon the basic science of fungal pathogenesis and includes papers on microbiomes (2 papers), fungal-specific drug targets, microevolution of virulence, cytokine receptor signaling, and morphotype functions of C. neoformans. Part 2 papers were selected based on ideas that may have translational implications.
The subjects of Part 1 are based upon current understanding primarily of candidemia. There is now sufficient literature to discuss gene SNPs that identify high-risk patients. The fairly new PCR-based assay to aid in the diagnosis of invasive candidiasis will be discussed. Controversy exists about how to treat culture-negative invasive candidiasis; one suggestion is prophylaxis treatment with antifungals. Alternatives to drug treatment include immunotherapy.
In part 2, the microbiomes associated with candidiasis and aspergillosis will be featured. Exploitation of fungal-specific targets in new drug therapy will in part emphasize the bioinformatics approach to identify these targets. Another paper will explain the concept of microevolution that describes the conversion of avirulence to virulence within macrophages. Cell transitional growth has been the subject of numerous reviews. New data suggest that growth transitional types in C. neoformans have different functions in pathogenesis.
Prof. Dr. Richard Calderone
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- fungal pathogenesis
- candidiasis, aspergillosis and cryptococcosis
- fungal burden
- fungal detection and and therapies
- prophylaxis treatment
- Antifungal and vaccine development