Fungal Pathogenicity and Host Defense: A Molecular Perspective

Dear Colleagues,

Fungal pathogenicity is driven by a complex interplay of molecular mechanisms that enable invasion, immune evasion, and tissue damage. Pathogenic fungi deploy virulence factors, such as adhesins, hydrolytic enzymes, and toxins, to breach host barriers and establish an infection. In parallel, host immune responses are activated, which detect fungal pathogen-associated molecular patterns (PAMPs) such as β-glucans and mannans. This recognition triggers innate immune cascades, resulting in cytokine production, phagocytosis, and the enhancement of adaptive immunity. However, fungi can subvert these defenses via immune modulation, antigenic variation, and biofilm formation. Understanding the molecular crosstalk between fungal pathogens and host immunity is critical for identifying novel therapeutic targets and improving antifungal strategies. Recent advances in genomics, transcriptomics, and immunology have illuminated key aspects of this dynamic interaction, offering insights into host susceptibility and resistance.

This Special Issue, titled “Fungal Pathogenicity and Host Defense: A Molecular Perspective”, aims to highlight cutting-edge research on fungal virulence mechanisms and host defense pathways, fostering a deeper understanding of fungal diseases and guiding the development of innovative interventions. Some of its focal points include, but are not limited to, the following:

1. Fungal pathogenesis.
2. Fungal virulence factors.
3. Innate response to fungi.
4. Adaptive immune response to fungi.
5. Invasive fungal infections.
6. Fungal immune modulation.
7. Fungal immunotherapy.

Reviews, original research, and communications are all welcome.

Dr. Shakti Singh
Dr. Michael K. Mansour
Guest Editors

Manuscript Submission Information

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