Antifungal Agents Recently Approved or Under Development, 2nd Edition
A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 66
Special Issue Editor
Interests: antifungal susceptibility testing and development of ECVs for fungal species; antifungal resistance; medical mycology; epidemiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since the previous edition of this Special Issue, numerous clinical trials have been conducted on several agents for combating the following fungal infections: Three studies evaluated the efficacy and safety of osteseconazole (one study against fluconazole) in the treatment of recurrent vulvovaginal candidiasis. Four studies investigated ibrexafungerp for the treatment of vulvovaginal candidiasis, including one study of the efficacy and safety of oral ibrexafungerp (SCY-078), as well as a phase III CANDLE study on the prevention of recurrent vaginal yeast infections.
The literature reports two studies of the efficacy and safety of oral ibrexafungerp for patients with invasive candidiasis or candidaemia caused by Candida auris. A phase III randomized double-blind study was reported for patients with invasive candidiasis treated with IV echinocandin followed by ibrexafungerp or oral fluconazole. Four studies reported rezafungin-versus-caspofungin data for the treatment of candidaemia and/or invasive candidiasis, including one study that examined the efficacy and safety of the two agents.
Another study investigated oral lipid nanocrystal amphotericin B for the treatment of cryptococcal meningitis.
We found several clinical studies of filamentous fungi. Four studies with olorofim (F901318) reported the following: in vitro activity against difficult-to-treat aspergillus isolates, scedpsporium and Lomentospora prolificans isolates, the molecular mechanisms of acquired olorofim resistance, and the treatment of invasive mold infections in patients with limited or no treatment options.
Finally, two studies investigated opelconazole (PC945) activity in combination with other antifungal therapies for the treatment of refractory invasive pulmonary aspergillosis as well as the in vitro and in vivo antifungal activity of inhaled olorofim.
Any other data that should be reported for the filamentous fungi with the new agents will be appreciated.
Dr. Ana V. Espinel-Ingroff
Guest Editor
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Keywords
- antifungal agents
- osteseconazole
- ibrexafungerp
- olorofim
- opelconazole
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