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Clinical and Epidemiological Study of Mycoses
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Clinical and Epidemiological Study of Mycoses

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1598

Special Issue Editors

Dr. Yaxsier de Armas

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Guest Editor
Instituto de Patología Infecciosa y Experimental “Francisco Ruiz Sánchez”, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44100, Mexico
Interests: fungi; infectious diseases; microbiology
Dr. Enrique J Calderón

E-Mail Website
Guest Editor
Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, 41013 Seville, Spain
Interests: pneumocystis; dihydropteroate synthase; pneumonia; infection
Special Issues, Collections and Topics in MDPI journals
Dr. Héctor Raúl Pérez-Gómez

E-Mail Website
Guest Editor
Instituto de Patología Infecciosa y Experimental “Francisco Ruiz Sánchez”, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44100, Mexico
Interests: infectious diseases; microbiology; tropical medicine

Special Issue Information

Dear Colleagues,

Fungal diseases are a major public health problem worldwide, with increasing incidence and mortality rates, partially due to delays in pathogen diagnosis and a lack of clinician experience in identifying and treating the disease. In recent years, the widespread use of immunosuppressive agents, advances in organ transplantation, and the development of intensive care technologies have led to a marked increase in the incidence of invasive fungal diseases, posing significant challenges to clinical management.

This special issue aims to summarize the latest research findings in the field of fungal diseases, covering advances in clinical features, diagnostic methods, therapeutic strategies, and epidemiology.

Dr. Yaxsier de Armas
Dr. Enrique J Calderón
Dr. Héctor Raúl Pérez-Gómez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • clinical
  • fungal diseases
  • epidemiology
  • mycoses

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Published Papers (2 papers)

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16 pages, 1675 KiB  
Article
Virulence Factors and Molecular Identification of Candida Species Causing Candidemia in Honduras
by José Fernando Chávez, Bryan Ortiz, Roque López, Carlos Muñoz, Kateryn Aguilar, Isis Laínez-Arteaga, Celeste Galindo, Luis Rivera, Manuel G. Ballesteros-Monrreal, Kathy Montes, Mauricio Hernández, Asly Villeda Barahona, Stephanie Hereira-Pacheco and Gustavo Fontecha
J. Fungi 2025, 11(7), 470; https://doi.org/10.3390/jof11070470 - 20 Jun 2025
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Abstract
Invasive fungal infections (IFIs), primarily caused by Candida species, represent a significant global public health concern due to their high mortality rates and growing antifungal resistance. In Honduras, data on their epidemiology remains scarce. This study aimed to characterize Candida species associated with [...] Read more.
Invasive fungal infections (IFIs), primarily caused by Candida species, represent a significant global public health concern due to their high mortality rates and growing antifungal resistance. In Honduras, data on their epidemiology remains scarce. This study aimed to characterize Candida species associated with candidemia and assess key virulence factors. A total of 80 clinical isolates were collected from four hospitals in Honduras’s major cities, Tegucigalpa and San Pedro Sula. Identification was performed using both phenotypic and molecular methods. Hemolytic activity, phospholipase and protease production, and biofilm formation were evaluated. C. albicans and C. tropicalis were the most prevalent species (30% each), followed by C. parapsilosis (27.5%). Phenotypic methods misidentified 13.8% of the isolates. Most strains (96.3%) exhibited strong hemolytic activity. C. albicans showed the highest phospholipase activity, while C. tropicalis was the most robust film producer. These findings highlight an evolving epidemiological landscape characterized by an increasing prevalence of non-albicans Candida species, often less susceptible to antifungal agents, and diverse virulence profiles such as strong biofilm formation. This underscores the clinical need for accurate species-level identification through molecular diagnostics and ongoing surveillance to guide targeted antifungal therapy and enable early, locally adapted interventions. Full article
(This article belongs to the Special Issue Clinical and Epidemiological Study of Mycoses)
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12 pages, 719 KiB  
Brief Report
Epidemiology and Characteristics of Invasive Yeast Infections in Patients with Hematologic Diseases: 12-Year Single-Center Retrospective Cohort Study
by Dong Young Kim, Keon Oh, Minseung Song, Hyemin Kweon, Dukhee Nho, Hanter Hong, Raeseok Lee, Dong-Gun Lee and Sung-Yeon Cho
J. Fungi 2025, 11(8), 585; https://doi.org/10.3390/jof11080585 - 8 Aug 2025
Viewed by 284
Abstract
Invasive yeast infections (IYIs) remain a significant cause of morbidity and mortality in patients with hematologic diseases. We retrospectively analyzed 193 IYI episodes among 179 patients admitted to a tertiary hematology hospital (2012–2023). Candida species accounted for 91.7% (n = 177), while non- [...] Read more.
Invasive yeast infections (IYIs) remain a significant cause of morbidity and mortality in patients with hematologic diseases. We retrospectively analyzed 193 IYI episodes among 179 patients admitted to a tertiary hematology hospital (2012–2023). Candida species accounted for 91.7% (n = 177), while non-Candida yeasts comprised 8.3% (n = 16). Among invasive candidiasis, non-albicans Candida spp. were predominant, representing 76.8% (136/177), with C. tropicalis (36.2%, 64/177) being the most frequently isolated species. Among non-Candida yeasts, Cryptococcus neoformans (n = 10) was the most commonly identified pathogen. The incidence and 42-day mortality rate of IYIs were 0.199 and 0.095 per 1000 patient-days, respectively. The 42-day case-fatality rate remained high at 47.7%. In categorical analysis, age >65 years, corticosteroid use, elevated lactate (>2 mmol/L), neutropenia (<500/mm3), vasopressor use, and mechanical ventilation were more common in non-survivors. Primary bloodstream infections were more frequent in non-survivors, whereas catheter-related and abdominal-origin infections were predominant among survivors. Concomitant bacteremia was observed in 32.6% of IYI cases (n = 63), with Enterococcus faecium being the most frequently isolated co-pathogen. Our findings illustrate the evolving epidemiology of IYIs in hematologic patients, marked by the emergence of C. tropicalis as the predominant species, sustained mortality, and frequent bacterial co-infections, collectively reflecting the substantial clinical burden of IYIs. Full article
(This article belongs to the Special Issue Clinical and Epidemiological Study of Mycoses)
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