New Molecular Perspectives on Multidrug-Resistance in Postharvest Fungi

Dear Colleagues,

Fungi are a great threat to the post-harvest industry, causing high economic losses. Management options are limited due to resistance to fungicides. The multidrug resistance (MDR) phenotype is the main factor responsible for the failure of antifungal control. The main mechanisms of resistance to antifungals are related to the presence of transport proteins in the plasma membrane, which extrude drugs from the intracellular medium and, therefore, prevent them from reaching the necessary concentration that would allow them to be effective against fungi. However, other mechanisms can be observed, such as point mutations in the binding targets of certain fungicides. Due to the importance of MDRs for the control of fungal pathogens during postharvest, the discovery of new molecules capable of inhibiting efflux transporters and/or new targets of action emerges as a promising strategy to strengthen the antifungal arsenal.

This Special Issue aims to present and promote research on fungicide resistance molecular mechanisms in order to encourage research into alternatives that block the multidrug resistance phenotype.

Dr. Paloma Sánchez-Torres
Guest Editor

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