Candidiasis: Changes and Challenges in Its Epidemiology, Pathogenesis, Diagnosis, Treatment and Prevention

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 223

Special Issue Editor


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Guest Editor
Department of Immunology, Microbiology and Parasitology, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, 48080 Bilbao, Spain
Interests: medical mycology; mycoses; candida; candidiasis; mycobiome; biofilms; diagnosis; antifungal agents

Special Issue Information

Dear Colleagues,

Candidiasis presents a serious threat to public health and is associated with prolonged hospitalizations and considerable morbidity and mortality rates. The epidemiology of candidiasis has changed significantly in recent decades. Candida albicans remains the most frequent etiology, but its relative prevalence has decreased. Candidozyma auris (Candida auris) is a new emerging antifungal resistant species, with a great capacity for persistence and nosocomial transmission, causing candidiasis outbreaks in hospitals worldwide. For these reasons, the World Health Organization has included both species in their list of priority fungal pathogens. Candidiasis caused by C. albicans and C. auris have similarities, but there are also important differences in their epidemiology, pathogenesis, diagnostics and therapeutics. The aim of this Special Issue is to provide the latest knowledge on candidiasis induced by both species to improve the diagnostic and therapeutic management of these patients through comprehensive reviews, original studies, and novel perspectives.

Prof. Dr. Guillermo Quindos
Guest Editor

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Keywords

  • medical mycology
  • mycoses
  • candida
  • candidiasis
  • mycobiome
  • biofilms
  • diagnosis
  • antifungal agents

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Published Papers (1 paper)

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Research

20 pages, 3840 KiB  
Article
Vacuolar Proteases of Candida auris from Clades III and IV and Their Relationship with Autophagy
by Daniel Clark-Flores, Alvaro Vidal-Montiel, Ricardo Mondragón-Flores, Eulogio Valentín-Gómez, César Hernández-Rodríguez, Margarita Juárez-Montiel and Lourdes Villa-Tanaca
J. Fungi 2025, 11(5), 388; https://doi.org/10.3390/jof11050388 - 18 May 2025
Viewed by 54
Abstract
Candida auris is a multidrug-resistant pathogen with a high mortality rate and widespread distribution. Additionally, it can persist on inert surfaces for extended periods, facilitating its transmissibility in hospital settings. Autophagy is a crucial cellular mechanism that enables fungal survival under adverse conditions. [...] Read more.
Candida auris is a multidrug-resistant pathogen with a high mortality rate and widespread distribution. Additionally, it can persist on inert surfaces for extended periods, facilitating its transmissibility in hospital settings. Autophagy is a crucial cellular mechanism that enables fungal survival under adverse conditions. A fundamental part of this process is mediated by vacuolar proteases, which play an essential role in the degradation and recycling of cellular components. The present work explores the relationship between C. auris vacuolar peptidases and autophagy, aiming to establish a precedent for understanding the survival mechanisms of this emerging fungus. Thus, eight genes encoding putative vacuolar peptidases in the C. auris genomes were identified: PEP4, PRB1, PRC1, ATG42, CPS, LAP4, APE3, and DAP2. Analysis of the protein domains and their phylogenetic relationships suggests that these enzymes are orthologs of Saccharomyces cerevisiae vacuolar peptidases. Notably, both vacuolar protease gene expression and the proteolytic activity of cell-free extracts increased under nutritional stress and rapamycin. An increase in the expression of the ATG8 gene and the presence of autophagic bodies were also observed. These results suggest that proteases could play a role in yeast autophagy and survival during starvation conditions. Full article
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