Special Issue "Functional Engineering and Biomechanical Features of Biomaterials Applied to Dental Practice"

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (20 December 2018)

Special Issue Editors

Guest Editor
Prof. Dr. Marco Cicciu

Department of Biomedical and Dental Sciences, Morphological and Functional Images, School of Dentistry, University of Messina, Policlinico G. Martino, Via Consolare Valeria, 98100 Me, Italy
Website | E-Mail
Interests: Biomaterials, Dental Prosthesis, Material Sciences, Material Engineering, Tissue Engineering, Growth Factor, Regenerative Medicine
Guest Editor
Prof. Giacomo Risitano

Head of Automotive Design Teaching and Mechanical Project Teaching, Department of Engineering, Messina University MESSINA, 98100, ME, ITALY
E-Mail
Interests: biomaterials; biomechanics; tissue engineering; fractures

Special Issue Information

Dear Colleagues,

Recently, numerous types of biomaterials, such as natural and artificial polymers, ceramics, metals, dental implants, prosthodontics components, radiological devices surgical tools, and orthodontic devices have been developed for use in daily dental clinical practice.

I am honored to invite contributors and researchers to submit original research articles, as well as review manuscripts, to investigate and research topics dealing with engineering and functional biomaterial related to all dental disciplines, as well as periodontal surgery, prosthodontics, conservative and endodontic devices, or orthodontic tools. The discoveries regarding bioengineering function, material stress, safety and long-term predictability of dental applied devices, will be accepted for submission.

The topic is widely present in the recent international literature and, for this reason, this Special Issue is directed at dental researchers, as well as bioengineering researchers, in order to have a complete understanding of the state-of-the-art of dental biomaterials and their mechanical, chemical, and engineering features.

Authors can submit their manuscript by accessing the MDPI submission system https://www.mdpi.com/journal/jfb/special_issues

Prof. Marco Cicciù
Prof. Giacomo Risitano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 850 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • dental materials
  • tissue engineering
  • mechanical engineering
  • biomechanics
  • bioengineering
  • virtual models
  • prosthodontics

Published Papers (3 papers)

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Research

Open AccessFeature PaperArticle
Evaluation of Osteoconduction of Biphasic Calcium Phosphate Ceramic in the Calvaria of Rats: Microscopic and Histometric Analysis
J. Funct. Biomater. 2019, 10(1), 7; https://doi.org/10.3390/jfb10010007
Received: 18 December 2018 / Revised: 9 January 2019 / Accepted: 15 January 2019 / Published: 17 January 2019
Cited by 1 | PDF Full-text (3525 KB) | HTML Full-text | XML Full-text
Abstract
(1) Background: Evaluate the osteoconduction capability of a biphasic calcium phosphate (BCP) ceramic composed of hydroxyapatite and β-tricalcium phosphate 60%/40% in a rat model. (2) Methods: In the calvarial bone of 54 adult male rats, 7-mm diameter critical size defects were performed. The [...] Read more.
(1) Background: Evaluate the osteoconduction capability of a biphasic calcium phosphate (BCP) ceramic composed of hydroxyapatite and β-tricalcium phosphate 60%/40% in a rat model. (2) Methods: In the calvarial bone of 54 adult male rats, 7-mm diameter critical size defects were performed. The animals were randomly allocated to three experimental groups according to the type of material: blood clot (BCG), blood clot covered with a bovine-derived collagen membrane (MBCG), and BCP ceramic covered with a bovine-derived collagen membrane (BCPG). In each group, 6 animals were euthanatized at post-operative days 7, 30, and 60 for histological and histometric analysis. (3) Results: The qualitative analysis revealed the persistence of the collagen membrane at seven days, with no relevant newly bone formation in all groups. At 30 days, centripetal bone formation was observed residual particles of the biomaterial surrounded by fibroblasts noted in the BCPG. At 60 days, while BCG and MBCG showed a partial maturation with the central part of the defect populated by a fibrous connective tissue, in the BCPG the critical area was entirely occupied by newly formed bone. In the intra groups analysis was noted a significant increase in new bone formation during the experimental period (p < 0.05). At 60 days, BCPG showed a higher percentage area of new bone formation (p < 0.05). (4) Conclusion: BCP promoted a new bone formation by osteoconduction and might be considered a valid alternative in bone regeneration procedures. Full article
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Open AccessArticle
Assessment of Dental Implants with Modified Calcium-Phosphate Surface in a Multicenter, Prospective, Non-Interventional Study: Results up to 50 Months of Follow-Up
J. Funct. Biomater. 2019, 10(1), 5; https://doi.org/10.3390/jfb10010005
Received: 26 November 2018 / Revised: 3 January 2019 / Accepted: 4 January 2019 / Published: 11 January 2019
PDF Full-text (1450 KB) | HTML Full-text | XML Full-text
Abstract
Prescription of implant treatments is very widespread at present, mainly due to the low rate of annual loss and, to date, few studies have assessed their survival in the routine clinical practice of dentistry. The purpose of this observational study was to evaluate [...] Read more.
Prescription of implant treatments is very widespread at present, mainly due to the low rate of annual loss and, to date, few studies have assessed their survival in the routine clinical practice of dentistry. The purpose of this observational study was to evaluate the effectiveness of dental implants with a calcium-phosphate surface in the daily practice of dental clinics. A multicenter, prospective, non-interventional, observational study was performed, in which three experienced practitioners (one maxillofacial and two oral surgeons) inserted implants using standard external and internal hexagon connections in adult patients requiring ≥1 osseointegrated implants to replace missing teeth. Follow-up was performed for 24 months after implant loading. Two hundred and twelve subjects were included (51.5% men), with a mean age of 51.2 ± 11.90 years, in whom 544 implants were inserted. 87.2% of the patients received 1–4 implants. The preferred connection system was internal hexagon (73.5%). There were nine failures, with an interval survival rate (ISR) at 24 months of 100% and a cumulative survival rate (CSR) of 98.3%. In conclusion, implants with a modified calcium-phosphate surface are associated with a high rate of survival and may be considered a method of choice in clinical practice. Full article
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Open AccessFeature PaperArticle
Three-Dimensional Bone Substitutes for Oral and Maxillofacial Surgery: Biological and Structural Characterization
J. Funct. Biomater. 2018, 9(4), 62; https://doi.org/10.3390/jfb9040062
Received: 27 September 2018 / Revised: 29 October 2018 / Accepted: 2 November 2018 / Published: 8 November 2018
Cited by 2 | PDF Full-text (2358 KB) | HTML Full-text | XML Full-text
Abstract
Background: Bone substitutes, either from human (autografts and allografts) or animal (xenografts) sources, suffer from inherent drawbacks including limited availability or potential infectivity to name a few. In the last decade, synthetic biomaterials have emerged as a valid alternative for biomedical applications in [...] Read more.
Background: Bone substitutes, either from human (autografts and allografts) or animal (xenografts) sources, suffer from inherent drawbacks including limited availability or potential infectivity to name a few. In the last decade, synthetic biomaterials have emerged as a valid alternative for biomedical applications in the field of orthopedic and maxillofacial surgery. In particular, phosphate-based bone substitution materials have exhibited a high biocompatibility due to their chemical similitude with natural hydroxyapatite. Besides the nature of the biomaterial, its porous and interconnected architecture is essential for a correct osseointegration. This performance could be predicted with an extensive characterization of the biomaterial in vitro. Methods: In this study, we compared the biological, chemical, and structural features of four different commercially available bone substitutes derived from an animal or a synthetic source. To this end, µ-CT and SEM were used to describe the biomaterials structure. Both FTIR and EDS analyses were carried out to provide a chemical characterization. The results obtained by these techniques were correlated with cell adhesion and proliferation of the osteosarcoma MG-63 human cell line cultured in vitro. Results: The findings reported in this paper indicate a significant influence of both the nature and the structure of the biomaterials in cell adhesion and proliferation, which ultimately could affect the clinical performance of the biomaterials. Conclusions: The four commercially available bone substitutes investigated in this work significantly differed in terms of structural features, which ultimately influenced in vitro cell proliferation and may so affect the clinical performance of the biomaterials. Full article
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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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