Special Issue "Th17 Cell in Autoimmune and Inflammatory Diseases"
Deadline for manuscript submissions: closed (30 April 2017)
Dr. Shigeru Kotake
Tokyo Women's Medical University, Institute of Rheumatology, Tokyo, Japan
Interests: immunology, especially IL-17 and Th17, and bone cell biology, especially osteoclasts, in the pathogenesis of rheumatoid arthritis
The Th17 cell has become the most exiting field, not only in basic, but also clinical immunology. Th17 cells play an important role in bone cell biology. The anti-IL-17 antibody shows an effect on ankylosing spondylitis, non-radiographic axial spondylitis, psoriasis, and psoriatic arthritis. In therapy for rheumatoid arthritis (RA), anti-IL-17 antibody did not show enough effect in clinical trials. Recently, however, two meta-analysis reports demonstrated that the anti-IL-17 antibody is effective in ameliorating RA symptoms. Bi-specific antibodies, against both IL-17 and TNF-alpha, have shown effects on the activities of rheumatoid arthritis. In addition, the plasticity of Th17 is currently being investigated in basic and clinical immunology. The field of IL-17 and Th17 cells has moved very quickly, from bench to bedside or bedside to bench. Thus, please join us in presenting this Special Issue on the state-of-the-art research currently being performed worldwide, to investigate IL-17 and Th17, in order to help understand and treat various human autoimmune and inflammatory diseases.
Dr. Shigeru Kotake
Manuscript Submission Information
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- Th17 cell
- rheumatoid arthritis
- bispecific antibody