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The Role of Th17 Cells in the Pathogenesis of Behcet’s Disease

Institute of Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan
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Academic Editor: Emmanuel Andrès
J. Clin. Med. 2017, 6(7), 74; https://doi.org/10.3390/jcm6070074
Received: 27 April 2017 / Revised: 1 July 2017 / Accepted: 12 July 2017 / Published: 21 July 2017
(This article belongs to the Special Issue Th17 Cell in Autoimmune and Inflammatory Diseases)
Behcet’s disease (BD) is a polysymptomatic and recurrent systemic vasculitis with a chronic course and unknown cause. The pathogenesis of BD has not been fully elucidated; however, BD has been considered to be a typical Th1-mediated inflammatory disease, characterized by elevated levels of Th1 cytokines such as IFN-γ, IL-2, and TNF-α. Recently, some studies reported that Th17-associated cytokines were increased in BD; thus, Th17 cells and the IL17/IL23 pathway may play important roles in the pathogenesis of BD. In this chapter, we focus on the pathogenic role of Th17 cells in BD. View Full-Text
Keywords: Behcet’s disease; IL-17; Th17; regulatory T cells; Th1 Behcet’s disease; IL-17; Th17; regulatory T cells; Th1
MDPI and ACS Style

Nanke, Y.; Yago, T.; Kotake, S. The Role of Th17 Cells in the Pathogenesis of Behcet’s Disease. J. Clin. Med. 2017, 6, 74.

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