Next Article in Journal
Social Factors Determine the Emergency Medical Admission Workload
Next Article in Special Issue
T Helper 17 Cells in Primary Sjögren’s Syndrome
Previous Article in Journal
An Effective, Versatile, and Inexpensive Device for Oxygen Uptake Measurement
Review

Role of Gut Microbiota in Rheumatoid Arthritis

by 1,2,3 and 1,2,*
1
Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan
2
Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan
3
Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Shigeru Kotake
J. Clin. Med. 2017, 6(6), 60; https://doi.org/10.3390/jcm6060060
Received: 20 April 2017 / Revised: 1 June 2017 / Accepted: 6 June 2017 / Published: 9 June 2017
(This article belongs to the Special Issue Th17 Cell in Autoimmune and Inflammatory Diseases)
Rheumatoid arthritis (RA) is a systemic autoimmune disease, caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental agent affecting the development of RA. Here we review the evidence from animal and human studies that supports the role of the gut microbiota in RA. We and others have demonstrated that the abundance of Prevotella copri is increased in some early RA. We have also used gnotobiotic experiments to show that dysbiosis in RA patients contributed to the development of Th17 cell-dependent arthritis in intestinal microbiota-humanized SKG mice. On the other hand, Prevotella histicola from human gut microbiota suppressed the development of arthritis. In summary, Prevotella species are involved in the pathogenesis of arthritis. View Full-Text
Keywords: rheumatoid arthritis; microbiota; Prevotella copri; gut; Th17 cell rheumatoid arthritis; microbiota; Prevotella copri; gut; Th17 cell
Show Figures

Figure 1

MDPI and ACS Style

Maeda, Y.; Takeda, K. Role of Gut Microbiota in Rheumatoid Arthritis. J. Clin. Med. 2017, 6, 60. https://doi.org/10.3390/jcm6060060

AMA Style

Maeda Y, Takeda K. Role of Gut Microbiota in Rheumatoid Arthritis. Journal of Clinical Medicine. 2017; 6(6):60. https://doi.org/10.3390/jcm6060060

Chicago/Turabian Style

Maeda, Yuichi, and Kiyoshi Takeda. 2017. "Role of Gut Microbiota in Rheumatoid Arthritis" Journal of Clinical Medicine 6, no. 6: 60. https://doi.org/10.3390/jcm6060060

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop