Next Article in Journal / Special Issue
The Role of Th17 Cells in the Pathogenesis of Behcet’s Disease
Previous Article in Journal
Effects of Assault Type on Cognitive Behaviour Therapy for Coexisting Depression and Alcohol Misuse
Previous Article in Special Issue
Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessFeature PaperReview
J. Clin. Med. 2017, 6(7), 73;

Th17 in Animal Models of Rheumatoid Arthritis

Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Sakyoku Syogoin Kawaramachi 54, Kyoto 606-8507, Japan
Received: 29 April 2017 / Revised: 13 July 2017 / Accepted: 15 July 2017 / Published: 21 July 2017
(This article belongs to the Special Issue Th17 Cell in Autoimmune and Inflammatory Diseases)
PDF [529 KB, uploaded 21 July 2017]


IL-17-secreting helper CD4 T cells (Th17 cells) constitute a newly identified subset of helper CD4 T cells that play a key role in the development of rheumatoid arthritis (RA) in its animal models. Recently, several models of spontaneous RA, which elucidate the mechanism of RA onset, have been discovered. These animal models shed new light on the role of Th17 in the development of autoimmune arthritis. Th17 cells coordinate inflammation and promote joint destruction, acting on various cells, including neutrophils, macrophages, synovial fibroblasts, and osteoclasts. Regulatory T cells cannot control Th17 cells under conditions of inflammation. In this review, the pathogenic role of Th17 cells in arthritis development, which was revealed by the recent animal models of RA, is discussed. View Full-Text
Keywords: IL-17-secreting helper CD4 T cells (Th17 cells); animal models; rheumatoid arthritis; synovial fibroblasts; regulatory T cells IL-17-secreting helper CD4 T cells (Th17 cells); animal models; rheumatoid arthritis; synovial fibroblasts; regulatory T cells

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Hashimoto, M. Th17 in Animal Models of Rheumatoid Arthritis. J. Clin. Med. 2017, 6, 73.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top