Management of Acute Severe Colitis in the Era of Biologicals and Small Molecules
1
Division of Gastroenterology, McGill University Health Centre, Montreal, QC H3G 1A4, Canada
2
Department of Gastroenterology, Campbelltown Hospital, Sydney, NSW 2560, Australia
3
1st Department of Medicine, Semmelweis University, Budapest H1083, Hungary
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(12), 2169; https://doi.org/10.3390/jcm8122169
Received: 14 November 2019
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Revised: 2 December 2019
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Accepted: 6 December 2019
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Published: 8 December 2019
(This article belongs to the Special Issue Ulcerative Colitis: Current and Emerging Treatment Strategies)
Acute severe ulcerative colitis (ASUC) is a medical emergency which occurs in about 20%–30% of patients with ulcerative colitis during their lifetime, and does carry a mortality risk of 1%. The management of inflammatory bowel diseases has evolved with changes in objective patient monitoring, as well as the availability of new treatment options with the development of new biological and small molecules; however, data is limited regarding their use in the context of ASUC. This review aims to discuss the emerging data regarding biologicals and small molecules therapies in the context of ASUC.
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Keywords:
acute severe ulcerative colitis; infliximab; cyclosporine; tacrolimus; corticosteroids; surgical management
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Verdon, C.; Bessissow, T.; Lakatos, P.L. Management of Acute Severe Colitis in the Era of Biologicals and Small Molecules. J. Clin. Med. 2019, 8, 2169. https://doi.org/10.3390/jcm8122169
AMA Style
Verdon C, Bessissow T, Lakatos PL. Management of Acute Severe Colitis in the Era of Biologicals and Small Molecules. Journal of Clinical Medicine. 2019; 8(12):2169. https://doi.org/10.3390/jcm8122169
Chicago/Turabian StyleVerdon, Christine, Talat Bessissow, and Peter L. Lakatos. 2019. "Management of Acute Severe Colitis in the Era of Biologicals and Small Molecules" Journal of Clinical Medicine 8, no. 12: 2169. https://doi.org/10.3390/jcm8122169
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