History of Inflammatory Bowel Diseases
1
Gastroenterology and Clinical Immunology, Turin General Hospitals, 10100 Turin, Italy
2
Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy
3
Institute of Biostructures and Bioimaging (CNR) c/o Molecular Biotechnology Center, 10126 Turin, Italy
4
Department of Surgical Sciences, University of Turin, 10100 Turin, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(11), 1970; https://doi.org/10.3390/jcm8111970
Received: 7 September 2019 / Revised: 2 November 2019 / Accepted: 12 November 2019 / Published: 14 November 2019
(This article belongs to the Special Issue Ulcerative Colitis: Current and Emerging Treatment Strategies)
Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal mucosa and unknown etiology. In this review, we identified three main eras in the IBD history. Between the 19th and the 20th century, the primary task had been the definition of the diagnostic criteria in order to differentiate the new entity from intestinal tuberculosis. In the 20th century, an intense and prolific therapeutic research prevailed, culminating in the introduction of biological drugs in the clinical setting. Since the beginning of the 21st century, traditional definition criteria have been challenged by holistic criteria in an effort to seek a still unattained cure. Centuries of worldwide efforts on IBD etiology and therapy search have culminated in this novel strategy.
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Keywords:
ulcerative colitis; inflammatory bowel disease; therapy; inflammation; bowel; interactome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Actis, G.C.; Pellicano, R.; Fagoonee, S.; Ribaldone, D.G. History of Inflammatory Bowel Diseases. J. Clin. Med. 2019, 8, 1970. https://doi.org/10.3390/jcm8111970
AMA Style
Actis GC, Pellicano R, Fagoonee S, Ribaldone DG. History of Inflammatory Bowel Diseases. Journal of Clinical Medicine. 2019; 8(11):1970. https://doi.org/10.3390/jcm8111970
Chicago/Turabian StyleActis, Giovanni C.; Pellicano, Rinaldo; Fagoonee, Sharmila; Ribaldone, Davide G. 2019. "History of Inflammatory Bowel Diseases" J. Clin. Med. 8, no. 11: 1970. https://doi.org/10.3390/jcm8111970
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