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Open AccessReview

History of Inflammatory Bowel Diseases

Gastroenterology and Clinical Immunology, Turin General Hospitals, 10100 Turin, Italy
Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy
Institute of Biostructures and Bioimaging (CNR) c/o Molecular Biotechnology Center, 10126 Turin, Italy
Department of Surgical Sciences, University of Turin, 10100 Turin, Italy
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(11), 1970;
Received: 7 September 2019 / Revised: 2 November 2019 / Accepted: 12 November 2019 / Published: 14 November 2019
(This article belongs to the Special Issue Ulcerative Colitis: Current and Emerging Treatment Strategies)
Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal mucosa and unknown etiology. In this review, we identified three main eras in the IBD history. Between the 19th and the 20th century, the primary task had been the definition of the diagnostic criteria in order to differentiate the new entity from intestinal tuberculosis. In the 20th century, an intense and prolific therapeutic research prevailed, culminating in the introduction of biological drugs in the clinical setting. Since the beginning of the 21st century, traditional definition criteria have been challenged by holistic criteria in an effort to seek a still unattained cure. Centuries of worldwide efforts on IBD etiology and therapy search have culminated in this novel strategy. View Full-Text
Keywords: ulcerative colitis; inflammatory bowel disease; therapy; inflammation; bowel; interactome ulcerative colitis; inflammatory bowel disease; therapy; inflammation; bowel; interactome
MDPI and ACS Style

Actis, G.C.; Pellicano, R.; Fagoonee, S.; Ribaldone, D.G. History of Inflammatory Bowel Diseases. J. Clin. Med. 2019, 8, 1970.

AMA Style

Actis GC, Pellicano R, Fagoonee S, Ribaldone DG. History of Inflammatory Bowel Diseases. Journal of Clinical Medicine. 2019; 8(11):1970.

Chicago/Turabian Style

Actis, Giovanni C.; Pellicano, Rinaldo; Fagoonee, Sharmila; Ribaldone, Davide G. 2019. "History of Inflammatory Bowel Diseases" J. Clin. Med. 8, no. 11: 1970.

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