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Review

Uric Acid and Hypertension: Prognostic Role and Guide for Treatment

1
Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
2
IRCCS, Azienda Ospedaliero, Universitaria di Bologna, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(3), 448; https://doi.org/10.3390/jcm10030448
Received: 7 December 2020 / Revised: 19 January 2021 / Accepted: 21 January 2021 / Published: 24 January 2021
The relationship between serum uric acid (SUA) and hypertension has been a subject of increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several epidemiological studies have shown a strong association between high SUA levels and the presence or the development of hypertension. Genetic analyses have found that xanthine oxidoreductase (XOR) genetic polymorphisms are associated with hypertension. However, genetic studies on urate transporters and Mendelian randomization studies failed to demonstrate a causal relationship between SUA and hypertension. Results from clinical trials on the role of urate-lowering therapy in the management of patients with hypertension are not uniform. Our study sought to analyze the prognostic and therapeutic role of SUA in the hypertensive disease, from uric acid (UA) biology to clinical trials on urate-lowering therapies. View Full-Text
Keywords: uric acid; hypertension; cardiovascular risk; urate-lowering therapy; xanthine oxidase uric acid; hypertension; cardiovascular risk; urate-lowering therapy; xanthine oxidase
MDPI and ACS Style

Piani, F.; Cicero, A.F.G.; Borghi, C. Uric Acid and Hypertension: Prognostic Role and Guide for Treatment. J. Clin. Med. 2021, 10, 448. https://doi.org/10.3390/jcm10030448

AMA Style

Piani F, Cicero AFG, Borghi C. Uric Acid and Hypertension: Prognostic Role and Guide for Treatment. Journal of Clinical Medicine. 2021; 10(3):448. https://doi.org/10.3390/jcm10030448

Chicago/Turabian Style

Piani, Federica, Arrigo F.G. Cicero, and Claudio Borghi. 2021. "Uric Acid and Hypertension: Prognostic Role and Guide for Treatment" Journal of Clinical Medicine 10, no. 3: 448. https://doi.org/10.3390/jcm10030448

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