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Article

Calcium Channel Blockers Are Associated with Nocturia in Men Aged 40 Years or Older

1
Department of Urology, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan
2
Department of Cardiology, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Francesca Chiara Viazzi
J. Clin. Med. 2021, 10(8), 1603; https://doi.org/10.3390/jcm10081603
Received: 1 March 2021 / Revised: 24 March 2021 / Accepted: 31 March 2021 / Published: 9 April 2021
Background: The associations of nocturia with hypertension and anti-hypertensive agents (AHTs) remain to be validated. Methods: This cross-sectional study examined whether blood pressure and/or frequently used classes of AHTs had consistent associations with nocturia. Methods: A total of 418 male patients aged ≥ 40 years were retrospectively assessed in terms of the International Prostate Symptom Score (IPSS), prescription medications, and blood pressure. Nocturia was evaluated using item 7 of the IPSS, and two or more episodes of nocturia per night was considered to indicate clinically important nocturia. Results: Patients taking calcium channel blockers (CCBs), but not other AHTs, experienced more episodes of nocturia than patients not taking AHTs (1.77 ± 1.07, 1.90 ± 1.19, and 1.48 ± 0.98 in CCBs alone, CCBs + other AHTs, and other AHTs alone, vs. 1.35 ± 1.08 in not taking AHTs; p = 0.014, p < 0.0001, and p = 0.91, respectively), whereas there was no significant difference in the number of nocturia episodes between patients with elevated and normal blood pressure. In multivariate analysis, CCB (odds ratio (OR) = 2.68, p < 0.0001) and age (OR = 1.06, p < 0.0001) were independently associated with clinically important nocturia. Conclusion: CCB was associated with nocturia, while AHTs other than CCBs and elevated blood pressure were not. View Full-Text
Keywords: nocturia; calcium channel blocker; anti-hypertensive agents; hypertension; blood pressure nocturia; calcium channel blocker; anti-hypertensive agents; hypertension; blood pressure
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MDPI and ACS Style

Washino, S.; Ugata, Y.; Saito, K.; Miyagawa, T. Calcium Channel Blockers Are Associated with Nocturia in Men Aged 40 Years or Older. J. Clin. Med. 2021, 10, 1603. https://doi.org/10.3390/jcm10081603

AMA Style

Washino S, Ugata Y, Saito K, Miyagawa T. Calcium Channel Blockers Are Associated with Nocturia in Men Aged 40 Years or Older. Journal of Clinical Medicine. 2021; 10(8):1603. https://doi.org/10.3390/jcm10081603

Chicago/Turabian Style

Washino, Satoshi, Yusuke Ugata, Kimitoshi Saito, and Tomoaki Miyagawa. 2021. "Calcium Channel Blockers Are Associated with Nocturia in Men Aged 40 Years or Older" Journal of Clinical Medicine 10, no. 8: 1603. https://doi.org/10.3390/jcm10081603

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