The Perspective of Freeze-All in Assisted Reproductive Technologies

Dear Colleagues,

The prevalence of freeze-all policy (or elective embryo transfer) in reproductive medicine is rising globally. Its advantages are mainly shown in terms of avoiding the deleterious effects of ovarian stimulation on embryo–endometrium synchrony and the risk of ovarian hyperstimulation syndrome. Based on this strategy, novel protocols have been developed; these include progestin-primed ovarian stimulation (PPOS) and double ovarian stimulation, which provide more flexible approaches. However, there is still a lack of worldwide consensus on the pros and cons of freeze-all. Although a great deal of experience has been accumulated in clinical practice, evidence gaps persist at all points in translating the strategy to efficacious therapies. For instance, more research is needed to understand the molecular mechanism of vitrification, to confirm the efficacy of non-classical protocols of ovarian stimulation, to balance the costs and benefits in the field of health management, and to evaluate the long-term safety of vitrification for offspring. The scope of this Special Issue is to provide an overview of recent advances and prospective developments in the freeze-all field. Therefore, researchers in the field of reproductive medicine are encouraged to submit original articles or reviews to this Special Issue (case reports and short reviews are not accepted).

Prof. Dr. Yanping Kuang
Dr. Qiuju Chen
Guest Editors

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