Platelets and the Antiplatelet Drugs: From Bench to Bedside and Back

Dear Colleagues,

Circulating platelets, in particular those with hyperactivity, play an essential role in the initiation and progression of thrombotic vascular diseases, such as coronary artery disease and ischemic stroke. Thus, antiplatelet drugs are widely used for the prevention of all thrombosis-associated vascular diseases. On the one hand, the thorough dissection of the physiology and pathophysiology of platelets in their entire life cycle (including young reticulated immature platelets) provides potential therapeutic targets for the discovery and development of novel antiplatelet drugs, such as COX1 inhibitors, P2Y12 receptor antagonists, GP IIb/IIIa inhibitors or receptor blockers, PAR1 receptor blockers, and more. On the other hand, clinical research studies and evaluations of marketed antiplatelet drugs would help us better understand the nature of these drugs for optimal patient care and also for the further improvement of drug research and development. This Special Issue of the Journal of Clinical Medicine, titled "Platelets and the Antiplatelet Drugs: from bench to bedsite and back", will focus on recent advances in basic research and clinical studies of platelets and the antiplatelet drugs (marketed or in the pipeline), all of which lie in the scope of the above-designated title. Contributions on these and related topics are welcome, including original papers and review articles.

Prof. Dr. Hong-Guang Xie
Guest Editor

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