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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Machine Learning Applications in Bioinformatics and Biomedicine: 3rd Edition

edited by Hao Lv

submission deadline 30 Sep 2025 | Viewed by 46 | Submission Open

Keywords: genome; transcriptome; proteome; metabolome; drug target; machine learning; prediction of drug side effects; epigenetic marker discovery for diseases; molecular network marker; early screening of diseases

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanism and Breeding of Abiotic and Biotic Stress Tolerance in Crops

edited by

Waltram Ravelombola

submission deadline 30 Sep 2025 | Viewed by 46 | Submission Open

Keywords: crop production; abiotic stress; biotic stress; genetic mechanism; molecular markers; crop variety improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Molecular Advances in Prostate Cancer

edited by Rejane Maira Góes

submission deadline 30 Sep 2025 | Viewed by 46 | Submission Open

Keywords: prostate cancer; androgen signaling; metabolic reprogramming; tumor microenvironment; inflammation; immunotherapy; chemoprotection; phytotherapy

(This special issue belongs to the Section Molecular Oncology)

Cellular and Molecular Biology of Cardiac Hypertrophy and Heart Failure: Pathogenesis, Diagnostics and Treatment—2nd Edition

edited by

Morris Karmazyn

submission deadline 30 Sep 2025 | Viewed by 45 | Submission Open

Keywords: cardiac hypertrophy; myocardial remodelling; heart failure; cellular mechanisms; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lung Cancer: From Molecular Mechanisms to Novel Therapeutics: 2nd Edition

edited by

Mariacarmela Santarpia

and

Giulia Pasello

submission deadline 30 Sep 2025 | Viewed by 45 | Submission Open

Keywords: lung cancer; oncogene; targeted therapy; immunotherapy; predictive biomarkers; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Rare Diseases: From Pathogenesis to Innovative Therapies

edited by Grażyna Gromadzka

submission deadline 30 Sep 2025 | Viewed by 45 | Submission Open

Keywords: rare diseases; orphan disorders; orphan drugs; gene therapy; precision medicine; biomarkers in rare diseases; gene therapy; CRISPR therapy; CRISPR-mediated DNA editing; CRISPR technology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Therapeutic Targets in the Evolving Landscape of Cancer Immunotherapy 2nd Edition

edited by

Domenico Galati

submission deadline 30 Sep 2025 | Viewed by 44 | Submission Open

Keywords: immune checkpoints; targeted therapies; tumor microenvironment; cancer immunology; precision medicine; cell-based cancer therapy

(This special issue belongs to the Section Molecular Immunology)

Role of Mutations and Polymorphisms in Various Diseases: 2nd Edition

edited by

Anna Cieslinska

submission deadline 30 Sep 2025 | Viewed by 44 | Submission Open

Keywords: nutrigenomics; polymorphism; SNPs; mutations; predisposition; correlation; diversity; deletion; insertion

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Therapies, Pathogenetic and Inflammatory Mechanisms in Thrombosis

edited by

Matteo Becatti

submission deadline 30 Sep 2025 | Viewed by 44 | Submission Open

Keywords: thromboinflammation; endothelial dysfunction; antithrombotic therapies; oxidative stress; thrombosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Insights into Antibacterial Material

edited by Rahela Carpa

submission deadline 30 Sep 2025 | Viewed by 44 | Submission Open

Keywords: antimicrobial resistance; nanoparticles; biopolymers; antimicrobial peptides; antimicrobial materials

(This special issue belongs to the Section Materials Science)

Dialogue Between Inflammation and Immunity: From Mechanism to Therapy

edited by

Nikolina Mihaylova

submission deadline 30 Sep 2025 | Viewed by 43 | Submission Open

Keywords: inflammation; immune activation; immunomodulation; tolerance; immunotherapy; autoimmune diseases; cancer

(This special issue belongs to the Section Molecular Immunology)

Relationship Between Plant Microbiome and Immunity

edited by

Sergio Molinari

submission deadline 30 Sep 2025 | Viewed by 43 | Submission Open

Keywords: microbiome; plant immune system; rhizosphere of plant roots; microbe-associated molecular patterns (MAMPs)

(This special issue belongs to the Section Molecular Plant Sciences)

Bioactive Compounds in Bee Products: Chemistry, Mechanisms of Action and Nutritional Applications

edited by

Jarosław Widelski

and

Ioanna Chinou

submission deadline 30 Sep 2025 | Viewed by 43 | Submission Open

Keywords: honey; propolis; royal jelly; polyphenols; nutritional properties; bioactivity; analytical and isolation methods; bee pollen

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Roles of Non-Coding RNAs in Cancer

edited by Amit K. Mitra

submission deadline 30 Sep 2025 | Viewed by 43 | Submission Open

Keywords: lncRNA; miRNA; cancer; genomics; targeted therapy; biomarkers; drug resistance

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Insights in the Mechanism of Obstetrical Complications: Prevention, Diagnosis, Monitoring, Treatment

edited by

Lucia Maria Procopciuc

and

Roxana Liana Lucaciu

submission deadline 30 Sep 2025 | Viewed by 42 | Submission Open

Keywords: high blood pressure; gestational diabetes; infections; preeclampsia; eclampsia; preterm labor; depresion; anxiety; pregnancy loss/miscarriage; stillbirth; premature membrane rupture; vaginal bleeding; placenta previa; anemia; intrauterine growth restriction; maternal risk factors; fetal risk factors; endothelial dysfunction; angiogenesis; oxidative stress; hormonal modifications; dyslipidemia; biochemical; genetic; epigenetic determinations; computational analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Micronutrients in Cancer Prevention

edited by Jacek Baj

submission deadline 30 Sep 2025 | Viewed by 42 | Submission Open

Keywords: micronutrient; metallomics; metallomic analysis; nutrient; ICP-MS; ICP-OES; prevention; carcinogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Biology of Periodontal Disease and Periodontal Pathogens

edited by Yago Leira and

João Botelho

submission deadline 30 Sep 2025 | Viewed by 42 | Submission Open

Keywords: periodontitis; general medicine; inflammation; bacteraemia; education

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and Insights into COVID-19: Third Edition

edited by

Manuela Rizzi

and

Pier Paolo Sainaghi

submission deadline 30 Sep 2025 | Viewed by 41 | Submission Open

Keywords: SARS-CoV-2; COVID-19; prognostic and diagnostic biomarkers; molecular mechanism of infection; molecular pathophysiology; immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanomedicine: Application of Nanostructured Biomaterials in the Biomedical Field

edited by

Yaser Dahman

submission deadline 30 Sep 2025 | Viewed by 41 | Submission Open

Keywords: nanomedicine; nanostructured biomaterials; targeted drug delivery; tissue regeneration; biosensing

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Pharmacology and Interventions in Cardiovascular Disease: 2nd Edition

edited by

Magdalena Zabielska-Kaczorowska

submission deadline 30 Sep 2025 | Viewed by 41 | Submission Open

Keywords: cardiovascular pharmacology; cardiovascular interventions; cardioprotection; myocardial ischemia and infarction; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Approaches to Asthma Management

edited by

Diego Bagnasco

and

Corrado Pelaia

submission deadline 30 Sep 2025 | Viewed by 41 | Submission Open

Keywords: severe asthma; type 2 and non-type 2 inflammation; antibodies; comorbidities; treatable traits

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Aging and Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics—2nd Edition

edited by Lilach Soreq

submission deadline 30 Sep 2025 | Viewed by 41 | Submission Open

Keywords: aging; Alzheimer’ s disease; bioinformatics; RNA-seq; Parkinson’ s disease

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Detection and Analysis of Microbial Pathogens

edited by Ignacio Garcia

submission deadline 30 Sep 2025 | Viewed by 41 | Submission Open

Keywords: molecular diagnostics; antimicrobial resistance; emerging pathogens; bioinformatics; metagenomics; clinical microbiology; environmental microbiology; surveillance; outbreak detection

(This special issue belongs to the Section Molecular Microbiology)

Application of NMR Spectroscopy in Biomolecules: 2nd Edition

edited by

Luigi Russo

submission deadline 30 Sep 2025 | Viewed by 40 | Submission Open

Keywords: advanced solution and solid state biomolecular NMR techniques; structure and dynamics of biomolecules: proteins; peptides; and nucleic acids; paramagnetic NMR; in/on cell-NMR; protein– ligand; protein– DNA; protein– RNA interaction; protein folding and misfolding; structure-based drug screening; fragment-based drug screening; computational NMR methods; sample preparation and isotope labeling strategies; NMR metabolomics and foodomics; membrane proteins and lipids; natural-abundance NMR spectroscopy; pharmaceutical NMR applications; disordered proteins and peptides; drugs development; metal-binding biomolecules; hyperpolized NMR techniques; 19F NMR spectroscopy; NMR techniques for the analysis of complex mixtures; integrated NMR-based methodologies

(This special issue belongs to the Section Molecular Biophysics)

Research on Plant Genomics and Breeding: 3rd Edition

edited by

Zhiyong Li

Jian Zhang

and

Dawei Xue

submission deadline 30 Sep 2025 | Viewed by 39 | Submission Open

Keywords: gene cloning and function; genetic engineering; molecular genetics; genome editing; regulatory mechanisms; germplasm enhancement; molecular breeding and marker-assisted selection

(This special issue belongs to the Section Molecular Plant Sciences)

Bioplastic-Related Toxicity in Humans: New Insights and Molecular Mechanisms

edited by

Antonietta Santoro

and

Marta Anna Szychlinska

submission deadline 30 Sep 2025 | Viewed by 39 | Submission Open

Keywords: bioplastics and biopolymers -related toxicity; microplastics and nanoplastics accumulation/degradation in mammals; cell cultures; human health; in vivo models; epigenetics effects; endocrine disruptor properties of bioplastics; bioplastics and inflammation; bioplastics in neurodegeneration and neuroinflammation; reproduction; cell metabolism; immunomodulation

(This special issue belongs to the Section Molecular Toxicology)

Surfactants: Design, Synthesis and Properties

edited by

Joanna Krawczyk

submission deadline 30 Sep 2025 | Viewed by 39 | Submission Open

Keywords: design and synthesis of surfactants; adsorption and aggregation properties of surfactants; behavior of surfactants at different interfaces; application of biosurfactants and specialist surfactants (industry; agriculture; medicine; pharmacy)

(This special issue belongs to the Section Materials Science)

Regulatory Mechanisms in Kidney Development and Function

edited by Gary F. Gerlach

submission deadline 30 Sep 2025 | Viewed by 39 | Submission Open

Keywords: drosophila nephrocyte; zebrafish pronephros; mesonephros; murine nephrogenesis; slit diaphragm; podocytes; junctions; tubule; mesenchymal-to-epithelia transition (MET); epithelial-to-mesenchymal transition (EMT); tubule segmentation; transcription factors; signaling pathways; foot processes; cytoskeleton; brush boarder; intercalated cells; renin angiotensin; diabetic kidney disease; podocytopathies; FSGS; minimal change disease; IgAN

(This special issue belongs to the Section Molecular Biology)

Hormone Receptors and Signaling in Breast Cancer, 2nd Edition

edited by

Farzad Pakdel

submission deadline 30 Sep 2025 | Viewed by 39 | Submission Open

Keywords: breast cancer; hormone receptor; growth factor receptor; estrogen receptor; endocrine therapies; PI3K; AKT; mTOR; signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Novel Therapeutic Strategies for Cancers

edited by

Emanuela Grassilli

and

Maria Grazia Cerrito

submission deadline 30 Sep 2025 | Viewed by 39 | Submission Open

Keywords: precision medicine; molecular targeted therapies; kinase inhibitors; PROTAC; CAR-T cell therapy; tumor microenvironment; host microbiota; resistance mechanisms; biomarkers; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Drug Repurposing: Emerging Approaches to Drug Discovery (2nd Edition)

edited by

Sona Vasudevan

submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open

Keywords: repurposed drugs; network medicine; systems medicine; drug design; therapeutic strategies; drug repurposing in the era of artificial intelligence; drug repositioning; machine learning

(This special issue belongs to the Section Molecular Pharmacology)

Eco-Conscious Therapeutics: Molecular Foundations and Future Directions in Green Medicine

edited by

Adi Lahat

and

Kassem Sharif

submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open

Keywords: green medicine; molecular therapeutics; sustainable healthcare; biomarker profiling; predictive toxicology; eco-friendly drug design; environmental impact; biodegradable materials

(This special issue belongs to the Section Molecular Toxicology)

Advances in Plant Biotechnology: From Pathogen Diagnostics to Disease Management

edited by

Abdul Kader Jailani Amirudeen

submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open

Keywords: plant pathogens; diagnostic; isothermal; biosensor; RNAi; CRISPRi; QTL mapping; GWAS; MAS or MABC

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Microbiology in the Omics Era: Genomics, Metagenomics and Computational Insights

edited by

Fei Liu

submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open

Keywords: microbial genomics; metagenomics; computational biology; antimicrobial resistance; host– microbe interactions; multi-omics integration; bioinformatics tools; machine learning in microbiology

(This special issue belongs to the Section Molecular Microbiology)

Advances in Epigenetics of Mental Disorders

edited by

Claudio Brasso

submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open

Keywords: mental disorders; epigenetic; epigenomic; gene– environment interactions

(This special issue belongs to the Section Molecular Neurobiology)

Research on System Biology Methods and Tools for Integrating Omics Data

edited by Yuanyan Xiong

submission deadline 30 Sep 2025 | Viewed by 37 | Submission Open

Keywords: systems biology; multi-omics integration; network analysis; computational biology; bioinformatics tools; machine learning; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Plant Senescence Under Environmental Stresses

edited by

Agnieszka Ostrowska

submission deadline 30 Sep 2025 | Viewed by 37 | Submission Open

Keywords: plant senescence; environmental stresses; phytohormones

(This special issue belongs to the Section Molecular Plant Sciences)

Pesticide Exposure and Toxicity Research: Impacts on Endocrine and Nervous System Pathophysiology

edited by

Jorgelina Varayoud

submission deadline 30 Sep 2025 | Viewed by 36 | Submission Open

Keywords: pesticide exposure; neurotoxicity; endocrine disruption; risk assessment; toxicological mechanisms; human health effects; biomonitoring; animal models

(This special issue belongs to the Section Molecular Toxicology)

Bone Microenvironment and Bone Metastasis

edited by

Cristina Sanchez de Diego

submission deadline 30 Sep 2025 | Viewed by 35 | Submission Open

Keywords: bone metastasis; tumor– bone interaction; bone microenvironment; osteoclastogenesis; osteoblast signaling; bone remodeling; dormancy; immune evasion; extracellular matrix

(This special issue belongs to the Section Molecular Oncology)

Plant Breeding Strategies: Employment of Plant Adaptation Mechanisms to Biotic and Abiotic Stresses

edited by

Vidmantas Bendokas

submission deadline 30 Sep 2025 | Viewed by 34 | Submission Open

Keywords: marker-assisted selection; molecular breeding; whole-transcriptome analysis; RNA sequencing; DNA sequencing; plant stress response

(This special issue belongs to the Section Molecular Plant Sciences)

RNA in Human Diseases: Challenges and Opportunities: 2nd Edition

edited by

Nicoletta Potenza

submission deadline 30 Sep 2025 | Viewed by 34 | Submission Open

Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification

(This special issue belongs to the Section Molecular Biology)

Mitochondrial Functions and Dynamics

edited by

Raffaella Isola

submission deadline 30 Sep 2025 | Viewed by 34 | Submission Open

Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro; cellular; and animal models; myopathies; mitochondria and immune system

(This special issue belongs to the Section Molecular Biology)

The Role of Extracellular Vesicles in Disease and Therapeutic Applications

edited by Sunyoung Park

submission deadline 30 Sep 2025 | Viewed by 34 | Submission Open

Keywords: extracellular vesicles (EVs); disease biomarkers; EV-based therapeutics; cancer diagnosis; drug delivery; immune modulation; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies

edited by Noah R. Johnson and

Chih Hung Lo

submission deadline 30 Sep 2025 | Viewed by 33 | Submission Open

Keywords: intrinsically disordered proteins; apolipoproteins; neuroinflammation and neuroimmune; autolysosomal and mitochondrial functions; lipid metabolism; blood-brain barrier; biosensors; nanomedicine; high-throughput screening; therapeutic discovery

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Immunosuppressive Therapy

edited by

Marta Grabowska

submission deadline 30 Sep 2025 | Viewed by 33 | Submission Open

Keywords: immunosuppressive drugs; calcineurin inhibitors; corticosteroids; inhibitors of purine synthesis; mammalian target of rapamycin inhibitors; biological treatment; cell-based therapies; biomarkers; genetic profiling

(This special issue belongs to the Section Molecular Immunology)

Advances in Surfactant Systems: Thermodynamics, Molecular Interactions, and Applications

edited by

Mihalj Poša

submission deadline 30 Sep 2025 | Viewed by 33 | Submission Open

Keywords: micelles; mixed micelles; thermodynamic functions of micellization; micellar solubilization; enthalpy– entropy compensation; boundary surface; Langmuir isotherm; theoretical models

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Probiotics and Prebiotics in Gut Health and Disease

edited by

Hikmate Abriouel

submission deadline 30 Sep 2025 | Viewed by 32 | Submission Open

Keywords: probiotics; prebiotics; gut microbiota; intestinal health; dysbiosis; host– microbe interactions; omics; gut– brain axis

(This special issue belongs to the Section Molecular Microbiology)

Genetic, Functional and Therapeutic Aspects of Procoagulant and Anticoagulant Factors (Third Edition)

edited by

Rima Dardik

and

Tami Livnat

submission deadline 30 Sep 2025 | Viewed by 32 | Submission Open

Keywords: procoagulant factors; anticoagulant factors; hemostasis; inflammation; genetics; therapeutics; cell signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

3D Cell and Tissue Culture Systems: Benefits to Research and Disease Diagnostics

edited by

Thomas J. Goodwin

submission deadline 30 Sep 2025 | Viewed by 32 | Submission Open

Keywords: 3D physiological relevance vs. 2D biology; 3D research; and diagnostic systems; evolving 3D “ omics” applications; research and clinical medicine; drug applications; toxicity evaluations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroendocrine Integration of Stress and Reproduction

edited by Maria Bernardete Cordeiro De Sousa

submission deadline 30 Sep 2025 | Viewed by 32 | Submission Open

Keywords: HPA axis; HPG axis; stress and reproduction; neuroendocrine regulation; cortisol and fertility; neuropeptides; epigenetics; reproductive dysfunction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Displaying special issue 2551-2600 on page 52 of 69.

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