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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Interactions Between Microalgae and Other Microorganisms
edited by Mohd Effendy Abd Wahid and
submission deadline 28 Feb 2027 | Viewed by 61 | Submission Open
Keywords: microalgae; phycosphere; algae–bacteria consortia; aquaculture biotechnology; microbial interactions
(This special issue belongs to the Section Molecular Microbiology)
Nano-Pharmaceutical Modelling and Nano-Drug Delivery: Complexation, Interaction Energies, and Predictive Design submission deadline 28 Feb 2027 | Viewed by 61 | Submission Open
Keywords: nano-drug delivery; nanocarriers; molecular modelling; drug–carrier complexation; interaction energies; binding affinity; host–guest inclusion complexes; pharmaceutical cocrystals; molecular dynamics simulation; machine learning; predictive formulation design
(This special issue belongs to the Section Molecular Nanoscience)
Applications of Electrochemistry in Medicine and Biotechnology
edited by Michael Klink
submission deadline 28 Feb 2027 | Viewed by 60 | Submission Open
Keywords: electrochemical biosensors; bioelectronics; biomaterials; corrosion inhibition; drug delivery systems; point-of-care diagnostics; implantable devices; bioelectrochemistry; molecular diagnostics; tissue engineering; wearable sensors; organ-on-chip; electrochemical impedance spectroscopy; biomedical applications; biodevices
(This special issue belongs to the Section Biochemistry)
Molecular Pathology and Emerging Therapies for Connective Tissue Diseases
edited by Joanna Kosałka-Węgiel and
submission deadline 28 Feb 2027 | Viewed by 60 | Submission Open
Keywords: systemic lupus erythematosus; systemic sclerosis; dermatomyositis; Sjogren disease; polymyositis; organ damage; pathogenesis; biomarkers; multi-omics; genomic; transcriptomic; metabolomic; treatments; therapeutic
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metabolic Programming: Control of Gene Expression in Health and Disease
edited by
submission deadline 28 Feb 2027 | Viewed by 59 | Submission Open
Keywords: metabolic programming; gene regulation; immunometabolism; oncometabolism; acetyl-CoA; epigenetics; transcription; NAD; one-carbon metabolism; metabolic biosensors
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Ambient Environmental Exposures and Chronic Obstructive Pulmonary Disease (COPD)
edited by
submission deadline 28 Feb 2027 | Viewed by 58 | Submission Open
Keywords: COPD; ambient air pollution; particulate matter; oxidative stress; airway inflammation; environmental toxicology; pulmonary biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immunology and Major Histocompatibility Complex (MHC) in Birds
edited by Antonio Arnaiz-Villena
submission deadline 28 Feb 2027 | Viewed by 58 | Submission Open
Keywords: birds; conservation; MHC; immunity; evolution; genetics; taxonomy
(This special issue belongs to the Section Molecular Immunology)
Inflammation-Driven Cellular Plasticity and Crosstalk in the Tumor Microenvironment
edited by Yasemin Basbinar
submission deadline 28 Feb 2027 | Viewed by 57 | Submission Open
Keywords: inflammatory tumor microenvironment; tumor immunology; cancer metastasis; tumor–immune–stromal interactions; single-cell and spatial omics; cancer cell plasticity; biomarkers; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Nanostructure-Based Biomaterials and Cell Therapies in Regenerative Medicine
edited by
submission deadline 28 Feb 2027 | Viewed by 54 | Submission Open
Keywords: regenerative medicine; nanostructure-based biomaterials; cell therapies; tissue engineering; stem cells; extracellular vesicles; nanomedicine; cell sheets; 3D bioprinting; drug delivery systems
(This special issue belongs to the Section Molecular Nanoscience)
Advances in Oral Microbiome and Inflammation
edited by David J. Vigerust
submission deadline 28 Feb 2027 | Viewed by 54 | Submission Open
Keywords: oral microbiome; oral dysbiosis; periodontal inflammation; host–microbe interactions; inflammatory biomarkers; periodontal disease; oral–systemic health; precision diagnostics
(This special issue belongs to the Section Molecular Microbiology)
RNA Regulation and Satellite Cell-Opathies: Molecular Pathogenesis and Therapeutic Frontiers in Neuromuscular Diseases submission deadline 28 Feb 2027 | Viewed by 52 | Submission Open
Keywords: satellite cells; neuromuscular disorders; alternative splicing; satellite cell-opathies; RNA-binding proteins; RNA therapeutics; molecular pathogenesis; myogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Translational Research and Therapeutic Strategies for Peritoneal Malignancies
edited by
submission deadline 28 Feb 2027 | Viewed by 52 | Submission Open
Keywords: peritoneal metastases; surgical oncology; cytoreductive surgery; HIPEC; PIPAC; intraperitoneal therapy; translational research; precision oncology; drug delivery; cancer treatment
(This special issue belongs to the Section Molecular Oncology)
Extracellular Vesicle-Mediated Communication in Tumor Progression and Metastasis
edited by Sze Keong Tey
submission deadline 28 Feb 2027 | Viewed by 52 | Submission Open
Keywords: extracellular vesicles; exosomes; tumor progression; cancer metastasis
(This special issue belongs to the Section Molecular Oncology)
Epithelial–Mesenchymal Transition (EMT) in Pathophysiology and Disease submission deadline 28 Feb 2027 | Viewed by 51 | Submission Open
Keywords: epithelial-mesenchymal transition; cell plasticity; mechanotransduction; metabolic reprogramming; phenotypic switching; mechanometabolism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Evolution in Upper Aerodigestive Tract Tumors: From Carcinogenesis to Precision Oncology
edited by and Pedro Nicolau Neto
submission deadline 28 Feb 2027 | Viewed by 51 | Submission Open
Keywords: upper aerodigestive tract carcinogenesis; molecular alterations in upper aerodigestive tract tumors; cancer prevention and early diagnosis; molecular profiling and biomarkers; tumor microenvironment and metastasis; genomic and epigenetic alterations; molecular mechanisms of tumor progression; therapeutic resistance; targeted therapy and immunotherapy; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Natural Bioactives: Neural, Metabolic, and Anti-Inflammatory Functions
edited by
submission deadline 28 Feb 2027 | Viewed by 51 | Submission Open
Keywords: natural bioactives; phytochemicals; polyphenols; neuroprotection; metabolism; inflammation; oxidative stress; mitochondria; autophagy; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Interactions in Drug Delivery: From Design to Therapeutic Outcomes
edited by Wenhao Wang
submission deadline 28 Feb 2027 | Viewed by 50 | Submission Open
Keywords: molecular interactions; drug delivery; self-assembly carrier; protein corona; nano–bio interface; targeted delivery; in vivo fate; pharmacokinetics
(This special issue belongs to the Section Molecular Pharmacology)
Next-Generation and Third-Generation Sequencing in Life Sciences: Methods and Applications submission deadline 28 Feb 2027 | Viewed by 50 | Submission Open
Keywords: next-generation sequencing; third-generation sequencing; NGS; long-read sequencing; short-read sequencing; whole-genome sequencing; transcriptomics; RNA sequencing; metagenomics; metatranscriptomics; microbiome; genome assembly; bioinformatics; sequencing technologies; multi-omics; genomic analysis; molecular biology; life sciences
(This special issue belongs to the Section Molecular Informatics)
Hypoxia: Molecular Mechanism and Health Effects, 2nd Edition submission deadline 28 Feb 2027 | Viewed by 49 | Submission Open
Keywords: hypoxia; inflammation; oxidative stress; metabolic conditions; hypoxia-inducible factors (HIFs); oxidative stress; mitochondrial dysfunction; angiogenesis; metabolic reprogramming; apoptosis
(This special issue belongs to the Section Molecular Biology)
Hereditary Cancer Genomics in the Era of Next-Generation Sequencing: From Variant Discovery to Precision Prevention
edited by and Rosa Maria Alvarez-Gomez
submission deadline 28 Feb 2027 | Viewed by 48 | Submission Open
Keywords: hereditary cancer; cancer predisposition; germline variants; pathogenic variants; next-generation sequencing; multigene panel testing; variant interpretation; cancer genomics; precision oncology; genetic testing; hereditary cancer syndromes; molecular diagnostics; germline variants; molecular oncology; precision prevention; translational genomics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms and Therapies of Myeloid Leukaemia, 3rd Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 48 | Submission Open
Keywords: acute leukemia; myeloid leukemia; pediatric leukemia; adult leukemia; targeted therapy; antigens
(This special issue belongs to the Section Molecular Oncology)
Current Research on Polyphenol and Neurodegenerative Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 48 | Submission Open
Keywords: polyphenols; neurodegenerative disorders; Alzheimer's disease; Parkinson's disease; neuroprotection; oxidative stress; neuroinflammation; natural products; mitochondrial dysfunction; functional foods
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Drug Delivery Systems of Curcumin and Its Therapeutic Applications
edited by and
submission deadline 28 Feb 2027 | Viewed by 47 | Submission Open
Keywords: bioavailability; curcumin; drug delivery; nanocarriers; nanomedicine; nanoparticles; pharmacokinetics
(This special issue belongs to the Section Molecular Pharmacology)
PI3K/AKT/mTOR: The Central Processor in Cancer
edited by Marcia Bellon
submission deadline 28 Feb 2027 | Viewed by 46 | Submission Open
Keywords: mTOR; PI3K; AKT; drug targeting; therapeutic resistance; oncology metabolism; cell signaling
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanism and Therapy of Respiratory Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 45 | Submission Open
Keywords: respiratory diseases; molecular mechanisms; precision medicine; airway inflammation; pulmonary fibrosis; COPD; asthma; cystic fibrosis; biomarkers; drug discovery; organoids; therapeutic development
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Biomaterials and Formulations in Tissue Regeneration
edited by Giulio Ghersi and Francesco Carfì Pavia
submission deadline 28 Feb 2027 | Viewed by 45 | Submission Open
Keywords: extracellular matrix; fibroblast; microvascular fragments; collagen; growth factors; scaffolds; hydrogels; composite materials; additive manufacturing; green molecules
(This special issue belongs to the Section Materials Science)
Recent Advances in Conducting Polymer Hydrogels
edited by
submission deadline 28 Feb 2027 | Viewed by 45 | Submission Open
Keywords: conductive hydrogels; stimuli-responsive hydrogels; biosensors; tissue engineering; drug delivery; biocompatibility
(This special issue belongs to the Section Materials Science)
Oral‑Gut Microbiota Crosstalk: Molecular Mechanisms, Stress Responses and Systemic Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 44 | Submission Open
Keywords: oral-gut axis; oral microbiota; oral biofilm; periodontal pathogens
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research Progress in Malignant Hyperthermia Susceptibility
edited by Helga Cristina Almeida Da Silva
submission deadline 28 Feb 2027 | Viewed by 44 | Submission Open
Keywords: anaesthesia; calcium signalling; human genetics; malignant hyperthermia; muscle disorders; ryanodine receptor
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Cellular Immunotherapies
edited by Maria Elena Candela
submission deadline 28 Feb 2027 | Viewed by 43 | Submission Open
Keywords: cellular immunotherapy; adoptive cell therapy; engineered immune cells; CAR-T cells; natural killer cells; macrophage therapy; immune regulation; gene editing; regenerative medicine; clinical translation
(This special issue belongs to the Section Molecular Immunology)
Recent Advances in Nanoelectronics and Associated Applications submission deadline 28 Feb 2027 | Viewed by 42 | Submission Open
Keywords: nanoelectronics; low-dimensional materials; semiconductor devices; neuromorphic; quantum; nanosensors; nanophotonics; energy-efficient circuits; healthcare; environmental monitoring; energy systems; next-generation computing
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Editorial Board Members’ Collection Series in "Biomolecular Structure and Interactions"
edited by
submission deadline 28 Feb 2027 | Viewed by 42 | Submission Open
Keywords: protein–protein interactions; molecular dynamics simulations; cryo-electron microscopy; binding free energy; intrinsically disordered proteins
(This special issue belongs to the Section Molecular Biophysics)
Stem Cells for Neurological Disorders: Disease Modeling and Therapy
edited by Leonardo Romorini
submission deadline 28 Feb 2027 | Viewed by 40 | Submission Open
Keywords: stem cells; neurological disorders; regenerative medicine; disease modeling; induced pluripotent stem cells; neural stem cells; brain organoids; cell therapy; neurodegeneration; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Pathways Driving Autoimmune Inflammation
edited by
submission deadline 28 Feb 2027 | Viewed by 38 | Submission Open
Keywords: autophagy; autoantibodies; epitopes; autoantigens; mTor; post-translational modification of proteins; citrullination; carbamylation; acetylation; antiphospholipid antibody syndrome; rheumatoid arthritis
(This special issue belongs to the Section Molecular Biology)
Molecular Biomarkers in Cancers: Advances and Challenges, 3rd Edition submission deadline 28 Feb 2027 | Viewed by 37 | Submission Open
Keywords: cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Functional Luminescent Materials
edited by Arkadiusz Matwijczuk
submission deadline 28 Feb 2027 | Viewed by 36 | Submission Open
Keywords: room-temperature phosphorescence (RTP); ultralong RTP and afterglow; delayed fluorescence and long-lived luminescence; triplet-state photophysics; intersystem crossing (ISC) and reverse intersystem crossing (RISC); polymer matrices and polymer-based luminescent materials; sustainable and bio-derived luminescent materials; molecular rigidification and restriction of intramolecular motion (RIM); aggregation-induced emission (AIE) and aggregation-enhanced emission (AEE); molecular aggregation and self-assembly; excited-state proton transfer (ESIPT/ESPT); charge-transfer processes (ICT, TICT); excited-state dynamics; molecular packing and intermolecular interactions; crystalline, amorphous, supramolecular, and hybrid luminescent materials; fluorescence and phosphorescence spectroscopy; time-resolved and time-gated spectroscopy; DFT and TD-DFT calculations; optical sensing and time-gated bioimaging; anti-counterfeiting and information encryption; functional photonic and optoelectronic materials
(This special issue belongs to the Section Materials Science)
Neuroinflammation: Molecular Mechanisms and Therapeutic Targets
edited by Rajkumar Vutukuri and
submission deadline 28 Feb 2027 | Viewed by 34 | Submission Open
Keywords: neuroinflammation; neurodegenerative diseases; glial activation; therapeutic targets; blood–brain barrier; neuroimmune signaling
(This special issue belongs to the Section Molecular Neurobiology)
Advances and Perspectives in Mass Spectrometry for Biomaterial Analysis
edited by
submission deadline 1 Mar 2027 | Viewed by 382 | Submission Open
Keywords: mass spectrometry; biopolymers; biomaterials; compositional and structural analysis; surface and interface analysis; biofunctionalization; industrial and clinical applications
(This special issue belongs to the Section Materials Science)
Molecular Breeding for Abiotic Stress Tolerance in Crops (Second Edition)
edited by
submission deadline 20 Mar 2027 | 9 articles | Viewed by 16452 | Submission Open
Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes
(This special issue belongs to the Section Molecular Plant Sciences)
Intestinal Diseases and Gut Microbiota
edited by
submission deadline 20 Mar 2027 | 2 articles | Viewed by 5638 | Submission Open
Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Conventional Tree Breeding: Integrating Phenotypic Selection, Genetic Gain, and Sustainable Forest Management
edited by
submission deadline 20 Mar 2027 | 1 articles | Viewed by 3978 | Submission Open
Keywords: forest trees; genetic breeding; conventional tree breeding; forest management; forest tree varieties; modern molecular technology; genetic engineering
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Plant Protein and Enzyme Inhibitors
edited by Yan Zhang
submission deadline 20 Mar 2027 | Viewed by 653 | Submission Open
Keywords: plant proteins; active substances; bioactive compounds; enzyme inhibitors
(This special issue belongs to the Section Molecular Plant Sciences)
Application of Molecular Technology to Dental Treatment
edited by
submission deadline 20 Mar 2027 | Viewed by 364 | Submission Open
Keywords: biotechnology; implant material; titanium; zirconia; PEEK; in vitro; in vivo
(This special issue belongs to the Section Materials Science)
Hepatopancreatic and Intestine Diseases: From Molecular Basis to Therapy—Mitochondrial Insights submission deadline 20 Mar 2027 | Viewed by 242 | Submission Open
Keywords: hepatopancreatic diseases; intestine diseases; molecular basis therapy; pathogenesis; molecular pathways; pharmacological interventions; surgical techniques; immunotherapies; regenerative medicine approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Marine Toxins: Molecular and Biochemical Mechanisms of Marine and Freshwater Algal Toxins
edited by and Allisson Astuya-Villalón
submission deadline 20 Mar 2027 | Viewed by 96 | Submission Open
Keywords: harmful algal blooms (HABs); molecular toxicology; marine and freshwater toxins; cytotoxicity mechanisms; toxin–cell interactions; biochemical and structural biology; mechanistic omics; ichthyotoxicity; signal transduction; structure–activity relationships
(This special issue belongs to the Section Molecular Toxicology)
State-of-the-Art "Materials Science" in Poland submission deadline 20 Mar 2027 | Viewed by 21 | Submission Open
Keywords: functional materials; biomaterials; nanomaterials; biopolymers; soft matter; molecular encapsulation; smart materials; material characterization; polymer composites; catalysis
(This special issue belongs to the Section Materials Science)
Mechanisms, Diagnosis, and Treatment of Kidney Disease
edited by Zesergio Melo
submission deadline 25 Mar 2027 | Viewed by 360 | Submission Open
Keywords: kidney disease; biomarkers; diagnosis; pathophysiology; therapeutics; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cancer Metabolism as a Therapeutic Target: From Mechanisms to Therapies
edited by
submission deadline 25 Mar 2027 | Viewed by 70 | Submission Open
Keywords: metabolism; tumor microenvironment; tracing; molecular imaging; therapy; omics; drug response; cancer; immune populations
(This special issue belongs to the Section Molecular Oncology)
Nutritional and Metabolic Perspectives in Polyendocrine Metabolic Ovarian Syndrome (PMOS): From Polycystic Ovarian Syndrome (PCOS) to Polyendocrine-Metabolic Disorder
edited by , , Roberto Baldelli and
submission deadline 25 Mar 2027 | Viewed by 4 | Submission Open
Keywords: nutritional status; dietary patterns; nutraceuticals; precision nutrition; polyendocrine metabolic ovarian syndrome; endocrine-metabolic disorder; women’s health; insulin resistance; adipose tissue dysfunction; chronic low-grade inflammation; body composition; obesity; cardiometabolic risk; lean mass; physical activity
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Biophysical Characterization and Molecular Engineering of Multidomain Proteins (4th Edition) submission deadline 26 Mar 2027 | 3 articles | Viewed by 3672 | Submission Open
Keywords: multidomain proteins; protein dynamics; domain interactions; allosteric regulation; protein engineering; SAXS; Cryo-EM; protein NMR; computational modeling; protein design
(This special issue belongs to the Section Molecular Biophysics)
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