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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Latest Advances in Oxidative Stress and Brain Injury

edited by

Vittorio Fineschi

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4352 | Submission Open

Keywords: measurement of ROS; pathology of brain injuries; traumatic brain injuries; hypoxic– ischemic brain damage; experimental models of brain injury; targeted therapy of brain injuries; drug abuse and ROS; histological diagnosis of brain injuries; epigenetics of brain injuries; miRNA and prognosis of neural damage; novel approaches and proofs of principle in therapy; quality of life after brain injury

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Molecules from Food or Other Natural Sources Against Cancer: 2nd Edition

edited by

Alessandro Maugeri

and

Michele Navarra

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4347 | Submission Open

Keywords: cancer; natural bioactive molecules; natural products; tumor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Regulation and Application of Bioactive Metabolites in Plants

edited by

Aoxue Luo

and

Yijun Fan

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4320 | Submission Open

Keywords: medicinal plants; biosynthesis; biological activity; regulation; pharmacological mechanism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Hepatocellular Carcinoma: From Carcinogenesis to Liver Transplantation

edited by

Kevin Tak-Pan Ng

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4285 | Submission Open

Keywords: hepatocarcinogenesis; molecular pathogenesis; tumor microenvironment; metabolic dysfunction-associated fatty liver disease (MAFLD); metastasis; genetic and epigenetic alterations; biomarkers; precision oncology; targeted therapy; immunotherapy; therapy resistance; immune escape; tumor recurrence; transplant oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular Insight into Bone Diseases

edited by Gaia Palmini

submission deadline 20 Mar 2026 | 4 articles | Viewed by 4243 | Submission Open

Keywords: mineralization; bone diseases; rare bone diseases; non-coding RNAs; fibrous bone dysplasia; tumoral calcinosis; osteosarcoma; Ewing sarcoma; osteoporosis; Gorham-Stout disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Adapter CAR T Cells: From the Idea to the Clinic

edited by

Michael P. Bachmann

submission deadline 20 Mar 2026 | 1 articles | Viewed by 4160 | Submission Open

Keywords: CAR T cell therapy; chimeric antigen receptor; bispecific antibody; target module; autoimmune diseases; solid tumors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antiviral Drugs Discovery

edited by

Dongwei Kang

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4120 | Submission Open

Keywords: antiviral agents; organic synthesis and medicinal chemistry; biological activity; drug design and computational chemistry; drug discovery and development

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Natural Products in Treating Human Diseases

edited by Luís R. Silva

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4113 | Submission Open

Keywords: natural products; phytochemicals; biological potential; pharmacological activity; health promoters; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Processes and Applications of Plasma in Liquids

edited by

Ricardo Molina

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4105 | Submission Open

Keywords: plasma in liquids; water decontamination; plasma-activated water; hydrogels; plasma medicine; polymerization in liquids; plasma agriculture

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Sepsis: Pathogenesis, Biomarkers, Treatments and Prognosis

edited by Francesca Innocenti

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4064 | Submission Open

Keywords: sepsis phenotypes; hemodynamic stabilization; fluids; vasopressors; diagnostic biomarkers; tailored approach; immune modulation; immunomodulatory therapy; prognostic stratification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling the Genetic Background of Neurological Disorders: 2nd Edition

edited by

Vasileios Siokas

Efthimios Dardiotis

and

Ioannis Liampas

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3934 | Submission Open

Keywords: neurological disorders; neurogenetics; personalized treatments; gene-association studies; genetics; genome-wide association studies; genetic linkage studies

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Gut-Brain Axis: Genomic and Metagenomic Involvement

edited by

Maria Gazouli

and Elias Odusseas Tzavellas

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3919 | Submission Open

Keywords: gut– brain axis; central nervous system; gastrointestinal tract; genomic; metagenomic

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Structural Research Advances in Model Plants (Second Edition)

edited by

Ioannis-Dimosthenis Adamakis

submission deadline 20 Mar 2026 | 3 articles | Viewed by 3896 | Submission Open

Keywords: A. thaliana; plant biology; model organisms; plant models; non-model plant models

(This special issue belongs to the Section Molecular Plant Sciences)

Exploring Phage–Host Interactions: Novel Findings and Perspectives

edited by

Luís Melo

submission deadline 20 Mar 2026 | 4 articles | Viewed by 3776 | Submission Open

Keywords: bacteriophages; phage therapy; phage/bacteria interactions; genomics; transcriptomics; proteomics; metabolomics; biofilms

(This special issue belongs to the Section Molecular Microbiology)

Advanced Molecular Research on Retinopathy and Protection

edited by

Jaeyon Won

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3776 | Submission Open

Keywords: retinopathy; neuroprotection; antioxidants; innovative therapy; emerging technology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fundamental and Translational Insights into Colorectal Cancer

edited by Giuseppe Broggi

submission deadline 20 Mar 2026 | 3 articles | Viewed by 3775 | Submission Open

Keywords: colorectal cancer (CRC); molecular pathways; translational research; immune checkpoint inhibitors; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Drug Discovery and Development Focusing on Natural Products

edited by

Chung-Hsin Wu

and

Szu-Chuan Shen

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3709 | Submission Open

Keywords: natural products; drug R& D; herbal medicine; gut microbiota; mechanism of action; therapeutic targets

(This special issue belongs to the Section Molecular Pharmacology)

Gestational Diabetes Mellitus: Molecular Insights into Pathophysiology, Management and Therapy

edited by

Paweł Jan Stanirowski

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3676 | Submission Open

Keywords: GDM pathogenesis; health programming; pharmacogenomics; life-style interventions; fetal growth disorders; preeclampsia; polyhydramnios; placental origin of disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multiomics and Functional Foods: Molecular Characterization, Structures and Biological Activities

edited by

Chuan Li

and

Jun Yang

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3649 | Submission Open

Keywords: multiomics technologies; functional foods; characterization; structures; biological activities; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Computational Biology: Molecular Dynamics Simulation of Biomolecules

edited by

Paulino Gómez-Puertas

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3618 | Submission Open

Keywords: computational biology; molecular dynamics; molecular simulation of rare diseases; computational design of antimicrobials; computational design of antivirals; molecular simulation of cancer-related processes; computational design of anti-cancer molecules; molecular simulation of biotechnology processes

(This special issue belongs to the Section Molecular Informatics)

Molecular Insights into Role of Anthranilic Acid in Neuropsychiatric Diseases

edited by

Gregory F. Oxenkrug

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3589 | Submission Open

Keywords: anthranilic acid; Alzheimer’ s disease; autism; schizophrenia; bipolar disorder; major depressive disorder; post-partum depression; COVID-19; interferons; attention deficit disorder; cognitive impairment; G-protein-coupled receptor 109A; microbiome; gut– brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Cancer Biomarkers and Metabolic Vulnerabilities

edited by Francesca Bersani

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3568 | Submission Open

Keywords: cancer metabolism; cancer biomarkers; liquid biopsy; therapeutic targets; metabolic rewiring

(This special issue belongs to the Section Biochemistry)

Antifungal Potential of Botanical Compounds

edited by Francisca Sempere-Ferre

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3553 | Submission Open

Keywords: botanical compounds; antifungal agents; natural products; secondary metabolites; fungal growth inhibition; bioactive plant extracts; eco-friendly antifungals; natural product chemistry; sustainable antifungal solutions; plant-derived bioactives

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Food Processing Industry’s 200th Anniversary: Bioactive Compounds, Antioxidants, and Potential Health Benefits (2nd Edition)

edited by

Vassilis Athanasiadis

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3520 | Submission Open

Keywords: antioxidants; bioactive compounds; food processing; functional foods; green processes; health potentials; molecular mechanisms; polyphenols; shelf life; vitamins

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Immunosuppressive Therapy

edited by

Marta Grabowska

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3455 | Submission Open

Keywords: immunosuppressive drugs; calcineurin inhibitors; corticosteroids; inhibitors of purine synthesis; mammalian target of rapamycin inhibitors; biological treatment; cell-based therapies; biomarkers; genetic profiling

(This special issue belongs to the Section Molecular Immunology)

Signalling Pathways in Metabolic Diseases and Cancers

edited by

Sabrina Bossio

submission deadline 20 Mar 2026 | 3 articles | Viewed by 3436 | Submission Open

Keywords: cancer; prostate cancer; molecular signalling pathway; metabolic diseases; diabets; immunotherapy; immunological diseases

(This special issue belongs to the Section Biochemistry)

Pathogenesis of Preeclampsia: From a Molecular Perspective

edited by Jezid Miranda

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3352 | Submission Open

Keywords: preeclampsia; immune system; molecular mechanisms in preeclampsia; angiogenic factors; gene regulation; epigenetics; transcription factors in preeclampsia; translational research in preeclampsia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Dynamics Simulation of Biomolecules

edited by

Pavel Rehak

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3332 | Submission Open

Keywords: molecular dynamics simulations; biochemical processes; biomaterial properties

(This special issue belongs to the Section Molecular Biophysics)

Metabolomics in Oncology

edited by

Susan Costantini

and Elena Di Gennaro

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3269 | Submission Open

Keywords: metabolome; cancer; oncology; nuclear magnetic resonance; mass spectrometry

(This special issue belongs to the Section Molecular Oncology)

Structure-Based Design of Drugs and Biologically Active Molecules Based on Computer-Aided Drug Discovery

edited by

Cleydson Breno Rodrigues dos Santos

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3158 | Submission Open

Keywords: drug design; virtual screening; bioinformatics; chemoinformatics; quantum chemistry

(This special issue belongs to the Section Molecular Informatics)

How Aging Results in Cognitive Decline: Molecular Mechanisms

edited by Holly Christian Hunsberger

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3120 | Submission Open

Keywords: aging; memory; hippocampus; neurodegeneration; sex; gender; exercise; synapses; metabolism; mitochondria

(This special issue belongs to the Section Molecular Neurobiology)

Investigation of Natural Products as Sources of Bioactive Molecules, 2nd Edition

edited by

Stefania Garzoli

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3069 | Submission Open

Keywords: metabolomic; secondary metabolites; phytochemical analysis; bioactivity; chemical investigation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Electrochemistry: Molecular Advances and Challenges

edited by

Miguel A. Esteso

submission deadline 20 Mar 2026 | 3 articles | Viewed by 3038 | Submission Open

Keywords: fundamental electrochemistry; electroanalytical techniques; sensors and biosensors; nano-electrochemistry; electrochemical energy production and storage; environmental electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Nanotechnology and Nanomedicine: Approaches, Challenges and Translation for Tissue Regeneration

edited by

Dinesh Kumar Srinivasan

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3033 | Submission Open

Keywords: nanotechnology; bone regeneration; skin regeneration; cardiac tissue regeneration; brain tissue regeneration; drug delivery system; targeted therapy

(This special issue belongs to the Section Molecular Nanoscience)

Medicinal Mechanisms of Biologically Active Compounds in Cancer

edited by

Karthik Gourishetti

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3020 | Submission Open

Keywords: biologically active compounds; cancer treatment; apoptosis; tumor growth; natural products; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Modelling in Material Science

edited by

Aggelos Avramopoulos

and

Filippos Sofos

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3005 | Submission Open

Keywords: molecular materials; molecular structure; molecular modelling; material design

(This special issue belongs to the Section Materials Science)

New Research on the Biological Activities of Natural Components and Their Application

edited by

Željana Fredotović

submission deadline 20 Mar 2026 | 3 articles | Viewed by 2992 | Submission Open

Keywords: natural compounds; traditional and medicinal plants; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Molecular Therapeutics for HIV Co-Infections

edited by

Vishwanath Venketaraman

and

Selvakumar Subbian

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2950 | Submission Open

Keywords: HIV co-infections; molecular therapeutics; Mtb; ART; immune responses

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Macro- and Micronutrients in Health and Diseases

edited by

Karolina Orywal

and Mariusz Gryko

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2943 | Submission Open

Keywords: macronutrients; micronutrients; vitamins; macrominerals; trace elements; cancer; obesity; cardiovascular diseases; diabetes; osteoporosis; immune disorders; neurodegenerative diseases

(This special issue belongs to the Section Molecular Biology)

Recent Research on Biomimetic Chromatography, QSAR and Chemoinformatics in Molecular Modeling and Drug Design

edited by

Małgorzata Janicka

submission deadline 20 Mar 2026 | 3 articles | Viewed by 2897 | Submission Open

Keywords: biomimetic chromatography; QSARs; QRARs; molecular modelling; chemoinformatics; pharmacokinetics

(This special issue belongs to the Section Molecular Informatics)

Advancing Occupational Health Through Omics Technologies

edited by

Silvia Vivarelli

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2828 | Submission Open

Keywords: omics technologies; occupational health; biomarkers; personalized risk assessment; workplace exposures; genomics; proteomics; psychosocial factors; disease susceptibility; preventive medicine

(This special issue belongs to the Section Molecular Biology)

Neurodegenerative Disease: From Molecular Basis to Therapy, 4th Edition

edited by

Claudia Ricci

submission deadline 20 Mar 2026 | 4 articles | Viewed by 2796 | Submission Open

Keywords: neurodegenerative diseases; molecular biology; neurogenetics; pathogenesis; therapy; personalized medicine

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Inborn Errors of Immunity

edited by Aleksandra Szczawińska-Popłonyk

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2789 | Submission Open

Keywords: inborn errors of immunity; immune dysregulation; autoimmunity; autoinflammation; organ-specific immunopathology; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Pathogenesis, Biomarkers and Therapeutic Perspectives of Ocular Diseases

edited by

Eugenia Piragine

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2767 | Submission Open

Keywords: ocular diseases; dry eye; glaucoma; diabetic retinopathy; macular degeneration; molecular mechanisms; diagnosis; preclinical research; clinical studies; drug therapy; pharmacology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into the Environmental Toxicity of Contaminants and Risk Mitigation Strategies

edited by

Barbara Mognetti

and

Tiziana Cappello

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2762 | Submission Open

Keywords: microplastic toxicity; environmental pollutants; molecular mechanisms; cell metabolic pathways; in vivo; in vitro; and in silico models; pollutant interactions; risk mitigation strategies

(This special issue belongs to the Section Molecular Toxicology)

The Role of Natural Products in Inflammation

edited by

Antonia Cianciulli

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2711 | Submission Open

Keywords: inflammation; natural products; immunomodulation; bioactive compounds; drug discovery; drug target identification; anti-inflammatory activity; antioxidant activity; cellular signalling pathways

(This special issue belongs to the Section Molecular Pharmacology)

Hormones: Evolutionary and Functional Role

edited by

Giulia Guerriero

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2698 | Submission Open

Keywords: hormone action; brain organization; sexual behavior; endocrine tissue; receptor neuroexpression; endocrine control; endocrine disruption; climate change and reproduction; hormones and evolution

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanism and Therapeutic Approach of Metal Toxicity

edited by Grażyna Gromadzka

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2685 | Submission Open

Keywords: metal toxicity; neurodegenerative disease; cancer; stroke; myocardial infarct; atherosclerosis; cardiovascular disease; metal chelators; therapeutic approach of metal toxicity; cobalt toxicity; copper toxicity; iron toxicity; aluminum toxicity; manganese toxicity; molybdenum toxicity; nickel toxicity; zinc toxicity; lead toxicity

(This special issue belongs to the Section Molecular Toxicology)

New Research in Spatial Proteomics

edited by

Andrew Smith

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2671 | Submission Open

Keywords: spatial proteomics; mass spectrometry imaging; mass cytometry; biomarker; machine learning; spatial biology; molecular pathology; cancer

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanism and Therapeutic Approaches of Breast Cancer, Metastatic Breast Cancer, 3rd Edition

edited by

Mi Kyung Park

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2649 | Submission Open

Keywords: breast cancer; metastatic breast cancer; epithelial-to-mesenchymal transition (EMT); epigenetic and post-translational modifications (PTM); tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 2201-2250 on page 45 of 70.

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