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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Animal Models for Human Diseases
edited by Yuning Song
submission deadline 31 Dec 2025 | 4 articles | Viewed by 4989 | Submission Open
Keywords: animal models; translational research; preclinical studies; biomedical innovation; reproducibility
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeted Delivery of Nucleic Acids
edited by Yong-Serk Park
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4940 | Submission Open
Keywords: nucleic acid delivery; gene delivery; pDNA delivery; siRNA delivery; miRNA delivery; mRNA delivery; CRISPR-Cas delivery; nanoparticle; lipid nanoparticle; targeted therapy
(This special issue belongs to the Section Molecular Biology)
Advances in Pro-Inflammatory and Anti-Inflammatory Cytokines
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4507 | Submission Open
Keywords: pro-inflammation cytokine; anti-inflammation cytokine; chemotherapy; radiotherapy; signal transduction; microbiome– host response; sepsis; bone marrow; GI; brain
(This special issue belongs to the Section Molecular Immunology)
Advancements in Diagnostic and Preventive Pharmacogenomics
edited by Alireza Tafazoli
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4220 | Submission Open
Keywords: genome profiling; pharmacogenetic analysis; diagnostic pharmacogenomics; pre-emptive pharmacogenomics; advanced genotyping technologies
(This special issue belongs to the Section Molecular Pharmacology)
25th Anniversary of IJMS: Updates and Advances in Molecular Nanoscience
edited by Qi Zhang, and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 4101 | Submission Open
Keywords: nanotechnology; nanomaterials; nanomedicine; nanostructures; 2D materials; smart nanomaterials; nanocatalysts; nanozymes
(This special issue belongs to the Section Molecular Nanoscience)
Advances in the Relationship Between Diet and Insulin Resistance
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4080 | Submission Open
Keywords: insulin resistance; lipotoxicity; lipid metabolism; type 2 diabetes mellitus; dietary lipids; lipidomics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Dietary Supplements: A Delicate Balance Between Benefit and Harm
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 4040 | Submission Open
Keywords: dietary supplements; antioxidants; skin; ageing; wellness
(This special issue belongs to the Section Bioactives and Nutraceuticals)
25th Anniversary of IJMS: Updates and Advances in Molecular Genetics and Genomics submission deadline 31 Dec 2025 | 3 articles | Viewed by 3965 | Submission Open
Keywords: molecular genetics; genomics; precision medicine; genetic diagnostics; gene therapy; next-generation sequencing (NGS); pharmacogenomics; epigenetics; forensic genomics; translational genomics; genome replication; gene expression; cell stress; cell cycle; cell signaling; macromolecular surveillance and turnover; molecular evolution
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Advances and Novel Biomarkers in Gastrointestinal Cancers submission deadline 31 Dec 2025 | 1 articles | Viewed by 3563 | Submission Open
Keywords: gastrointestinal cancers; liquid biopsy; circulating biomarkers; minimal residual disease; early cancer detection; tumor-agnostic assays; molecular diagnostics; precision oncology; predictive biomarkers; translational research
(This special issue belongs to the Section Molecular Oncology)
Cutting-Edge Insights into Bacterial Infection and Host Immune Response
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 3541 | Submission Open
Keywords: bacteria– host interaction; virulence factors; cellular and molecular immune response; immune evasion mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Functional Food Ingredients in Immunity Improvement submission deadline 31 Dec 2025 | 1 articles | Viewed by 3288 | Submission Open
Keywords: functional food ingredients; bioactive compounds; health potentials; food processing and immunomodulation; green extraction techniques; molecular mechanisms; nutritional immunology; dietary intervention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Biomarkers for Targeted Therapies
edited by Vija Lavinia
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3250 | Submission Open
Keywords: biomarkers; molecular targeted radiotherapies; prognostic biomarkers; predictive biomarkers; single or composite biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Ion and Molecule Transport in Membrane Systems, 6th Edition submission deadline 31 Dec 2025 | 4 articles | Viewed by 3142 | Submission Open
Keywords: ion and molecular transport; physical chemistry; chemical physics; transport mechanisms; living systems; biological and artificial membranes; biomimetic structure; structure– property relationships; thermodynamics; irreversible thermodynamics; equilibriums; kinetics
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Urologic Cancers: Molecular Basis for Novel Therapeutic Approaches
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3011 | Submission Open
Keywords: urologic cancers; prostate cancer; urothelial cancer; renal cell cancer; genomics; proteomics; biomarkers; molecular pathways
(This special issue belongs to the Section Molecular Oncology)
The Biological Activities of Curcumin and Its Analogues
edited by Francis Johnson
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2861 | Submission Open
Keywords: curcumin; analogues; natural compounds; inflammation; tissue reconstruction
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanism Involved in Cancer Metastasis
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2717 | Submission Open
Keywords: cell motility; cell migration; spheroid; metastasis; extracellular matrix; cell architecture; lamellipodia; epithelial-mesenchymal transition EMT; videomicroscopy; confocal microscopy; animal model
(This special issue belongs to the Section Molecular Oncology)
25th Anniversary of IJMS: Advances in Physical Chemistry and Chemical Physics submission deadline 31 Dec 2025 | 3 articles | Viewed by 2616 | Submission Open
Keywords: molecular dynamics; quantum chemistry; spectroscopic techniques; supramolecular interactions; computational modeling; AI in chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Selected Papers from the 5th International Symposium on Frontiers in Molecular Science (ISFMS)
edited by , , , Atsushi Shiozaki and Akiyuki Taruno
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2449 | Submission Open
Keywords: protein structure and function; multidomain proteins; drug design and drug resistance; enzymes; molecular biology of galectins; glycobiophysics; NMR spectroscopy; specific sensory systems; brain and systemic function
(This special issue belongs to the Section Biochemistry)
25th Anniversary of IJMS: Updates and Advances in "Materials Science" Section submission deadline 31 Dec 2025 | 1 articles | Viewed by 1978 | Submission Open
Keywords: nanomaterials; functional polymers; bio-inspired systems; complex intelligent; responsive materials
(This special issue belongs to the Section Materials Science)
Physicochemical Properties and Applications of Nanomaterials in Biology and Medicine
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1871 | Submission Open
Keywords: nanoparticle; nanomaterial; biomedicine; synthesis; physicochemical properties; imaging; therapy; contrast agent; therapeutic agent
(This special issue belongs to the Section Molecular Nanoscience)
Biomolecular Structure, Function and Interactions: 2nd Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1871 | Submission Open
Keywords: biophysical chemistry; protein– protein interactions; protein– DNA interactions; protein– ligand interactions; receptor– ligand interactions; biomolecular structure and function; protein folding and stability
(This special issue belongs to the Section Biochemistry)
25th Anniversary of IJMS: Updates and Advances in Molecular Informatics submission deadline 31 Dec 2025 | 3 articles | Viewed by 1865 | Submission Open
Keywords: AI-guided drug repurposing; virtual screening in personalized medicine; machine learning for toxicity prediction; network-based biomarkers in complex diseases; in silico pharmacokinetics and ADMET profiling; data-driven materials design; deep learning for molecular property prediction; AI-assisted nanomaterial synthesis; systems biology models for metabolic engineering
(This special issue belongs to the Section Molecular Informatics)
Advanced Technologies and Molecular Approaches in Brain Disease Diagnosis and Therapy
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1755 | Submission Open
Keywords: neurodegenerative diseases; brain cancer; nanotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Research Progress in Cellular Senescence in Health and Disease
edited by and Mirella Falconi
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1725 | Submission Open
Keywords: senotherapy; cellular senescence; physiological relations; pathological relations; cell biology in aging; age-related diseases; senescence in mesenchymal stroma cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Genome Evolution and Environmental Adaptation
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1724 | Submission Open
Keywords: plant phylogeny; genome evolution; molecular evolution of cytoplasmic genomes; species divergence
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into RNA Diseases
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1677 | Submission Open
Keywords: RNA splicing; RNA modification; RNA processing; translation; RNA transport
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Research and Advances in Ocular Disease
edited by Da-Wen Lu
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1577 | Submission Open
Keywords: ophthalmology; AI; ocular; eye diseases; retina; cornea; glaucoma; neuro-ophthalmology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Ovarian Cancer Metastasis and Chemotherapy Resistance submission deadline 31 Dec 2025 | 1 articles | Viewed by 1534 | Submission Open
Keywords: ovarian cancer; metastasis; biomarkers; chemotherapy resistance; tumor microenvironment; peritoneal– cancer cell interactions; proteomics; novel therapeutic targets
(This special issue belongs to the Section Molecular Oncology)
Advances in Conventional Tree Breeding: Integrating Phenotypic Selection, Genetic Gain, and Sustainable Forest Management
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1459 | Submission Open
Keywords: forest trees; genetic breeding; conventional tree breeding; forest management; forest tree varieties; modern molecular technology; genetic engineering
(This special issue belongs to the Section Molecular Plant Sciences)
Melanoma: From Molecular Pathology to Therapeutic Approaches, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1391 | Submission Open
Keywords: melanoma; pathology; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Focus on Plant Biotechnology and Molecular Breeding submission deadline 31 Dec 2025 | 3 articles | Viewed by 1342 | Submission Open
Keywords: genetic engineering; plant transformation; applied biotechnology; functional genomics; crop plants; crop improvement; plant tissue cultures; secondary metabolites
(This special issue belongs to the Section Molecular Plant Sciences)
Advanced Research of Plant-Pathogen Interaction
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1305 | Submission Open
Keywords: molecular plant-pathogen interactions; pathogen detection; secondary metabolism; multi-omics approaches; antibiotic resistance
(This special issue belongs to the Section Molecular Plant Sciences)
Highlights in Pathophysiology and Treatment of Osteoarthritis submission deadline 31 Dec 2025 | 1 articles | Viewed by 1258 | Submission Open
Keywords: osteoarthritis; pathophysiology (cytokines; adipokines; chemokines; epigenetics; microbiome); cartilage; synovial membrane; subchondral bone; treatment; disease-modifying osteoarthritis drugs; non-pharmacological treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nanobiomaterials and Beyond: Innovations in Drug Delivery, Diagnostics, and Therapeutics submission deadline 31 Dec 2025 | 2 articles | Viewed by 1150 | Submission Open
Keywords: nanobiomaterials; drug delivery systems; targeted drug delivery; controlled drug release; stimulus-responsive nanomaterials; biocompatibility; biodegradability; functionalized nanocarriers; theranostics; nanocarriers for cancer therapy; tumor-targeted drug delivery; organ-specific delivery systems; pH-responsive materials; temperature-sensitive nanobiomaterials; light-activated drug delivery; enzyme-responsive systems; multimodal nanomaterials; translational nanomedicine; computational modeling in nanobiomaterials; preclinical studies of nanomaterials
(This special issue belongs to the Section Materials Science)
Advances in Forensic Molecular Biology and Genetics
edited by
submission deadline 31 Dec 2025 | Viewed by 1146 | Submission Open
Keywords: nuclear and mt-DNA; rapid DNA analysis; next-generation sequencing; mRNA analysis; microbiome analysis; barcode DNA; time since deposition; fluid identification; DNA phenotyping; DNA ancestry
(This special issue belongs to the Section Molecular Biology)
Nature-Inspired and Synthetic Compounds: New Frontiers in Bioactivity and Drug Discovery
edited by and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1113 | Submission Open
Keywords: natural and synthetic products; drug discovery and development; drug repurposing; artificial intelligence and machine learning; biological evaluation; healthcare; green and sustainable chemistry; natural and synthetic drug applications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Biology of Human Reproduction
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1105 | Submission Open
Keywords: human reproduction; genomics; transcriptomics; proteomics; imaging technologies
(This special issue belongs to the Section Molecular Biology)
Advances in Inflammasomes
edited by
submission deadline 31 Dec 2025 | Viewed by 1044 | Submission Open
Keywords: inflammasome; pyroptosis; innate immunity; cancer; neurodegenerative diseases; microbiota; gasdermin; ninjurin; drug screening; personalized treatments; multi-omics analysis
(This special issue belongs to the Section Molecular Immunology)
25th Anniversary of IJMS: Updates and Advances in Molecular Pharmacology
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1025 | Submission Open
Keywords: precision medicine; pharmacogenomics; targeted protein degradation (TPD); molecular pharmacology; RNA Therapeutics; novel drug modalities; proteomics; transcriptomics; personalized drug therapy
(This special issue belongs to the Section Molecular Pharmacology)
Food Allergy: Molecular Mechanisms, Clinical Challenges, and Future Directions
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 991 | Submission Open
Keywords: food allergy; allergen; environmental exposures; gut microbiome; non-IgE-mediated pathways
(This special issue belongs to the Section Molecular Immunology)
Upcycling Food Industry By-Products: Bioactive Ingredients for Nutrition and Health submission deadline 31 Dec 2025 | 1 articles | Viewed by 893 | Submission Open
Keywords: bioactive compounds; food by-products; functional foods; molecular mechanisms; polyphenols; oxidative stress; inflammation; nutrigenomics; microbiome; prebiotics; postbiotics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Trends in Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics: 3rd Edition
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 882 | Submission Open
Keywords: Alzheimer’ s disease; pathogenic mechanisms; genomics; epigenetics; biomarkers; prevention; treatment; pharmacogenetics
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Breeding for Important Economic Traits in Livestock submission deadline 31 Dec 2025 | Viewed by 873 | Submission Open
Keywords: molecular breeding; livestock genetics; economic traits; genomic selection; adipogenesis; feed efficiency; disease resistance; non-coding RNAs; multi-omics; genetic improvement
(This special issue belongs to the Section Molecular Biology)
Atherosclerosis and Comorbidities: From Molecular Pathogenesis to Diagnosis and Therapeutic Targets submission deadline 31 Dec 2025 | Viewed by 816 | Submission Open
Keywords: atherosclerosis; comorbidities; lipidology; inflammation; obesity; arterial stiffness; vascular remodeling; cardiovascular risk; cardiovascular diseases; targeted therapies; lifestyle
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Trends in Enzymology submission deadline 31 Dec 2025 | Viewed by 804 | Submission Open
(This special issue belongs to the Section Biochemistry)
Enzymes and Enzyme Inhibitors—Applications in Medicine and Diagnosis, 3rd Edition
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 744 | Submission Open
Keywords: enzyme; enzyme inhibitor; drug target; enzyme deficiency; enzyme overexpression; biomarker; drugs; diagnosis; therapy
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Insights into Plasma in Seed and Plant Treatment submission deadline 31 Dec 2025 | Viewed by 668 | Submission Open
Keywords: seed; plant; plasma; germination; dormancy; sterilization; reactive oxygen species; reactive nitrogen species; molecular mechanism; growth promotion; essential oils; plant stem cells; seed coating and pelleting
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in the Synthesis and Study of Novel Bioactive Molecules submission deadline 31 Dec 2025 | 1 articles | Viewed by 660 | Submission Open
Keywords: organic compounds; metal complexes; bioactive molecules
(This special issue belongs to the Section Biochemistry)
Chelating Ligands in Therapeutics: Recent Advances and Future Directions submission deadline 31 Dec 2025 | Viewed by 632 | Submission Open
Keywords: metal complexes; chelation therapy; chelating agents; diagnostic imaging; metal detoxification; chelation pharmacokinetics
(This special issue belongs to the Section Biochemistry)
Microbial Fermentation: Advances in Synthetic Biology, Metabolic Engineering, and Biomanufacturing
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 618 | Submission Open
Keywords: microbial fermentation; synthetic biology; metabolic engineering; biomanufacturing; industrial biotechnology
(This special issue belongs to the Section Molecular Microbiology)
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