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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Biomarker Advances in Gynecologic Oncology

edited by

E. Sun Paik

submission deadline 31 Jan 2027 | Viewed by 208 | Submission Open

Keywords: gynecologic oncology; epithelial ovarian cancer; prognostic biomarkers; tumor microenvironment; systemic inflammation; precision medicine; targeted therapy; clinical risk stratification

(This special issue belongs to the Section Molecular Oncology)

New Advances in Spinal Cord Injury

edited by

Chih-Wei Zeng

submission deadline 31 Jan 2027 | Viewed by 208 | Submission Open

Keywords: spinal cord injury; neural regeneration; regenerative medicine; stem cell therapy; induced pluripotent stem cells; mesenchymal stem cells; neural progenitor cells; biomaterials; neuroinflammation; neuromodulation

(This special issue belongs to the Section Molecular Neurobiology)

Oxidative Stress in Human Diseases: Molecular Mechanisms, Biomarkers, and Therapeutic Perspectives

edited by

Rossana Morabito

Alessia Remigante

and Sara Spinelli

submission deadline 31 Jan 2027 | Viewed by 206 | Submission Open

Keywords: oxidative stress; ROS; antioxidants; redox biology; inflammation; biomarkers; chronic diseases; neurodegeneration; cancer; metabolism; mitochondria; aging; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Quantum Neuroactivity

edited by

Mihai V. V. Putz

submission deadline 31 Jan 2027 | Viewed by 205 | Submission Open

Keywords: neurosciences; neurochemistry; neurobiology; quantum theory and computation; neuromorphisms; QSAR (quantitative structure-activity relationships); bio- and nano-materials; (artificial) neural networks.

(This special issue belongs to the Section Molecular Neurobiology)

Research on Plant-Microbe Interaction

edited by Yelda Özden Çiftçi

submission deadline 31 Jan 2027 | Viewed by 198 | Submission Open

Keywords: biofertilizers; plant-microbe interactome; synthetic symbiosis; rhizosphere engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Synaptic Dysfunction in Neurodegenerative Diseases: From Molecular Mechanisms to Therapeutic Strategies

edited by

Giulia Romano

submission deadline 31 Jan 2027 | Viewed by 193 | Submission Open

Keywords: synaptic dysfunction; neurodegeneration; synaptic vesicle recycling; cytoskeleton and microtubules; neurotransmission; neuromuscular junction (NMJ); RNA metabolism; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Research on Plant-Growth-Promoting Rhizobacteria

edited by

Dragana Miljaković

submission deadline 31 Jan 2027 | Viewed by 185 | Submission Open

Keywords: plant growth promoting rhizobacteria; plant–microbe interactions; microbiome-based selection; microbiome engineering; synthetic communities; biofertilization; biocontrol; stress tolerance; smart delivery methods

(This special issue belongs to the Section Molecular Microbiology)

Machine Learning for Peptide and Protein Function Prediction

edited by

Ching-Tai Chen

and Hsin-Nan Lin

submission deadline 31 Jan 2027 | Viewed by 184 | Submission Open

Keywords: protein language models (PLMs); deep learning; sequence-based function prediction; therapeutic peptides; post-translational modification (PTM); sequence-structure mapping; multi-functional peptides; residue-level prediction; bioinformatics; transfer learning

(This special issue belongs to the Section Molecular Informatics)

Recent Advances in Wound Healing: 3rd Edition

edited by

Alina Maria Holban

and

Carmen Curutiu

submission deadline 31 Jan 2027 | Viewed by 176 | Submission Open

Keywords: management of wounds; nanobiomaterials; infection control; chronic wounds; biofilm infections; wound dressings; tissue engineering; wound healing

(This special issue belongs to the Section Molecular Biology)

New Advances in Plant–Microbe Interactions

edited by

Mohamed Farissi

and Ahmed El Moukhtari

submission deadline 31 Jan 2027 | Viewed by 173 | Submission Open

Keywords: plant–microbe interactions; plant microbiome; plant-beneficial microorganisms; multi-omics; sustainable agriculture; microbial diversity

(This special issue belongs to the Section Molecular Plant Sciences)

Mitochondrial Dysfunction and Chronic Diseases: Molecular Insight and Therapeutic Opportunities

edited by

Manivannan Yegambaram

submission deadline 31 Jan 2027 | Viewed by 153 | Submission Open

Keywords: mitochondrial dysfunction; redox signaling; metabolism; mitochondrial dynamics; mitochondrial-targeted therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pseudopeptidases: From Structure to Function in Health and Disease

edited by

Elena N. Elpidina

and

Yakov E. Dunaevsky

submission deadline 31 Jan 2027 | Viewed by 135 | Submission Open

Keywords: pseudopeptidases; pseudoenzymes; inactive homologs of peptidases; peptidases; protein structure; protein function

(This special issue belongs to the Section Biochemistry)

Molecular Research in Biochar

edited by

Muhammad Kashif Irshad

submission deadline 31 Jan 2027 | Viewed by 134 | Submission Open

Keywords: engineered biochar; molecular mechanisms; surface complexation; heavy metal(loid) immobilization; PFAS; microplastics; colloid-facilitated transport; spectroscopic characterization; density functional theory; machine learning; soil microbiology

(This special issue belongs to the Section Materials Science)

Metalloproteins in Biomedicine: From Molecular Mechanisms and Biomarkers to Diagnostics, Therapeutics and Nanotechnology

edited by

Kamil Gareev

and

Maxim Shevtsov

submission deadline 31 Jan 2027 | Viewed by 134 | Submission Open

Keywords: metalloproteins; biomarkers; nanomedicine; immunology; molecular mechanisms; nanotechnology; biosensing

(This special issue belongs to the Section Biochemistry)

Mechanism of SARS-CoV-2 Interactions with Tissue Cells

edited by Matias Nunes Frizzo and

Monica Gelzo

submission deadline 31 Jan 2027 | Viewed by 129 | Submission Open

Keywords: SARS‑CoV‑2; virus–cell interaction; viral pathogenesis; immune response; inflammation and tissue injury; clinical and laboratory biomarkers

(This special issue belongs to the Section Molecular Immunology)

Ventricular Function and Pathophysiology in Cardiovascular Diseases

edited by

Filip Konecny

submission deadline 31 Jan 2027 | Viewed by 128 | Submission Open

Keywords: heart failure; ventricular function; pressure–volume analysis; cardiac hemodynamics; ventricular remodeling; cardiovascular pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms of Cardiotoxicity in Anticancer Therapies

edited by Sheetalnath Rooge

submission deadline 31 Jan 2027 | Viewed by 124 | Submission Open

Keywords: cardiotoxicity; cardiac hypertrophy; mitochondrial dysfunction; immune response; autophagy; mitophagy; lipophagy; apoptosis; ferroptosis; DNA damage; iron overload; lipid peroxidation; ROS production; Ca2+ homeostasis; microRNA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

State-of-the-Art Molecular Neurobiology in Turkey

edited by Bilal Çiğ, Atay Vural and Aydan Köysüren

submission deadline 31 Jan 2027 | Viewed by 113 | Submission Open

Keywords: molecular neurobiology; ion channels; neurophysiology; neuropharmacology; neuroinflammation; neurodegeneration; glia biology; synaptic signaling; oxidative stress; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Hydrogel Materials for Regenerative Medicine: Molecular Perspectives

edited by

Yiran Li

submission deadline 31 Jan 2027 | Viewed by 112 | Submission Open

Keywords: supramolecular hydrogels; adaptive materials; biomimetic material; stimuli-responsive hydrogels; tissue engineering; regenerative medicine; phase separation hydrogel

(This special issue belongs to the Section Materials Science)

AI-Powered Precision Nanomedicine for Brain Delivery

edited by João Dias-Ferreira

submission deadline 31 Jan 2027 | Viewed by 111 | Submission Open

Keywords: neuroscience; glioblastoma; AI-driven healthcare; nanotargeted drug delivery; central nervous system; genic edition and therapy

(This special issue belongs to the Section Molecular Pharmacology)

Genomics and Molecular Mechanisms of Cancer

edited by

Raffaella Lazzarini

submission deadline 31 Jan 2027 | Viewed by 110 | Submission Open

Keywords: carcinogenesis; genetic and epigenetic alterations; cancer molecular mechanisms; cancer regulatory networks

(This special issue belongs to the Section Molecular Oncology)

Epithelial Dysfunction in Allergic Diseases

edited by

Sena Ardicli

submission deadline 31 Jan 2027 | Viewed by 109 | Submission Open

Keywords: epithelial dysfunction; epithelial barrier theory; allergic diseases; barrier integrity; immune-epithelial crosstalk; type 2 inflammation; mucosal immunology; environmental exposures; tissue remodeling; translational allergy research

(This special issue belongs to the Section Molecular Immunology)

Acute Kidney Injury: From Pathogenesis to Targeted Therapy

edited by

Milan Ivanov

submission deadline 31 Jan 2027 | Viewed by 108 | Submission Open

Keywords: AKI; pathogenesis; biomarkers; targeted therapy; ischemia–reperfusion injury; inflammation; apoptosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Functional Materials for Electrochemical Energy Conversion and Storage

edited by

Mohammad R. Thalji

and

Farzaneh Mahmoudi

submission deadline 31 Jan 2027 | Viewed by 104 | Submission Open

Keywords: advanced functional materials; molecular design; electrochemical energy conversion; energy storage; electrocatalysis; hydrogen/oxygen production; batteries; supercapacitors; interface/molecular engineering; charge-transfer mechanisms

(This special issue belongs to the Section Materials Science)

Rare Genetic Diseases: From Molecular Mechanisms to Therapeutic Strategies—2nd Edition

edited by

Maria Arnedo

submission deadline 31 Jan 2027 | Viewed by 101 | Submission Open

Keywords: rare genetic disease; innate metabolic errors; neurodegenerative diseases; therapeutic; molecular diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular and Molecular Toxicology of Emerging Environmental Pollutants

edited by

Kyoungtae Kim

submission deadline 31 Jan 2027 | Viewed by 99 | Submission Open

Keywords: environmental pollutant; cellular toxicology; man-made nanoparticles; toxicological mechanisms; 6PPD/6PPD-Q

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms Governing Immune Regulation and Tumor Suppression in Cancer

edited by

Cleber Machado-Souza

submission deadline 31 Jan 2027 | Viewed by 97 | Submission Open

Keywords: tumor suppression; immune regulation; cancer signaling; tumor microenvironment; epigenetics; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Role of Lipids in Sarcopenia and Atrophy of Skeletal Muscle

edited by Sara Baldelli and

Serena Castelli

submission deadline 31 Jan 2027 | Viewed by 97 | Submission Open

Keywords: sarcopenia; skeletal muscle atrophy; lipid metabolism; oxidative stress

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Medicinal Plants and Natural Products: Molecular Mechanisms and Therapeutic Applications

edited by

Mary Anne Medeiros Bandeira

submission deadline 31 Jan 2027 | Viewed by 97 | Submission Open

Keywords: medicinal plants; natural products; phytochemicals; molecular pharmacology; signal transduction; bioactive compounds; oxidative stress; inflammation; drug discovery; translational medicine

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Medicinal Chemistry: Design, Synthesis and Application

edited by

Vasilii Otvagin

submission deadline 31 Jan 2027 | Viewed by 95 | Submission Open

Keywords: medicinal chemistry; drug design; synthesis and analysis; biological chemistry; bioactive natural products

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Molecular and Cellular Pathology of Cancer Research

edited by

Onur Bender

and

Ahmet Acar

submission deadline 31 Jan 2027 | Viewed by 95 | Submission Open

Keywords: cancer molecular pathology; cancer genomics; experimental therapeutics; inhibitors; immuno-oncology; tumor heterogeneity; liquid biopsy; organoids; spatial biology; digital PCR; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Hepatocellular Carcinoma: Mechanisms, Therapeutics and Liver Transplantation

edited by

Kevin Tak-Pan Ng

submission deadline 31 Jan 2027 | Viewed by 93 | Submission Open

Keywords: hepatocarcinogenesis; molecular pathogenesis; tumor microenvironment; metabolic dysfunction-associated fatty liver disease (MAFLD); metastasis; genetic and epigenetic alterations; biomarkers; precision oncology; targeted therapy; immunotherapy; therapy resistance; immune escape; tumor recurrence; transplant oncology

(This special issue belongs to the Section Molecular Oncology)

New Advances in Alkaloids and Their Synthetic Derivatives

edited by Karol Kacprzak

submission deadline 31 Jan 2027 | Viewed by 92 | Submission Open

Keywords: alkaloids; pseudoalkaloids; alkaloids modification; alkaloids synthesis; alkaloids conjugates; alkaloids in stereoselective synthesis; alkaloids bioactivity; bioproduction or isolation of alkaloids; phytochemistry; natural products

(This special issue belongs to the Section Biochemistry)

Molecular Therapeutic Mechanisms and Drug Discovery for Obesity and Nephropathy

edited by

Anusorn Lungkaphin

submission deadline 31 Jan 2027 | Viewed by 90 | Submission Open

Keywords: obesity; diabetes mellitus; kidney injury; treatment and prevention of nephropathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Vaccine Immunology Research in Veterinary Medicine

edited by

Yue Zhang

submission deadline 31 Jan 2027 | Viewed by 90 | Submission Open

Keywords: veterinary vaccines; vaccine immunology; nanoparticle vaccines; animal infectious diseases; adjuvants; antigen delivery

(This special issue belongs to the Section Molecular Immunology)

Bioactive Potentials of Phytochemicals: Anti-Inflammatory, Antibacterial, and Antitoxic Functions

edited by

Juliana Felix-Silva

submission deadline 31 Jan 2027 | Viewed by 89 | Submission Open

Keywords: phytochemicals; natural products; anti-inflammatory activity; antibacterial activity; antitoxic activity; anti-venom activity; molecular mechanisms; oxidative stress; bioactive compounds; drug discovery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

In Silico and In Vitro Advancements in Natural-Product-Derived Therapeutics

edited by

Ploenthip Puthongking

submission deadline 31 Jan 2027 | Viewed by 88 | Submission Open

Keywords: biological activity of natural products; natural product chemistry; traditional medicine; molecular docking; network pharmacology; machine learning; in vitro/in vivo experiments

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nutritional Interventions and Metabolic Studies in Diabetes

edited by Sreelakshmi Sankara Narayanan

submission deadline 31 Jan 2027 | Viewed by 88 | Submission Open

Keywords: diabetes mellitus; nutritional interventions; metabolic health; functional foods and nutraceuticals; omics approaches; advanced glycation end products (AGEs)

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Gastrointestinal Injury and Inflammation: Molecular Mechanisms and Therapeutic Insights

edited by Rei Kawashima

submission deadline 31 Jan 2027 | Viewed by 88 | Submission Open

Keywords: gastrointestinal mucosa; mucosal injury; intestinal inflammation; mucosal immunity; epithelial barrier; mucin; goblet cells; mechanosensing; host–microbiota interactions; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Volatile Organic Compound Detection and Analysis

edited by Velmurugan Thavasi

submission deadline 31 Jan 2027 | Viewed by 82 | Submission Open

Keywords: volatile organic compounds; VOC analysis; chemical sensors; mass spectrometry; gas chromatography; breathomics; volatilomics; molecular biomarkers; chemometrics; AI/ML

(This special issue belongs to the Section Biochemistry)

Advances in Metabolomics for Environmental Exposure and Toxicological Research

edited by

Churdsak Jaikang

and Hataichanok Chuljerm

submission deadline 31 Jan 2027 | Viewed by 81 | Submission Open

Keywords: toxicology; metabolomics; environmental health; chemical exposure; biomarkers; environmental metabolomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Anticancer Potential of Natural Products: Molecular Insights and Therapeutic Perspectives

edited by

Nunzio Antonio Cacciola

, Annunziata Corteggio and

Daniela Melillo

submission deadline 31 Jan 2027 | Viewed by 80 | Submission Open

Keywords: natural products; bioactive compounds; anticancer; tumour microenvironment; cancer prevention and therapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Multi-Omics and Molecular Networks in Cardiometabolic

edited by

Andreas Leiherer

submission deadline 31 Jan 2027 | Viewed by 80 | Submission Open

Keywords: cardiometabolic diseases; multi-omics integration; molecular biomarkers; lipidomics; metabolomics; molecular pathophysiology; machine learning; bioinformatics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Glucose in Energy Metabolism: Molecular Perspectives

edited by

Luis Alberto Madrigal-Perez

submission deadline 31 Jan 2027 | Viewed by 79 | Submission Open

Keywords: insulin signaling; metabolic flexibility; oxidative phosphorylation; cellular energetics; metabolic disorders; glucose sensing; ATP production; metabolomics; diabetes; nutrient sensing

(This special issue belongs to the Section Biochemistry)

Physicochemical Properties and Applications of Nanomaterials in Biology and Medicine: 2nd Edition

edited by

Gangho Lee

submission deadline 31 Jan 2027 | Viewed by 78 | Submission Open

Keywords: nanoparticles; nanomaterials; biomedicine; synthesis; physicochemical properties; imaging; therapy; contrast agents; therapeutic agents

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Epidemiology and Pathogenesis of Critical Gram-Negative Pathogens

edited by

Zakuan Zainy Deris

and

Mohd Zulkifli Salleh

submission deadline 31 Jan 2027 | Viewed by 77 | Submission Open

Keywords: Gram-negative bacteria; antimicrobial resistance mechanisms; genomic surveillance; biofilm formation; structural biology; molecular diagnostics; host–pathogen interactions; One Health

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Renal Injury

edited by

Cristián A. Amador

and

Alexis A. Gonzalez

submission deadline 31 Jan 2027 | Viewed by 75 | Submission Open

Keywords: renal inflammation; kidney damage and exercise; tubular injury; glomerular disease; oxidative stress; kidney repair and regeneration; immune–kidney interactions; biomarkers of kidney disease

(This special issue belongs to the Section Molecular Biology)

Glutathione Deficiency and Health Conditions

edited by Vishwanath Venketaraman

submission deadline 31 Jan 2027 | Viewed by 71 | Submission Open

Keywords: neurological disorders; neurodegenerative diseases; ARDS; COPD; aging; cancer; diabetes; glutathione; HIV; tuberculosis

(This special issue belongs to the Section Biochemistry)

Physiological and Molecular Mechanisms of Fruit Growth, Development and Ripening

edited by

Orhan Karakaya

submission deadline 31 Jan 2027 | Viewed by 70 | Submission Open

Keywords: fruit development; fruit ripening; plant physiology; gene expression; metabolomics; hormonal regulation; postharvest biology; fruit quality; abiotic stress; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Toxicity and Genotoxicity Screening of Environmental Stressors

edited by

Karolina Sunjog

submission deadline 31 Jan 2027 | Viewed by 70 | Submission Open

Keywords: environmental stressors; toxicity; genotoxicity; environmental pollutants; emerging contaminants; in vitro models; in vivo models; biomarker analysis; environmental risk assessment

(This special issue belongs to the Section Molecular Toxicology)

Displaying special issue 2601-2650 on page 53 of 64.

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