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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Omics and Network Pharmacology in Phytomedicine and Disease Therapeutics submission deadline 31 Mar 2027 | Viewed by 47 | Submission Open
Keywords: AI-ML; computational biology; drug discovery; enrichment analyses; medicinal plants; network pharmacology; omics; traditional medicine
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Allergic Responses and Allergen Immunotherapy
edited by
submission deadline 31 Mar 2027 | Viewed by 45 | Submission Open
Keywords: allergic rhinitis; asthma; anaphylaxis; allergen-specific immunotherapy (AIT); immune tolerance; food allergy; biomarkers; mucosal immunity; biological therapies; T regulatory cells (Tregs)
(This special issue belongs to the Section Molecular Immunology)
Probiotic Bioactives: Molecular Mechanisms and Applications submission deadline 31 Mar 2027 | Viewed by 44 | Submission Open
Keywords: probiotics; postbiotics; bioactive compounds; bio-preservation; health benefits; lactic acid bacteria; antibacterial; antifungal; functional properties
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Animal Virology: Pathogenesis, Therapeutics, and Natural Products
edited by
submission deadline 31 Mar 2027 | Viewed by 42 | Submission Open
Keywords: virus; pathogenesis; climate change; green alternatives; animal infectious disease; zoonosis; outbreak; natural products
(This special issue belongs to the Section Molecular Microbiology)
The Functional Roles of Non-Coding RNAs in Cancers
edited by
submission deadline 31 Mar 2027 | Viewed by 40 | Submission Open
Keywords: non-coding RNAs; tumorigenesis; drug resistance; biomarkers; RNA-based therapeutics; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms in Inborn Errors of Immunity
edited by Giorgio Costagliola
submission deadline 31 Mar 2027 | Viewed by 40 | Submission Open
Keywords: immunodeficiency; immune dysregulation; genetics; targeted therapies
(This special issue belongs to the Section Molecular Immunology)
Genetic Engineering of Plants for Stress Tolerance, 3rd Edition
edited by
submission deadline 31 Mar 2027 | Viewed by 39 | Submission Open
Keywords: CRISPR-Cas system; RNA interference; abiotic and biotic stresses; transcriptional regulation; post-transcriptional regulation; post-translational modification; genetic evolution; biotechnology; molecular mechanisms; regulatory circuits
(This special issue belongs to the Section Molecular Plant Sciences)
Synthesis and Characterization of Shape Memory Polymers
edited by Bonifacio Alvarado-Tenorio
submission deadline 31 Mar 2027 | Viewed by 36 | Submission Open
Keywords: molecular design of shape-memory polymers; shape-memory polymer synthesis; stimuli-responsive polymer networks; shape-memory polymer nanocomposites; polymer crystallization and phase transitions; thermomechanical characterization; molecular structure-property relationships; two-way and triple-shape memory effects
(This special issue belongs to the Section Materials Science)
Biosynthesis and Functions of Nuclear O-Glycans
edited by Fernando Irazoqui
submission deadline 31 Mar 2027 | Viewed by 31 | Submission Open
Keywords: glycosyltransferases; O-glycosylation; nuclear architecture; chromatin dynamic; nuclear transport; DNA repair; RNA transcription; protein expression
(This special issue belongs to the Section Biochemistry)
Microscopy for Molecular Sciences: Recent Advances in Imaging and Analysis submission deadline 31 Mar 2027 | Viewed by 30 | Submission Open
Keywords: molecular interactions via microscopy; scanning probe microscopy; optical microscopy; spectral microimaging; correlative microscopy; machine learning; image analysis; high-content screening
(This special issue belongs to the Section Molecular Biophysics)
Molecular Regulation of Ornamental Traits, Disease Resistance, and Stress Resilience in Ornamental Fish
edited by
submission deadline 31 Mar 2027 | Viewed by 29 | Submission Open
Keywords: ornamental fish; ornamental traits; molecular breeding; multi-omics; nutrient metabolism; gut microbiota; host immunity; disease resistance; environmental stress; phenotypic plasticity
(This special issue belongs to the Section Molecular Biology)
Cellular and Molecular Mechanisms of Environmental and Drug-Induced Organ Toxicity submission deadline 31 Mar 2027 | Viewed by 29 | Submission Open
Keywords: environmental toxicology; drug-induced organ toxicity; metal toxicity; nanomaterial; oxidative stress; inflammation; regulated cell death; histopathology; molecular toxicology
(This special issue belongs to the Section Molecular Toxicology)
Metabolic Inflammation and Adipose Tissue
edited by
submission deadline 31 Mar 2027 | Viewed by 28 | Submission Open
Keywords: metabolic inflammation; chronic low-grade inflammation; metabolic syndrome; obesity; adipocyte dysfunction; adipose tissue dysfunction; visceral obesity; immunometabolic disorders; insulin resistance; adipokine profile
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms of Insect Adaptation and Resistance
edited by Cristina Yunta Yanes
submission deadline 31 Mar 2027 | Viewed by 26 | Submission Open
Keywords: insecticide resistance; molecular mechanisms; insect molecular biology; insect biochemistry; detoxification enzymes; cytochrome P450; glutathione S-transferases (GSTs); carboxyl/cholinesterases; ABC transporters; target-site resistance; insect genomics; transcriptomics; proteomics; structural biology; molecular evolution; insect adaptation
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Cranium–Brain Interactions in Brain Health and Neurological Disease
edited by Meenakshi Umar
submission deadline 31 Mar 2027 | Viewed by 23 | Submission Open
Keywords: cranium–brain interactions; cranial bone marrow; meninges; neurovascular biology; neuroimmune signaling; neuroinflammation; blood–brain barrier; molecular signaling; cranial development; neurological disorders
(This special issue belongs to the Section Molecular Neurobiology)
Crystal Polymorphism in Nanostructured Materials
edited by Diego Germán Lamas and Analía Leticia Soldati
submission deadline 31 Mar 2027 | Viewed by 22 | Submission Open
Keywords: crystal polymorphism; nanostructured materials; metastable phases; phase stability and transformations; surface and interfacial energies; X-ray diffraction and total scattering; in situ and operando characterization; synchrotron, electron, and neutron techniques; first-principles and atomistic modeling; structure–property relationships
(This special issue belongs to the Section Materials Science)
Advances in Cell and Tissue Ultrastructure: Molecular Mechanisms and Biomedical Applications
edited by Katarzyna Haczkiewicz-Leśniak
submission deadline 31 Mar 2027 | Viewed by 21 | Submission Open
Keywords: cell ultrastructure; tissue ultrastructure; ultrastructural pathology; glomerulonephritis; organelles architecture; neuromuscular disorders; cryo-TEM; advanced electron microscopy techniques; spheroids; gold nanoparticles; vesicles morphology
(This special issue belongs to the Section Molecular Biology)
Long COVID: From Medical Conditions to Molecular Mechanisms
edited by Sándor Szabó and Veronika Müller
submission deadline 31 Mar 2027 | Viewed by 20 | Submission Open
Keywords: long COVID; pathophysiological mechanisms; molecular and cellular mechanisms; cytokine dysregulation; vascular factors; endothelial vs. epithelial cell damage; hormonal changes; gene activation; pro-oncogenic changes; prevalence; clinical manifestations
(This special issue belongs to the Section Molecular Biology)
Computer-Aided Drug Discovery, Including Cheminformatics and Computational Chemistry
edited by
submission deadline 31 Mar 2027 | Viewed by 20 | Submission Open
Keywords: computer-aided drug discovery; computational chemistry; cheminformatics; molecular modeling; molecular docking; virtual screening; molecular dynamics; drug design; artificial intelligence; machine learning
(This special issue belongs to the Section Molecular Informatics)
Molecular Mechanisms of Organ Damage Induced by Anabolic-Androgenic Steroids
edited by
submission deadline 31 Mar 2027 | Viewed by 19 | Submission Open
Keywords: anabolic androgenic steroids; AASs; sudden cardiac death; SCD; doping in sport; molecular analysis; toxicology; testosterone; toxicity; autopsy
(This special issue belongs to the Section Molecular Biology)
Recent Molecular Insights into Parasitic Infections and Evolution
edited by Juan Antonio Venegas
submission deadline 31 Mar 2027 | Viewed by 18 | Submission Open
Keywords: molecular parasitology; parasitic infections; molecular virulence of parasites; molecular evasion of the immune response; parasitic signal transducer systems; molecular evolution of parasites; molecular pathogenesis of parasites; host–parasite interactions at the molecular level; molecular drug resistance
(This special issue belongs to the Section Molecular Biology)
Skeletal Muscle: Metabolism, Aging and Treatment Strategies
edited by Johan Lindqvist
submission deadline 31 Mar 2027 | Viewed by 16 | Submission Open
Keywords: skeletal muscle; whole-body energy homeostasis; aging; muscle metabolism; sarcopenia; skeletal muscle disease
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Cancer Biomarkers: Diagnosis, Prognosis, and Clinical Implications
edited by and
submission deadline 31 Mar 2027 | Viewed by 15 | Submission Open
Keywords: cancer biomarkers; multi-omics; liquid biopsy; precision oncology; early diagnosis
(This special issue belongs to the Section Molecular Oncology)
Advanced Research in Mitochondrial Function
edited by Juan Pablo Muñoz
submission deadline 31 Mar 2027 | Viewed by 14 | Submission Open
Keywords: mitochondrial dysfunction; breast cancer; oxidative stress; endocrine-disrupting chemicals
(This special issue belongs to the Section Molecular Biology)
Plasma–Surface and Plasma–Cell Interactions: Molecular Mechanisms and Applications submission deadline 31 Mar 2027 | Viewed by 13 | Submission Open
Keywords: plasma medicine; plasma theranostics; plasma pharmacology; plasma oncology; plasma bioengineering; plasma agriculture; plasma and food; plasma and automotive; plasma and aerospace; plasma diagnostics; plasma material processing; plasma polymerization and coating; simulation of plasma phenomena during interaction with matter
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advances in Active Ingredients and Health Effects of Plant Extracts and Functional Food
edited by Cong Teng
submission deadline 31 Mar 2027 | Viewed by 13 | Submission Open
Keywords: plant extract; polysaccharides; protein; polyphenols; functional ingredients; structural characterization; health activities
(This special issue belongs to the Section Bioactives and Nutraceuticals)
MicroRNAs and mRNA in Human Health and Disease, 2nd Edition
edited by
submission deadline 31 Mar 2027 | Viewed by 12 | Submission Open
Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA
(This special issue belongs to the Section Molecular Biology)
Sportomics and the Molecular Athlete: Metabolic Stress, Nutrition and Safety in High-Performance Athletes
edited by Luiz-Claudio Cláudio Cameron
submission deadline 31 Mar 2027 | Viewed by 12 | Submission Open
Keywords: sportomics; metabolic stress; personalized nutrition; sex and gender athlete-based analysis; precision sports medicine; athlete safety; unintentional doping; environmental stress; n-of-1 elite-athlete studies
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Psychiatry: From Genetics to Psychopharmacology
edited by
submission deadline 31 Mar 2027 | Viewed by 12 | Submission Open
Keywords: molecular psychiatry; psychiatric genetics; neurodevelopmental disorders; psychopharmacology; precision psychiatry
(This special issue belongs to the Section Molecular Neurobiology)
A New Perspective on Mitochondrial Function in Diseases
edited by Hengbin Wang
submission deadline 31 Mar 2027 | Viewed by 11 | Submission Open
Keywords: mitochondrial function; mitochondrial dysfunction; mitochondrial metabolism; mitochondrial signaling; mitochondrial epigenetics; mitochondria–nucleus communication; bioenergetics; oxidative stress; mitophagy; mitochondrial dynamics; cancer; aging; neurodegeneration; inflammation; therapeutic resistance
(This special issue belongs to the Section Biochemistry)
State-of-the-Art "Physical Chemistry and Chemical Physics" in China
edited by Chen Wu
submission deadline 31 Mar 2027 | Viewed by 11 | Submission Open
Keywords: molecular dynamics; reaction mechanisms; operando characterization; interfacial and surface science; molecular catalysis; electrochemistry and energy conversion; quantum and computational chemistry; machine learning; AI-enabled chemical discovery; biomolecular physical chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Mechanisms of Food Colloidal Interfacial Engineering and Their Applications submission deadline 31 Mar 2027 | Viewed by 10 | Submission Open
Keywords: food colloids; molecular interactions; food interfaces; protein–polysaccharide complexes; pickering emulsions; interfacial adsorption; colloidal delivery systems; bioactive encapsulation; interfacial rheology; molecular modelling
(This special issue belongs to the Section Molecular Biophysics)
The Dynamic Membrane State: From Lipid Composition and Biophysical Organization to Cellular Function
edited by Marco Cavaglià
submission deadline 31 Mar 2027 | Viewed by 9 | Submission Open
Keywords: membrane lipids; membrane biophysics; lipidomics; lipid–protein interactions; membrane asymmetry; organelle membranes; lipid divide; bioelectricity; molecular dynamics; synthetic membranes
(This special issue belongs to the Section Molecular Biophysics)
Molecular Advances in Therapeutic Cancer Vaccines and Combination Immunotherapy
edited by Praveen Neeli
submission deadline 31 Mar 2027 | Viewed by 8 | Submission Open
Keywords: therapeutic cancer vaccines; neoantigens; DNA and mRNA vaccines; nanoparticle delivery; antigen presentation; tumor immune microenvironment; immune-checkpoint blockade; combination immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Identification, Mechanism of Action, and Applications of Bioactive Molecules from Natural Source
edited by
submission deadline 31 Mar 2027 | Viewed by 7 | Submission Open
Keywords: natural products; phytochemistry; mechanisms of action; molecular docking; metabolomics; biological activity; pharmacological applications; green extraction; nutraceuticals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Precision Construction, Molecular Dynamics and Functional Applications of Mechanically Interlocked Molecules
edited by and Li Wang
submission deadline 31 Mar 2027 | Viewed by 6 | Submission Open
Keywords: mechanically interlocked molecules; rotaxanes; catenanes; precision molecular construction; molecular dynamics; molecular machines; stimuli-responsive systems; functional applications
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Immune and Inflammatory Underpinnings of Neurodevelopmental and Neuropsychiatric Disorders submission deadline 31 Mar 2027 | Viewed by 6 | Submission Open
Keywords: neurodevelopmental disorders; neuroinflammation; PANS; neuroimmunology; pathogenetic pathways; autism spectrum disorder; attention deficit/hyperactivity disorder; tourette’s disorder; microglia; cytokines; autoimmunity; immunogenetics
(This special issue belongs to the Section Molecular Neurobiology)
Cardiovascular Diseases: Molecular Mechanisms of Cardiac Injury and Remodeling submission deadline 31 Mar 2027 | Viewed by 5 | Submission Open
Keywords: cardiovascular disease; cardiac injury; cardiac remodeling; heart failure; fibrosis; inflammation; noncoding RNAs; omics; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Structural Virology and Immunology of Respiratory Viruses
edited by
submission deadline 31 Mar 2027 | Viewed by 5 | Submission Open
Keywords: respiratory viruses; structural virology; structural immunology; vaccinology; viral proteins; virus–host interaction; cryogenic electron microscopy; X-ray crystallography; nuclear magnetic resonance
(This special issue belongs to the Section Molecular Microbiology)
Thyroid Biology and Thyroid Diseases: Advances in Molecular Theranostics
edited by and Anca Avram
submission deadline 31 Mar 2027 | Viewed by 4 | Submission Open
Keywords: thyroid biology; thyroid diseases; molecular theranostics; differentiated thyroid carcinoma; radioiodine therapy; SPECT/CT; PET/CT; molecular imaging; targeted radionuclide therapy; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Neurodevelopmental Disorders
edited by Rossella Suriano
submission deadline 31 Mar 2027 | Viewed by 3 | Submission Open
Keywords: neurodevelopmental disorders; autism spectrum disorder; ADHD; intellectual disability; molecular mechanisms; synaptic dysfunction; neurogenetics; epigenetics; mTOR signaling; brain organoids
(This special issue belongs to the Section Molecular Neurobiology)
Genomics and Functional Traits of Probiotic and Beneficial Microorganismstics
edited by Klaudia Gustaw and
submission deadline 31 Mar 2027 | Viewed by 2 | Submission Open
Keywords: probiotics; beneficial microorganisms; lactic acid bacteria; microbial genomics; whole-genome sequencing (WGS); comparative genomics; pangenomics; functional genomics; genotype–phenotype relationships; host–microbe interactions
(This special issue belongs to the Section Molecular Microbiology)
Advanced Research on Biomarkers and Treatments for Animal Diseases
edited by Maria Leonor Delgado
submission deadline 31 Mar 2027 | Submission Open
Keywords: animal diseases; veterinary medicine; biomarkers; diagnostic biomarkers; prognostic biomarkers; predictive biomarkers; molecular biomarkers; disease progression; therapeutic targets; novel therapies; treatment response; precision veterinary medicine; companion animals; molecular mechanisms; One Health
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Precise Molecular Biomarkers and Advanced Data Interpretation for Disease Diagnosis in Precision Laboratory Medicine
edited by and Mustafa K. Özçürümez
submission deadline 31 Mar 2027 | Submission Open
Keywords: precision medicine; reference intervals; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbial Modulation in Human Immune and Metabolic Systems: Emerging Mechanisms and Translational Opportunities
edited by
submission deadline 1 Apr 2027 | Viewed by 182 | Submission Open
Keywords: host–microbe interactions; immune regulation; metabolic homeostasis; microbial metabolites; dysbiosis; microbiome interventions; translational microbiology
(This special issue belongs to the Section Molecular Microbiology)
State-of-the-Art "Biochemistry" in Poland submission deadline 14 Apr 2027 | Viewed by 11 | Submission Open
Keywords: biochemistry; molecular biology; Polish science; enzymology; proteomics; metabolomics; lipidomics; genomics; genetics; transcriptomics; molecular medicine; biomarkers; drug discovery; bioactive compounds; systems biology; biotechnology; synthetic biology; protein structure and function; protein synthesis; membrane proteins; nucleic acids; DNA; RNA; transcription; translation; signal transduction; biomolecular interactions; cell–cell interactions; structure biology; membrane transport; analytical biochemistry; nano-biology; omics technologies; translational research; data analysis; amino acids; enzymes; cell signalling
(This special issue belongs to the Section Biochemistry)
Plant–Microbe Interactions: 2nd Edition
edited by Jian Jin
submission deadline 20 Apr 2027 | 6 articles | Viewed by 14912 | Submission Open
Keywords: plant; crop; rhizosphere microbiome; microbial colonization; quorum sensing; endophytic microbes
(This special issue belongs to the Section Molecular Plant Sciences)
Anti-Cancer Drugs: Natural Products, Synthetic Compounds and Potential Pharmacological Effects and Applications
edited by Kaiqun Ren and Hui Zou
submission deadline 20 Apr 2027 | 4 articles | Viewed by 14202 | Submission Open
Keywords: cancer; natural product; synthetic compounds; mechanism; structural modification; pharmacological action
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Imaging for Cancer Theranostics
edited by and Kai Bao
submission deadline 20 Apr 2027 | 3 articles | Viewed by 8348 | Submission Open
Keywords: molecular imaging; cancer theranostics; precision medicine; targeted therapy; diagnostic imaging; theranostic agents; multimodal imaging; molecular probes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomaterials and Antibacterial Materials for Medical Applications
edited by
submission deadline 20 Apr 2027 | 2 articles | Viewed by 2153 | Submission Open
Keywords: biomaterial science; photodynamic antibacterial materials; photothermal antibacterial materials; advanced antibacterial materials; antimicrobial nanostructured materials; polymer-based biomaterials; infected wound dressings
(This special issue belongs to the Section Materials Science)
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