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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Network Pharmacology: An Emerging Field in Drug Discovery (2nd Edition)

edited by

Weiwei Han

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2004 | Submission Open

Keywords: network pharmacology; machine learning; databases; drug discovery; computer-aided drug design (CADD); data mining

(This special issue belongs to the Section Molecular Pharmacology)

Liquid Biopsies in Oncology—3rd Edition

edited by

Sandra V. Fernandez

and

Carmela Paolillo

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1668 | Submission Open

Keywords: precision oncology; personalized therapy; cancer biomarkers; liquid biopsy; biological fluids; circulating molecules; circulating tumor cells; CTCs; ctDNA; ctRNA; cell-free DNA; cfDNA; NGS; circulating miRNAs; exosomes; extracellular vesicles

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Reproduction and Fertility of Aquatic Animals: 3rd Edition

edited by

Hui Qiao

and Hongtuo Fu

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1612 | Submission Open

Keywords: reproduction; aquatic animals; sex determination; gonadal development; steroid hormones; sex-related genes; monosex culture

(This special issue belongs to the Section Molecular Biology)

Microbiomes in Human Health and Disease

edited by

Andreas Burkovski

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1606 | Submission Open

Keywords: microbiome; dysbiosis; commensal bacteria; pathobiont; metabolites; immune modulation; nutrient metabolism; barrier function; health and disease

(This special issue belongs to the Section Molecular Microbiology)

Viral Infections: Physiology, Pathophysiology, Pathogenesis, Diagnosis and Treatment, 2nd Edition

edited by

Barbara Bażanów

and Dominika Marta Stygar

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1566 | Submission Open

Keywords: viral infections; virus mutations; molecular diagnostic methods; antiviral drugs/preparations; viral diseases; physiological mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Innovative Technologies in the Study and Understanding of Colorectal Tumorigenesis: Challenges and Opportunities

edited by

Paola Sena

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1250 | Submission Open

Keywords: colorectal cancer; genetic analysis; gut microbiome; tumor; circulating components; medicine; immunotherapy; proteomics

(This special issue belongs to the Section Molecular Oncology)

Melanoma: Molecular Diagnosis and Treatment

edited by

Teresa Lettini

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1175 | Submission Open

Keywords: molecular pathology; melanoma; skin cancer; molecular pathway; dermatopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Damage to Plants and Microorganisms Caused by Heavy Metal Toxicity

edited by

Xiaomeng Chen

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1148 | Submission Open

Keywords: metal; oxidative stress; stress response; molecular function; gene regulation; metabolic regulation; signaling pathway

(This special issue belongs to the Section Molecular Plant Sciences)

Genetic Advances in Neurobiology of Health and Disease

edited by

Efthimios M. C. Skoulakis

and Katerina Papanikolopoulou

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1073 | Submission Open

Keywords: genomics; proteins; proteomics; signaling

(This special issue belongs to the Section Molecular Neurobiology)

Oral Diseases: Molecular Research and Novel Therapy

edited by

I-Ta Lee

submission deadline 28 Feb 2026 | Viewed by 1071 | Submission Open

Keywords: oral diseases; molecular mechanisms; inflammation and immunity; redox signalling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Trends and Future Directions in Antimicrobial Peptide Research

edited by

Sara Elsa Aita

submission deadline 28 Feb 2026 | 1 articles | Viewed by 933 | Submission Open

Keywords: antimicrobial peptides (AMPs); host defense; structure-function; antimicrobial agents; biomedical applications; antibiotic alternatives; antibiotic resistance

(This special issue belongs to the Section Molecular Biology)

Molecular Biology of Foodborne Pathogens: Genomics, Resistance, and New Perspectives

edited by

Joanna Gajewska

submission deadline 28 Feb 2026 | Viewed by 916 | Submission Open

Keywords: foodborne pathogens; antibiotic resistance; virulence factor; virulence genes; gene expression; bioinformatics; whole geomic sequencing

(This special issue belongs to the Section Molecular Microbiology)

New Advances in Amyotrophic Lateral Sclerosis

edited by

Vacchiano Veria

submission deadline 28 Feb 2026 | 1 articles | Viewed by 841 | Submission Open

Keywords: genetics and epigenetics; biomarkers; nutrition and metabolism; TDP-43 pathology; advanced model of ALS

(This special issue belongs to the Section Molecular Neurobiology)

Cardiovascular and Metabolic Pharmacology

edited by

Alma Martelli

submission deadline 28 Feb 2026 | 1 articles | Viewed by 830 | Submission Open

Keywords: cardiovascular pharmacology; metabolic pharmacology; hypertension; diabetes; obesity; atherosclerosis; hyperlipidemias; heart failure

(This special issue belongs to the Section Molecular Pharmacology)

New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 4th Edition

edited by

Yutang Wang

and

Dianna Magliano

submission deadline 28 Feb 2026 | 1 articles | Viewed by 805 | Submission Open

Keywords: cardiovascular disease; myocardial infarction; stroke; transient ischemic attack; hypertension; diabetes mellitus; atherosclerosis; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances and Views in Triple-Negative Breast Cancer

edited by

Ioannis Boutas

submission deadline 28 Feb 2026 | 1 articles | Viewed by 795 | Submission Open

Keywords: breast cancer; molecular biology; personalized medicine; triple-negative breast cancer

(This special issue belongs to the Section Molecular Oncology)

Advances in Natural Antioxidants in Human Health and Diseases

edited by

Eman M. Othman

submission deadline 28 Feb 2026 | 1 articles | Viewed by 778 | Submission Open

Keywords: oxidative stress and diseases; antioxidants; natural products

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Diagnostics and Therapeutic Targets in Bladder Cancer (Second Edition)

edited by

Hideki Furuya

submission deadline 28 Feb 2026 | 1 articles | Viewed by 713 | Submission Open

Keywords: non-muscle invasive bladder cancer; muscle-invasive bladder cancer; metastatic bladder cancer; diagnostic biomarkers; therapeutic targets; early detection; progression biomarkers; liquid biopsy; genomic profiling; proteomics; metabolomics; imaging biomarkers; multi-omics; targeted therapy; immunotherapy; antibody– drug conjugates; DNA damage response; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunity in Neurodegenerative Diseases: Systemic Immune Imbalance, Neuroinflammation, and Beyond—2nd Edition

edited by

Ivana Munitic

submission deadline 28 Feb 2026 | 1 articles | Viewed by 683 | Submission Open

Keywords: neurodegeneration; CNS immunosurveillance; neuroinflammation; neuroimmune axis; glia; T cells; phagocytosis; immunomodulation; autoimmunity; immunodeficiency

(This special issue belongs to the Section Molecular Neurobiology)

The Differential Role of B Cells in Autoimmune Diseases: From Autoantibodies to Antigen Presentation

edited by

Markus C. Kowarik

submission deadline 28 Feb 2026 | 1 articles | Viewed by 672 | Submission Open

Keywords: autoantibodies; B cells; antigen presentation; B cell functions; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

New Insights into Network Pharmacology

edited by

Mi Hye Kim

submission deadline 28 Feb 2026 | 1 articles | Viewed by 644 | Submission Open

Keywords: network pharmacology; traditional medicine; drug discovery; computational biology; molecular mechanisms; protein– protein interaction; enrichment analysis; herb– compound– gene network

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Molecular Biomarkers in Cancer and Metabolic Diseases

edited by

José Antonio Morales-González

and

Angel Morales-González

submission deadline 28 Feb 2026 | 1 articles | Viewed by 625 | Submission Open

Keywords: biomarkers; cancer; metabolic disease; diagnosis; prognosis; treatment

(This special issue belongs to the Section Molecular Biology)

Marine Natural Products as a Source of Therapeutics—Recent Trends

edited by

Komal Anjum

submission deadline 28 Feb 2026 | 1 articles | Viewed by 578 | Submission Open

Keywords: marine natural products; marine-associated microbes; antimicrobial drug; antibiotics; marine-derived peptides; anti-inflammatory; molecular pharmacology; targeted therapies; extraction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Cellular Biology of Germ Cells

edited by

Anna Tabęcka-Łonczyńska

submission deadline 28 Feb 2026 | 1 articles | Viewed by 552 | Submission Open

Keywords: germ cell development; meiosis; epigenetic regulation; autophagy; mitochondrial dynamics; infertility; reproductive medicine; germ cell tumors; steroidogenesis; endocrine disrupting chemicals; reproductive toxicity

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Heart Disease: Genomics and Bioinformatics of Heart Research—2nd Edition

edited by Justyna Fert-Bober

submission deadline 28 Feb 2026 | 1 articles | Viewed by 422 | Submission Open

Keywords: heart disease; cardiovascular disease; coronary artery disease (CAD); heart attack; heart failure; arrhythmia (abnormal heart rhythms); valve disease; high blood pressure; congenital heart conditions; inherited heart conditions; fibrosis; pathobiology of fibrosis; aging; chronic inflammation; inflammatory and cardiovascular diseases; myocarditis; extracellular matrix biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Integrins in Cytokine Signaling

edited by

Yoshikazu Takada

submission deadline 28 Feb 2026 | 1 articles | Viewed by 368 | Submission Open

Keywords: integrins; cytokines; FGF1; CX3CL1; ternary-complex; antagonist; inside-out signaling; integrin-binding motif; cytokine-integrin crosstalk; ligand-induced activation

(This special issue belongs to the Section Molecular Biology)

Advances in Plant Protein and Enzyme Inhibitors

edited by Yan Zhang

submission deadline 28 Feb 2026 | Viewed by 345 | Submission Open

Keywords: plant proteins; active substances; bioactive compounds; enzyme inhibitors

(This special issue belongs to the Section Molecular Plant Sciences)

Bridging Molecules and Reactions: Next-Generation Approaches for Advancing Electrocatalytic Efficiency

edited by

Abu Talha Aqueel Ahmed

submission deadline 28 Feb 2026 | 1 articles | Viewed by 328 | Submission Open

Keywords: electrochemical nanomaterials; energy storage and conversion; electrocatalysis and reaction mechanisms; photoelectrochemical water splitting; electrochemical energy storage devices; nanocomposites and functionalized materials; molecular-level electrocatalysis; electrocatalyst and photocatalysts; in-situ spectroscopy and atomistic modeling; hybrid molecular– nanostructured systems; sustainable and natural resource– derived materials; DFT related to reaction kinetics; AOP

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Metabolic Syndrome: New Insights in Pathogenesis, Diagnosis, Prevention, and Management—2nd Edition

edited by

Lucia Maria Procopciuc

and

Roxana Liana Lucaciu

submission deadline 28 Feb 2026 | 1 articles | Viewed by 317 | Submission Open

Keywords: insulin resistance; hypertension; diabetes mellitus; obesity; inflammation; stress; metabolic disorders; reproductive endocrine disorders; polycystic ovarian syndrome; waist circumference; estrogen deficiency; disturbances in adipose tissue; physical inactivity; overnutrition; cardiovascular diseases; abdominal obesity; genetics and epigenetics of metabolic syndrome; computational analysis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Schiff Bases and Their Metal Complexes: Structure, Synthesis, and Biological Application

edited by Nenad Filipovic

submission deadline 28 Feb 2026 | Viewed by 309 | Submission Open

Keywords: hydrazones; (thio/seleno)semicarbazones; oximes; antimicrobial activity; anticancer activity; enzyme inhibition; metal complexes; diagnostic agents; photothermal therapy; photodynamic therapy

(This special issue belongs to the Section Biochemistry)

Pathophysiology and Molecular Mechanisms of Cardiovascular, Cardiometabolic, and Cardiorenal Diseases

edited by

Carmine Savoia

submission deadline 28 Feb 2026 | 1 articles | Viewed by 294 | Submission Open

Keywords: heart failure; cardiorenal syndrome; oxidative stress; inflammation; endothelial dysfunction; fibrosis and remodeling; mitochondrial function and energy metabolism; insulin resistance; epigenetics and microRNAs; biomarkers and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Toxicity Caused by Environmental Pollutants

edited by Ivan Girón-Perez

submission deadline 28 Feb 2026 | 1 articles | Viewed by 253 | Submission Open

Keywords: environmental pollutant; molecular toxicity; immunotoxicology; neurotoxicity

(This special issue belongs to the Section Molecular Toxicology)

Environmental Exposures and Chronic Obstructive Pulmonary Disease Pathogenesis

edited by

Abderrazzak Bentaher

submission deadline 28 Feb 2026 | Viewed by 252 | Submission Open

Keywords: chronic obstructive pulmonary disease; environmental exposures; disease pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials and Antibacterial Materials for Medical Applications

edited by

Shixiong Yi

submission deadline 28 Feb 2026 | Viewed by 224 | Submission Open

Keywords: biomaterial science; photodynamic antibacterial materials; photothermal antibacterial materials; advanced antibacterial materials; antimicrobial nanostructured materials; polymer-based biomaterials; infected wound dressings

(This special issue belongs to the Section Materials Science)

Exploring Molecular Insights in Oral Health and Disease

edited by

Iulia-Ioana Stanescu-Spinu

and

Tudor Claudiu Spînu

submission deadline 28 Feb 2026 | Viewed by 222 | Submission Open

Keywords: oral health; saliva; oral diseases; molecular insights; molecular targets; oral cavity physiology; wound healing; oral microbiome; oral biocompatibility; material interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Regenerative and Anti-Aging Medicine

edited by

Takayuki Yoshimoto

submission deadline 28 Feb 2026 | Viewed by 178 | Submission Open

Keywords: induced pluripotent stem cells (iPSCs); mesenchymal stem cells (MSCs); platelet-rich plasma (PRP); placenta; organoid; secretome; exosome; senolytics; nicotinamide mononucleotide (NMN); nicotinamide adenine dinucleotide+ (NAD+)

(This special issue belongs to the Section Molecular Biology)

New Progress in Peptidic Protease Inhibitors

edited by

Roberta Ettari

and Carla Di Chio

submission deadline 28 Feb 2026 | Viewed by 176 | Submission Open

Keywords: peptide inhibitors; infectious diseases; cancer; metabolic disorders; neurological disorders; inflammation

(This special issue belongs to the Section Biochemistry)

Strategies for Enhancing Skeletal Muscle Recovery and Regeneration in Health and Disease Conditions

edited by

Elen Miyabara

and

Atsushi Asakura

submission deadline 28 Feb 2026 | Viewed by 174 | Submission Open

Keywords: skeletal muscle; regeneration; muscle wasting; aging; muscle diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biosynthesis and Regulatory Mechanism of Secondary Metabolites in Medicinal Plants: 3rd Edition

edited by

Shanfa Lu

submission deadline 28 Feb 2026 | Viewed by 167 | Submission Open

Keywords: biosynthetic pathway; epigenetic regulation; high-throughput sequencing; medicinal plant; metabolic engineering; omics; regulatory mechanism; secondary metabolite; synthetic biology; transcription factor

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Dietary Polyphenols and Dietary Polysaccharides in Human Diseases

edited by

Francisco Les

submission deadline 28 Feb 2026 | Viewed by 167 | Submission Open

Keywords: dietary polyphenols; dietary polysaccharides; bioactive compounds; chronic diseases prevention; functional foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Imprinting Technologies for Biological and Biomedical Applications

edited by

Urtė Prentice

and

Simonas Ramanavičius

submission deadline 28 Feb 2026 | Viewed by 160 | Submission Open

Keywords: molecularly imprinted polymers; biosensors and diagnostics; biomolecular recognition; molecular imprinting; nanomaterials; molecular biology applications

(This special issue belongs to the Section Molecular Informatics)

Abnormal Production and Structure of Hemoglobin Molecules

edited by Maria Dimopoulou

submission deadline 28 Feb 2026 | Viewed by 159 | Submission Open

Keywords: hemoglobin; hemoglobinopathies; thalassemias; sickle cell disease; structural hemoglobin variants; alpha globin; beta globin; globin chain genes; unstable hemoglobins; oxygen affinity

(This special issue belongs to the Section Biochemistry)

Interactions and Functions Between Peptides and Polysaccharides

edited by

Kexue Zhu

and

Xianxiang Chen

submission deadline 28 Feb 2026 | Viewed by 156 | Submission Open

Keywords: polysaccharides; peptides; bioactivity; structural analysis; polysaccharide– peptide complexes; interactions; gut microbiota; immune regulation; interaction dynamics

(This special issue belongs to the Section Biochemistry)

Role of Extracellular Vesicles in Immune Regulation

edited by Rachel Crossland

submission deadline 28 Feb 2026 | Viewed by 153 | Submission Open

Keywords: extracellular vesicle; immune regulation; immunomodulation; antigen presentation; inflammation; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Oxidative-Stress in Human Health and Diseases

edited by

Ramoji Kosuru

submission deadline 28 Feb 2026 | Viewed by 149 | Submission Open

Keywords: oxidative stress; ROS; redox signaling; metabolic adaptation; oxidative homeostasis; endothelial dysfunction

(This special issue belongs to the Section Biochemistry)

Biomaterials: From Design, Synthesis and Characterization to Application—2nd Edition

edited by

Tao Sun

and

Xujin Bao

submission deadline 28 Feb 2026 | Viewed by 145 | Submission Open

Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis

(This special issue belongs to the Section Materials Science)

Molecular Mechanism in Cardiac Remodeling

edited by Xianming Lin and

Xiaobo Wu

submission deadline 28 Feb 2026 | Viewed by 140 | Submission Open

Keywords: cardiomyopathy; cardiac arrhythmias; ion channel; calcium transient

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Functionalization of Biopolymers and Bio-Oligomers for Precision Therapeutics

edited by

Dayong Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 139 | Submission Open

Keywords: precision therapeutics; biopolymers; drug delivery; biopharmaceuticals; pharmacology

(This special issue belongs to the Section Materials Science)

Using Model Organisms to Study Complex Human Diseases—2nd Edition

edited by

Roberto Piergentili

submission deadline 28 Feb 2026 | Viewed by 132 | Submission Open

Keywords: model organism; Escherichia coli; yeast; Caenorhabditis elegans; Drosophila melanogaster; zebrafish; Arabidopsis thaliana; Xenopus laevis; rat and mouse model; human disease; inherited disease; cancer; rare disease; genetics

(This special issue belongs to the Section Molecular Biology)

Neurofibromatosis Type 1 and NF2-Related Schwannomatosis: Advances from Basic Research to Current Therapies

edited by

Bumjoon Park

and

Baehoon Kim

submission deadline 28 Feb 2026 | Viewed by 129 | Submission Open

Keywords: neurofibromatosis type 1 (NF1); neurofibromin; RAS/MAPK pathway; malignant peripheral nerve sheath tumor (MPNST); NF2-related schwannomatosis (NF2 syndrome); Merlin (Schwannomin); vestibular schwannoma; meningioma; ependymoma

(This special issue belongs to the Section Molecular Neurobiology)

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