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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immunotherapies of Solid Tumors

edited by

Steven Fiering

submission deadline 31 Dec 2026 | Viewed by 372 | Submission Open

Keywords: immune; solid tumors; anti-tumor; molecular pathways; immunotherapy; tumor microenvironment; checkpoint; CAR T cell; adoptive cell

(This special issue belongs to the Section Molecular Immunology)

Pancreatic Cancer: Biomarkers and New Drug Development

edited by Yi-Ming Arthur Chen

submission deadline 31 Dec 2026 | Viewed by 370 | Submission Open

Keywords: pancreatic ductal adenocarcinoma; biomarkers; transcriptomic subtypes; new drug development; target therapy; immunotherapy; KRAS inhibitors; precision medicine; health supplements

(This special issue belongs to the Section Molecular Oncology)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Adipose Tissue–Liver Crosstalk: Mechanisms and Therapeutic Opportunities

edited by Lei Hao

submission deadline 31 Dec 2026 | 1 articles | Viewed by 367 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); adipose tissue–liver crosstalk; brown adipose tissue (BAT); beige adipocytes; white adipose tissue (WAT); thermogenesis; adipokines; hepatokines; energy metabolism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Applications of Machine Learning and Chemoinformatics in Molecular Prediction and Drug Discovery

edited by Saurav Mallik

submission deadline 31 Dec 2026 | Viewed by 362 | Submission Open

Keywords: drug discovery; epigenetics; immunology; cancer biology; aging; graph mining; neural network; structural biology

(This special issue belongs to the Section Molecular Informatics)

Unraveling Affective Disorders: From Pathogenesis to Drug Therapy

edited by Lawrence Shih-Hsin Wu

submission deadline 31 Dec 2026 | Viewed by 359 | Submission Open

Keywords: affective disorders; depressive disorder; bipolar disorder; neuroinflammation; neurotransmitter dysregulation; gene–environment interactions; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Immunology in Health and Disease

edited by

Adli Ali

submission deadline 31 Dec 2026 | 1 articles | Viewed by 350 | Submission Open

Keywords: immunodeficiencies; autoimmunity; inflammation; immunometabolism; neuroinflammation; immunotherapy; immunophenotyping; biomarkers; infection; precision medicine; immunogenetics

(This special issue belongs to the Section Molecular Immunology)

Genetic and Metabolic Liver Disorders: Advances in Diagnosis, Disease Mechanisms and Treatment

edited by

Francesco Callea

and

Emanuele Agolini

submission deadline 31 Dec 2026 | Viewed by 326 | Submission Open

Keywords: genetic liver disease; metabolic disorders; disease mechanisms; genotype–phenotype correlation; compound heterozygosity; pathogenetic mutations; VUS mutations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Multi-Omics in Fruit Quality Development and Sustainability

edited by

Kaibing Zhou

submission deadline 31 Dec 2026 | Viewed by 325 | Submission Open

Keywords: transcriptome; proteome; metabolome; fruit appearance quality; fruit nutrient and taste quality; post-harvest storage; biotic and abiotic stress; identification and evaluation of fruit germplasm; horticultural technique of artificial intelligence

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of SARS-CoV-2 in Immunomodulation—Post-Pandemic Reflection on the Role of Viruses in Human Immunology: 2nd Edition

edited by

Katarzyna A. Lisowska

submission deadline 31 Dec 2026 | Viewed by 311 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immunomodulation; T cells; B cells; dendritic cells; monocytes; cytokines

(This special issue belongs to the Section Molecular Immunology)

Neutrophils in Human and Animal Reproduction: Functions, Disorders, and Therapeutic Potential

edited by

Fabiola Zambrano

submission deadline 31 Dec 2026 | 1 articles | Viewed by 311 | Submission Open

Keywords: neutrophils; reproductive immunology; NETosis; extracellular traps; fertility; reproductive disorders; endometritis; male infertility; reproductive tract infections; oxidative stress

(This special issue belongs to the Section Molecular Immunology)

Functional Activities of Natural Products

edited by

Loh Yean Chun

submission deadline 31 Dec 2026 | Viewed by 288 | Submission Open

Keywords: phytochemicals; biological products; pharmacological actions; plant extracts; structural-activity; functional foods; well-being

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Idiosyncratic Drug Induced Liver Injury

edited by

Rolf Teschke

submission deadline 31 Dec 2026 | Viewed by 288 | Submission Open

Keywords: updated RUCAM; iDILI; immune iDILI; autoimmune iDILI; classic idiosyncratic DILI (iDILI); drug-induced autoimmune hepatitis (DIAIH); idiosyncratic drug-induced anti-CYP autoimmune hepatitis; HLA-based immune iDILI; immune iDILI with SJS/TEN; immune iDILI by ICIs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Trends and Prospects in Biomaterials

edited by Gabriela Graziani and

Daniele Ghezzi

submission deadline 31 Dec 2026 | Viewed by 276 | Submission Open

Keywords: biomaterials; orthopaedics; wound healing; additive manufacturing; infection; tissue modelling; tissue regeneration; orthopaedics; wound healing; antibacterial materials; regenerative medicine; reparative medicine

(This special issue belongs to the Section Materials Science)

Leishmaniasis: Pathogenesis and Emerging Therapeutic Strategies

edited by

Mariana M. Chaves

submission deadline 31 Dec 2026 | Viewed by 255 | Submission Open

Keywords: leishmaniasis; host–parasite; immune regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in tRNA Research and Therapeutics

edited by

Constantinos Stathopoulos

, Michael Ibba,

Jinwei Zhang

and

Vassiliki Stamatopoulou

submission deadline 31 Dec 2026 | Viewed by 251 | Submission Open

Keywords: tRNA; genetic code; RNA therapies; transcription; translation; RNA-mediated regulation

(This special issue belongs to the Section Molecular Biology)

Molecular Structure and Functional Dynamics of Bacterial Toxins in Pathogenesis and Biomedical Innovation

edited by

Chanan Angsuthanasombat

and Aijaz Malik

submission deadline 31 Dec 2026 | Viewed by 250 | Submission Open

Keywords: bacterial toxins; structural biology; host–pathogen interactions; toxin mechanisms; protein engineering; immunotoxins; synthetic biology; antimicrobial strategies; drug delivery; translational research

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Plant–Soil–Water Interactions in Agricultural Systems

edited by

Hassan Iqbal

submission deadline 31 Dec 2026 | 1 articles | Viewed by 238 | Submission Open

Keywords: plant–soil–water interactions; agricultural systems; drought stress; salinity stress; waterlogging; aquaporins; root architecture; rhizosphere; molecular signaling; multi-omics

(This special issue belongs to the Section Molecular Plant Sciences)

Deep Learning-Driven Drug Discovery

edited by

Bowei Zhao

submission deadline 31 Dec 2026 | Viewed by 234 | Submission Open

Keywords: deep learning; drug discovery; AI-driven drug design; molecular interactions; compound optimi-zation; virtual screening; biomarker discovery; drug repurposing; multi-omics integration; toxicity prediction

(This special issue belongs to the Section Molecular Informatics)

Soil Nutrient Cycling and Microbial Driving Mechanisms

edited by

Mohsin Mahmood

submission deadline 31 Dec 2026 | Viewed by 233 | Submission Open

Keywords: soil nutrient cycling; microbial driving mechanisms; soil–plant–microbe interactions; carbon, nitrogen, and phosphorus dynamics; soil biogeochemistry; microbial communities and functions; rhizosphere processes; climate change impacts on soils; sustainable nutrient management; biochar and nanotechnology applications; soil health and fertility; biogeochemical transformations; stress environments (salinity, drought, contamination)

(This special issue belongs to the Section Molecular Microbiology)

Transformative Computational and AI Approaches for Precision Drug Discovery

edited by Danishuddin and

Md Azizul Haque

submission deadline 31 Dec 2026 | Viewed by 229 | Submission Open

Keywords: precision drug discovery; AI-driven drug design; computational drug discovery; molecular docking and simulation; machine learning and deep learning; multi-omics integration; ADME/toxicity prediction; network pharmacology; precision medicine and therapeutics; bioinformatics

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms of Neurodevelopment, Neuroprotection, and Brain Health

edited by

Ramón Iglesias-Rey

submission deadline 31 Dec 2026 | Viewed by 221 | Submission Open

Keywords: cerebral ischemia; neurovascular coupling; brain plasticity; endothelial dysfunction; neu-roinflammation; tissue repair; imaging biomarkers; stroke recovery; molecular neurobiology; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Dietary Modulation of the Gut Microbiome: Functional Additives and Their Role in Health and Disease

edited by

Wageha Awad

submission deadline 31 Dec 2026 | Viewed by 216 | Submission Open

Keywords: gut microbiota; gut health; dietary modulation; functional additives: probiotics, prebiotics and postbiotics; infection; animal production; poultry; microbial metabolites

(This special issue belongs to the Section Molecular Microbiology)

Molecular Pathogenesis of Common Pregnancy Complications

edited by Radzisław Mierzyñski and

Elżbieta Poniedziałek-Czajkowska

submission deadline 31 Dec 2026 | Viewed by 216 | Submission Open

Keywords: pregnancy complications; maternal and fetal health; preterm delivery; intra-amniotic infection; hypertensive disorders; metabolic syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Ocular Inflammation and Infection

edited by Kofi Asiedu

submission deadline 31 Dec 2026 | Viewed by 207 | Submission Open

Keywords: ocular inflammation; corneal infection; neuroimmunology; immune–nerve interactions; ocular surface disease; cytokines and chemokines; molecular biomarkers; in vivo confocal microscopy

(This special issue belongs to the Section Molecular Immunology)

Platelet-Based Biomaterials in Regenerative Medicine: Biochemical Insights and Therapeutic Perspectives

edited by

Vincenzo Vestuto

Maria Pia Pasolini

and Maria Rosaria Miranda

submission deadline 31 Dec 2026 | Viewed by 204 | Submission Open

Keywords: PRP; PRF; platelet-based biomaterials; regenerative medicine; tissue regeneration; biochemical pathways; biomaterials; translational medicine; clinical biochemistry

(This special issue belongs to the Section Biochemistry)

Advances in Parasite Biology: Molecular Mechanisms, Host Interactions and Antiparasitic Strategies

edited by

Dandan Hu

submission deadline 31 Dec 2026 | Viewed by 203 | Submission Open

Keywords: parasite biology; host–parasite interactions; antiparasitic strategies; antiparasitic drugs; drug resistance; vaccine development; molecular parasitology; immune evasion; one health

(This special issue belongs to the Section Molecular Biology)

Advances in Polymer Electrochemical Materials

edited by He Zhang,

Xiangliang Zeng

and Cao Ge

submission deadline 31 Dec 2026 | Viewed by 191 | Submission Open

Keywords: polymer electrochemical materials; flexible electronics; electrochromic devices; bioelectronics; corrosion protection; supercapacitors; batteries; biomaterials; conducting polymers; energy storage

(This special issue belongs to the Section Materials Science)

Pharmacological Advances of Epilepsy

edited by

Noemí Cárdenas-Rodríguez

Cindy Bandala

and Iván Ignacio-Mejía

submission deadline 31 Dec 2026 | 1 articles | Viewed by 188 | Submission Open

Keywords: epilepsy; antiseizure medications; pharmacology; epileptogenesis; drug resistance epilepsy; neuroinflammation; pharmacogenomics; oxidative stress; molecular targets; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Green Synthesis of Nanomaterials: Cytotoxicity and Drug Delivery

edited by

Mustafa Cengiz

submission deadline 31 Dec 2026 | Viewed by 187 | Submission Open

Keywords: green synthesis; green-nanomaterials; cytotoxicity; antibacterial activity; drug delivery; biocompatibility; anticancer activity; oxidative stress

(This special issue belongs to the Section Molecular Nanoscience)

Plants and Their Compounds in Drug Design: Molecule to Molecular Dynamics Simulation

edited by

Thaigarajan Parumasivam

and

Ramlal Ayyagari

submission deadline 31 Dec 2026 | Viewed by 187 | Submission Open

Keywords: phytochemicals; computer-aided drug design; molecular docking; molecular dynamics simulation; virtual screening; ADMET profiling; network pharmacology; natural products

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Coordination Chemistry: Thermodynamic, Spectroscopic, and Biological Insights

edited by Michał Zabiszak

submission deadline 31 Dec 2026 | Viewed by 185 | Submission Open

Keywords: coordination chemistry; metal–ligand interactions; thermodynamic studies; spectroscopic characterisation; bioinorganic chemistry; supramolecular chemistry; medicinal inorganic chemistry; biological activity

(This special issue belongs to the Section Biochemistry)

The Importance of Circadian Toxicology in Human Lifestyle Diseases

edited by

Edyta Reszka

submission deadline 31 Dec 2026 | Viewed by 181 | Submission Open

Keywords: circadian toxicology; chronotoxicity; phototoxicity; circadian rhythm; artificial light at night; melatonin; human lifestyle diseases

(This special issue belongs to the Section Molecular Toxicology)

Mechanisms of Pain Development and Treatment Strategies

edited by

Tomohiko Aoe

submission deadline 31 Dec 2026 | Viewed by 177 | Submission Open

Keywords: chronic pain; fibromyalgia; long COVID; post-viral fatigue/pain syndrome; neuropathic pain; neuroinflammation; stress responses; opioid tolerance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Evolution of Venom Peptides

edited by

Laura Valdez-Velazquez

submission deadline 31 Dec 2026 | Viewed by 173 | Submission Open

Keywords: venom peptides; molecular evolution; toxinology; venomics; bioactive compounds

(This special issue belongs to the Section Molecular Biology)

Bioactive Compounds from Food in Health and Diseases

edited by

Vanja M. Todorović

and

Nevena Dabetic

submission deadline 31 Dec 2026 | Viewed by 173 | Submission Open

Keywords: biological activity; antioxidants; nutraceuticals; polyphenols; redox balance; functional ingredients; dietary inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Progression of Genetics in Breeding of Farm Animals, 2nd Edition

edited by

Karel Novák

submission deadline 31 Dec 2026 | Viewed by 170 | Submission Open

Keywords: farm animal; livestock; genome sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Discovering Natural Products for Cancer

edited by

Wingshing Ho

submission deadline 31 Dec 2026 | Viewed by 168 | Submission Open

Keywords: natural products; receptors; drug development; genome; derivatives; cancer; drug target

(This special issue belongs to the Section Molecular Oncology)

Molecular, Metabolic, and Endocrine Mechanisms in Reproduction

edited by Aleksandra Stefanović

submission deadline 31 Dec 2026 | Viewed by 166 | Submission Open

Keywords: reproductive disorders; pregnancy complications; obesity; inflammation; oxidative stress

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Bioactive Phytochemicals of Plant Origins

edited by

Onur Ketenoglu

submission deadline 31 Dec 2026 | Viewed by 161 | Submission Open

Keywords: bioactivity; plant; phenolics; toxicity; health-promoting attributes; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Computational Genomics and AI in Human Disease Therapeutics

edited by

Talha Burak Alakus

submission deadline 31 Dec 2026 | Viewed by 159 | Submission Open

Keywords: computational genomics; artificial intelligence; human disease therapeutics; precision medicine; biomarker discovery; clinical prediction; translational bioinformatics; machine learning and deep learning

(This special issue belongs to the Section Molecular Informatics)

Fluorescent Probes for Cellular and Molecular Imaging

edited by

Ritika Gupta

submission deadline 31 Dec 2026 | Viewed by 158 | Submission Open

Keywords: fluorescent probes; molecular imaging; cellular imaging; live-cell imaging; biosensing; aptamer-based probes; antibody conjugates; super-resolution microscopy; biomarker detection; multiplex imaging; optical imaging

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics in Ovarian Cancer (2nd Edition)

edited by

Bruna Scaggiante

submission deadline 31 Dec 2026 | Viewed by 158 | Submission Open

Keywords: chemotherapy resistance; differential gene expression; genomic structural variation; ovarian cancer mutations; ovarian cancer metastasis; ovarian cancer treatment; novel molecular targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Updates on Pathogenesis and Molecular Targets of Alzheimer’s Disease

edited by Jean-Pierre Brion and Kunie Ando

submission deadline 31 Dec 2026 | Viewed by 156 | Submission Open

Keywords: Alzheimer’s disease; tau; amyloid; neurodegenerative diseases; inflammation; biomarkers; genetic variants; risk factors; protein-protein interactions; post-translational modifications

(This special issue belongs to the Section Molecular Neurobiology)

Natural Bioactive Compounds: Green Extraction and Applications

edited by Milica Atanacković Krstonošić

submission deadline 31 Dec 2026 | Viewed by 154 | Submission Open

Keywords: bioactive molecules; green extraction; spectrometry; chromatography; delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Products in Health and Diseases

edited by

Jinnatun Nahar

submission deadline 31 Dec 2026 | Viewed by 152 | Submission Open

Keywords: natural products; phytochemicals; bioactive compounds; molecular mechanisms; drug delivery; antioxidant activity; anti-inflammatory activity; antimicrobial resistance; cancer therapeutics; nanoformulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Biomaterial Advances in Tissue Engineering

edited by

Haishan Shi

and

Jinfeng He

submission deadline 31 Dec 2026 | Viewed by 149 | Submission Open

Keywords: tissue engineering; regenerative medicine; biomaterials; stem cells; 3D bioprinting; molecular mechanisms; extracellular matrix

(This special issue belongs to the Section Materials Science)

Cellular and Molecular Mechanisms of Exercise-Induced Tissue Adaptation in Health, Disease and Performance

edited by

Gilberto E. Shiguemoto

and

Wladimir Rafael Beck

submission deadline 31 Dec 2026 | Viewed by 149 | Submission Open

Keywords: skeletal muscle plasticity; exerkines and tissue crosstalk; molecular signaling pathways; exercise training adaptation; mitochondrial function; mitokines and metabolic crosstalk; epigenetic regulation; myokines

(This special issue belongs to the Section Molecular Biology)

Gut Microbiota in Disease Pathophysiology and Therapy

edited by

Dulcenombre Gómez Garre

submission deadline 31 Dec 2026 | Viewed by 149 | Submission Open

Keywords: gut microbiota; dysbiosis; microbial metabolites; host–microbiota interactions; microbiome-targeted therapy; fecal microbiota transplantation; probiotics and postbiotics; gut–brain axis; metabolic and immune-mediated diseases; personalized medicine

(This special issue belongs to the Section Molecular Microbiology)

Molecular Advances in Aquaculture Biology

edited by Jorge Olmos-Soto

submission deadline 31 Dec 2026 | Viewed by 147 | Submission Open

Keywords: transcriptomics; proteomics; metabolomics; immunomics; host–pathogen interactions; microbiome engineering; next-generation probiotics; recombinant vaccines; epigenetics; molecular diagnostics

(This special issue belongs to the Section Molecular Biology)

Insights in Reproductive Immunology: The Immune Regulation at the Maternal-Fetal Interface in Health and Disease

edited by Mariana Cristina Ferrero and

Andrea M. Canellada

submission deadline 31 Dec 2026 | Viewed by 146 | Submission Open

Keywords: reproductive immunology; maternal–fetal interface; uterine immune cells; extracellular vesicles; gonadal disfunction; sperm-induced inflammation; immune tolerance; immunometabolism; endometriosis; pregnancy complications; microbiome; single-cell and multi-omics; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

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