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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Molecular Insights into Ischemia/Reperfusion: 3rd Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 34 | Submission Open
Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
RNA Regulation and Satellite Cell-Opathies: Molecular Pathogenesis and Therapeutic Frontiers in Neuromuscular Diseases submission deadline 28 Feb 2027 | Viewed by 34 | Submission Open
Keywords: satellite cells; neuromuscular disorders; alternative splicing; satellite cell-opathies; RNA-binding proteins; RNA therapeutics; molecular pathogenesis; myogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immunobiology of Metabolic Regulation and Aging
edited by and Masaki Ohmuraya
submission deadline 28 Feb 2027 | Viewed by 33 | Submission Open
Keywords: age-related diseases; aging vascular endothelial cells; healthy lifespan; organ-specific niche; senescence-associated (SA) immune cells; senescence-associated (SA) metabolism; super-aging society; tertiary lymphoid structures
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Computational Intelligence and Algorithmic Advances in Molecular Materials Science
edited by
submission deadline 28 Feb 2027 | Viewed by 33 | Submission Open
Keywords: molecular modeling; data-driven molecular simulation; molecular materials; computational intelligence; machine learning
(This special issue belongs to the Section Molecular Informatics)
Tumor Microenvironment and Precision Therapeutics: From Biological Insights to Clinical Applications in Solid and Hematological Malignancies
edited by and Eleni D. Kapsali
submission deadline 28 Feb 2027 | Viewed by 32 | Submission Open
Keywords: tumor microenvironment; precision oncology; precision therapeutics; solid tumors; hematological malignancies; tumor heterogeneity; immunotherapy; targeted therapy; cellular therapy; therapeutic resistance; biomarkers; molecular profiling; single-cell sequencing; stromal cells; cancer-associated fibroblasts; extracellular matrix; extracellular vesicles; liquid biopsy; translational oncology; personalized medicine
(This special issue belongs to the Section Molecular Oncology)
Molecular Research and Targeted Therapies of Cardiovascular Diseases
edited by Christos Kourek
submission deadline 28 Feb 2027 | Viewed by 32 | Submission Open
Keywords: cardiovascular diseases; molecular mechanisms; targeted therapy; endothelial progenitor cells; endothelial dysfunction; angiogenesis and vascular repair; cardiac regeneration; biomarkers; precision medicine; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Immune Responses in Infectious Diseases: From Genes and Protein Interactions to Disease Outcomes submission deadline 28 Feb 2027 | Viewed by 32 | Submission Open
Keywords: infectious diseases; immune response; molecular immunology; host–pathogen interactions; immune-related genes; protein–protein interactions; cytokines; biomarkers; molecular mechanisms; disease severity; mortality; genomics; transcriptomics; proteomics; bioinformatics; precision medicine
(This special issue belongs to the Section Molecular Immunology)
Programmable Nucleic Acid Biointerfaces for Molecular Sensing, Diagnostics and Biomedicine
edited by and
submission deadline 28 Feb 2027 | Viewed by 28 | Submission Open
Keywords: DNA nanotechnology; programmable nucleic acid biointerfaces; nucleic acid engineering; molecular diagnostics; biosensing; biointerface engineering; synthetic biology; artificial molecular intelligence; precision biomedicine
(This special issue belongs to the Section Biochemistry)
State-of-the-Art "Molecular Oncology" in Spain
edited by
submission deadline 28 Feb 2027 | Viewed by 28 | Submission Open
Keywords: molecular oncology; molecular pathology; sarcomas; solid tumors; RNA sequencing; DNA sequencing; epigenomics; multidisciplinary team; clinicopathological correlation
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Biomarkers of Central Nervous System Diseases and Disorders: 2nd Edition
edited by and
submission deadline 28 Feb 2027 | Viewed by 27 | Submission Open
Keywords: RNA biomarkers; CNS disorders; autism spectrum disorder; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Advances in the Molecular Pathogenesis, Diagnosis and Treatment of Inherited Metabolic Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 27 | Submission Open
Keywords: inherited metabolic disease; inborn errors of metabolism; newborn screening; mitochondrial disorders; lysosomal storage diseases; congenital disorders of glycosylation; organic acidurias; amino acid disorders; fatty acid oxidation defects; peroxisomal disorders; urea cycle defects
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Neurodegenerative and Neurodevelopmental Disorders: From Molecular Mechanisms to Targeted Therapy
edited by Nobuhiko Miyazawa
submission deadline 28 Feb 2027 | Viewed by 26 | Submission Open
Keywords: Alzheimer’s disease; Parkinson disease; dementia with Lewy body; fronto-temporal lobar degeneration; spino-cerebellar atrophy (SCA); attention-deficit/hyperactivity disorder (ADHD); magnetic resonance imaging (MRI); positron emission computed tomography (PET); single photon computed tomography (SPECT); amylod PET; tau PET; microglial PET; astroglial PET; blood biomarker; cerebrospinal fluid biomarker; deep learning; disease modifying treatment
(This special issue belongs to the Section Molecular Neurobiology)
Inflammation-Driven Cellular Plasticity and Crosstalk in the Tumor Microenvironment
edited by Yasemin Basbinar
submission deadline 28 Feb 2027 | Viewed by 26 | Submission Open
Keywords: inflammatory tumor microenvironment; tumor immunology; cancer metastasis; tumor–immune–stromal interactions; single-cell and spatial omics; cancer cell plasticity; biomarkers; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Applications of Electrochemistry in Medicine and Biotechnology
edited by Michael Klink
submission deadline 28 Feb 2027 | Viewed by 25 | Submission Open
Keywords: electrochemical biosensors; bioelectronics; biomaterials; corrosion inhibition; drug delivery systems; point-of-care diagnostics; implantable devices; bioelectrochemistry; molecular diagnostics; tissue engineering; wearable sensors; organ-on-chip; electrochemical impedance spectroscopy; biomedical applications; biodevices
(This special issue belongs to the Section Biochemistry)
Molecular Interactions in Drug Delivery: From Design to Therapeutic Outcomes
edited by Wenhao Wang
submission deadline 28 Feb 2027 | Viewed by 25 | Submission Open
Keywords: molecular interactions; drug delivery; self-assembly carrier; protein corona; nano–bio interface; targeted delivery; in vivo fate; pharmacokinetics
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Biomarkers and Multi-Omics in Neurological and Neuropsychiatric Disorders submission deadline 28 Feb 2027 | Viewed by 24 | Submission Open
Keywords: molecular biomarkers; multi-omics; translational neuroscience; precision medicine; neurodegeneration; neuropsychiatric disorders; blood biomarkers; cerebrospinal fluid; proteomics; personalized medicine
(This special issue belongs to the Section Molecular Neurobiology)
Genomics and Precision Medicine in Rare Diseases
edited by Angélica Martínez Hernández
submission deadline 28 Feb 2027 | Viewed by 24 | Submission Open
Keywords: rare diseases; genomics; precision medicine; next-generation sequencing; multi-omics; genetic diagnosis; variant interpretation; genotype–phenotype correlations; personalized therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Extracellular Vesicle-Mediated Communication in Tumor Progression and Metastasis
edited by Sze Keong Tey
submission deadline 28 Feb 2027 | Viewed by 24 | Submission Open
Keywords: extracellular vesicles; exosomes; tumor progression; cancer metastasis
(This special issue belongs to the Section Molecular Oncology)
Extracellular Vesicles in Immune Regulation: Mechanisms, Biomarkers, and Therapeutic Applications submission deadline 28 Feb 2027 | Viewed by 22 | Submission Open
Keywords: extracellular vesicles; exosomes; immune regulation; cell-to-cell communication; immunology; biomarkers; immunotherapy; reproductive immunology; tumor immunology; extracellular RNA
(This special issue belongs to the Section Molecular Immunology)
Natural Bioactives: Neural, Metabolic, and Anti-Inflammatory Functions
edited by
submission deadline 28 Feb 2027 | Viewed by 22 | Submission Open
Keywords: natural bioactives; phytochemicals; polyphenols; neuroprotection; metabolism; inflammation; oxidative stress; mitochondria; autophagy; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Advances in Conducting Polymer Hydrogels
edited by
submission deadline 28 Feb 2027 | Viewed by 22 | Submission Open
Keywords: conductive hydrogels; stimuli-responsive hydrogels; biosensors; tissue engineering; drug delivery; biocompatibility
(This special issue belongs to the Section Materials Science)
Nanostructure-Based Biomaterials and Cell Therapies in Regenerative Medicine
edited by Ioannis Tsamesidis
submission deadline 28 Feb 2027 | Viewed by 20 | Submission Open
Keywords: regenerative medicine; nanostructure-based biomaterials; cell therapies; tissue engineering; stem cells; extracellular vesicles; nanomedicine; cell sheets; 3D bioprinting; drug delivery systems
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Interactions Between Microalgae and Other Microorganisms
edited by Mohd Effendy Abd Wahid and
submission deadline 28 Feb 2027 | Viewed by 19 | Submission Open
Keywords: microalgae; phycosphere; algae–bacteria consortia; aquaculture biotechnology; microbial interactions
(This special issue belongs to the Section Molecular Microbiology)
Immunology and Major Histocompatibility Complex (MHC) in Birds
edited by Antonio Arnaiz-Villena
submission deadline 28 Feb 2027 | Viewed by 19 | Submission Open
Keywords: birds; conservation; MHC; immunity; evolution; genetics; taxonomy
(This special issue belongs to the Section Molecular Immunology)
Ambient Environmental Exposures and Chronic Obstructive Pulmonary Disease (COPD)
edited by
submission deadline 28 Feb 2027 | Viewed by 18 | Submission Open
Keywords: COPD; ambient air pollution; particulate matter; oxidative stress; airway inflammation; environmental toxicology; pulmonary biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Pathology and Emerging Therapies for Connective Tissue Diseases
edited by Joanna Kosałka-Węgiel and
submission deadline 28 Feb 2027 | Viewed by 18 | Submission Open
Keywords: systemic lupus erythematosus; systemic sclerosis; dermatomyositis; Sjogren disease; polymyositis; organ damage; pathogenesis; biomarkers; multi-omics; genomic; transcriptomic; metabolomic; treatments; therapeutic
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Tissue Engineering Related Biomaterials: Progress and Challenges, 2nd Edition
edited by Cristina Elena Dinu-Pirvu, and
submission deadline 28 Feb 2027 | Viewed by 18 | Submission Open
Keywords: biomaterials; tissue engineering; scaffold materials; regenerative medicine; cell–material interactions; tissue regeneration; bioactive materials; nanotechnology in tissue engineering; electrospinning; 3D printing; biodegradable materials; growth factors
(This special issue belongs to the Section Materials Science)
Epithelial–Mesenchymal Transition (EMT) in Pathophysiology and Disease submission deadline 28 Feb 2027 | Viewed by 18 | Submission Open
Keywords: epithelial-mesenchymal transition; cell plasticity; mechanotransduction; metabolic reprogramming; phenotypic switching; mechanometabolism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Oral Microbiome and Inflammation
edited by David J. Vigerust
submission deadline 28 Feb 2027 | Viewed by 18 | Submission Open
Keywords: oral microbiome; oral dysbiosis; periodontal inflammation; host–microbe interactions; inflammatory biomarkers; periodontal disease; oral–systemic health; precision diagnostics
(This special issue belongs to the Section Molecular Microbiology)
Nano-Pharmaceutical Modelling and Nano-Drug Delivery: Complexation, Interaction Energies, and Predictive Design submission deadline 28 Feb 2027 | Viewed by 18 | Submission Open
Keywords: nano-drug delivery; nanocarriers; molecular modelling; drug–carrier complexation; interaction energies; binding affinity; host–guest inclusion complexes; pharmaceutical cocrystals; molecular dynamics simulation; machine learning; predictive formulation design
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Pathways Driving Autoimmune Inflammation
edited by
submission deadline 28 Feb 2027 | Viewed by 18 | Submission Open
Keywords: autophagy; autoantibodies; epitopes; autoantigens; mTor; post-translational modification of proteins; citrullination; carbamylation; acetylation; antiphospholipid antibody syndrome; rheumatoid arthritis
(This special issue belongs to the Section Molecular Biology)
Hypoxia: Molecular Mechanism and Health Effects, 2nd Edition submission deadline 28 Feb 2027 | Viewed by 17 | Submission Open
Keywords: hypoxia; inflammation; oxidative stress; metabolic conditions; hypoxia-inducible factors (HIFs); oxidative stress; mitochondrial dysfunction; angiogenesis; metabolic reprogramming; apoptosis
(This special issue belongs to the Section Molecular Biology)
Next-Generation and Third-Generation Sequencing in Life Sciences: Methods and Applications submission deadline 28 Feb 2027 | Viewed by 15 | Submission Open
Keywords: next-generation sequencing; third-generation sequencing; NGS; long-read sequencing; short-read sequencing; whole-genome sequencing; transcriptomics; RNA sequencing; metagenomics; metatranscriptomics; microbiome; genome assembly; bioinformatics; sequencing technologies; multi-omics; genomic analysis; molecular biology; life sciences
(This special issue belongs to the Section Molecular Informatics)
Molecular Mechanism and Therapy of Respiratory Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 14 | Submission Open
Keywords: respiratory diseases; molecular mechanisms; precision medicine; airway inflammation; pulmonary fibrosis; COPD; asthma; cystic fibrosis; biomarkers; drug discovery; organoids; therapeutic development
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Translational Research and Therapeutic Strategies for Peritoneal Malignancies
edited by
submission deadline 28 Feb 2027 | Viewed by 14 | Submission Open
Keywords: peritoneal metastases; surgical oncology; cytoreductive surgery; HIPEC; PIPAC; intraperitoneal therapy; translational research; precision oncology; drug delivery; cancer treatment
(This special issue belongs to the Section Molecular Oncology)
Oral‑Gut Microbiota Crosstalk: Molecular Mechanisms, Stress Responses and Systemic Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 13 | Submission Open
Keywords: oral-gut axis; oral microbiota; oral biofilm; periodontal pathogens
(This special issue belongs to the Section Molecular Microbiology)
Hereditary Cancer Genomics in the Era of Next-Generation Sequencing: From Variant Discovery to Precision Prevention
edited by and Rosa Maria Alvarez-Gomez
submission deadline 28 Feb 2027 | Viewed by 13 | Submission Open
Keywords: hereditary cancer; cancer predisposition; germline variants; pathogenic variants; next-generation sequencing; multigene panel testing; variant interpretation; cancer genomics; precision oncology; genetic testing; hereditary cancer syndromes; molecular diagnostics; germline variants; molecular oncology; precision prevention; translational genomics
(This special issue belongs to the Section Molecular Genetics and Genomics)
PI3K/AKT/mTOR: The Central Processor in Cancer
edited by Marcia Bellon
submission deadline 28 Feb 2027 | Viewed by 12 | Submission Open
Keywords: mTOR; PI3K; AKT; drug targeting; therapeutic resistance; oncology metabolism; cell signaling
(This special issue belongs to the Section Molecular Biology)
Molecular Research Progress in Malignant Hyperthermia Susceptibility
edited by Helga Cristina Almeida Da Silva
submission deadline 28 Feb 2027 | Viewed by 11 | Submission Open
Keywords: anaesthesia; calcium signalling; human genetics; malignant hyperthermia; muscle disorders; ryanodine receptor
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Cellular Immunotherapies
edited by Maria Elena Candela
submission deadline 28 Feb 2027 | Viewed by 10 | Submission Open
Keywords: cellular immunotherapy; adoptive cell therapy; engineered immune cells; CAR-T cells; natural killer cells; macrophage therapy; immune regulation; gene editing; regenerative medicine; clinical translation
(This special issue belongs to the Section Molecular Immunology)
Drug Delivery Systems of Curcumin and Its Therapeutic Applications
edited by and
submission deadline 28 Feb 2027 | Viewed by 9 | Submission Open
Keywords: bioavailability; curcumin; drug delivery; nanocarriers; nanomedicine; nanoparticles; pharmacokinetics
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms and Therapies of Myeloid Leukaemia, 3rd Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 9 | Submission Open
Keywords: acute leukemia; myeloid leukemia; pediatric leukemia; adult leukemia; targeted therapy; antigens
(This special issue belongs to the Section Molecular Oncology)
Advanced Functional Luminescent Materials
edited by Arkadiusz Matwijczuk
submission deadline 28 Feb 2027 | Viewed by 8 | Submission Open
Keywords: room-temperature phosphorescence (RTP); ultralong RTP and afterglow; delayed fluorescence and long-lived luminescence; triplet-state photophysics; intersystem crossing (ISC) and reverse intersystem crossing (RISC); polymer matrices and polymer-based luminescent materials; sustainable and bio-derived luminescent materials; molecular rigidification and restriction of intramolecular motion (RIM); aggregation-induced emission (AIE) and aggregation-enhanced emission (AEE); molecular aggregation and self-assembly; excited-state proton transfer (ESIPT/ESPT); charge-transfer processes (ICT, TICT); excited-state dynamics; molecular packing and intermolecular interactions; crystalline, amorphous, supramolecular, and hybrid luminescent materials; fluorescence and phosphorescence spectroscopy; time-resolved and time-gated spectroscopy; DFT and TD-DFT calculations; optical sensing and time-gated bioimaging; anti-counterfeiting and information encryption; functional photonic and optoelectronic materials
(This special issue belongs to the Section Materials Science)
Recent Advances in Nanoelectronics and Associated Applications submission deadline 28 Feb 2027 | Viewed by 8 | Submission Open
Keywords: nanoelectronics; low-dimensional materials; semiconductor devices; neuromorphic; quantum; nanosensors; nanophotonics; energy-efficient circuits; healthcare; environmental monitoring; energy systems; next-generation computing
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Biomarkers in Cancers: Advances and Challenges, 3rd Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 5 | Submission Open
Keywords: cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Evolution in Upper Aerodigestive Tract Tumors: From Carcinogenesis to Precision Oncology
edited by and Pedro Nicolau Neto
submission deadline 28 Feb 2027 | Viewed by 4 | Submission Open
Keywords: upper aerodigestive tract carcinogenesis; molecular alterations in upper aerodigestive tract tumors; cancer prevention and early diagnosis; molecular profiling and biomarkers; tumor microenvironment and metastasis; genomic and epigenetic alterations; molecular mechanisms of tumor progression; therapeutic resistance; targeted therapy and immunotherapy; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Advances and Perspectives in Mass Spectrometry for Biomaterial Analysis
edited by
submission deadline 1 Mar 2027 | Viewed by 370 | Submission Open
Keywords: mass spectrometry; biopolymers; biomaterials; compositional and structural analysis; surface and interface analysis; biofunctionalization; industrial and clinical applications
(This special issue belongs to the Section Materials Science)
Molecular Breeding for Abiotic Stress Tolerance in Crops (Second Edition)
edited by
submission deadline 20 Mar 2027 | 9 articles | Viewed by 15985 | Submission Open
Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes
(This special issue belongs to the Section Molecular Plant Sciences)
Intestinal Diseases and Gut Microbiota
edited by
submission deadline 20 Mar 2027 | 2 articles | Viewed by 5480 | Submission Open
Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Conventional Tree Breeding: Integrating Phenotypic Selection, Genetic Gain, and Sustainable Forest Management
edited by
submission deadline 20 Mar 2027 | 1 articles | Viewed by 3869 | Submission Open
Keywords: forest trees; genetic breeding; conventional tree breeding; forest management; forest tree varieties; modern molecular technology; genetic engineering
(This special issue belongs to the Section Molecular Plant Sciences)
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