E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Zinc Biology 2019"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 25 November 2019

Special Issue Editors

Guest Editor
Prof. Dr. Toshiyuki Fukada

Molecular and Cellular Physiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan
Website | E-Mail
Interests: zinc signaling; Slc39a/ZIP and Slc30a/ZnT zinc transporters; signal transduction; physiology; disease
Guest Editor
Assoc. Prof. Dr. Taiho Kambe

Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
Website | E-Mail
Interests: zinc transporter; zinc metabolism; cellular biochemistry; metal enzymes; metal biology; absorption of essential trace elements; nutrient deficiency (Fe, Zn, Cu)

Special Issue Information

Dear Colleagues,

The essential trace element zinc plays indispensable roles in multiple cellular processes. It regulates a great number of protein functions, including transcription factors, enzymes, adapters, and growth factors as a structural and/or catalytic factor. Zinc homeostasis is regulated by metal transporters and cation channels, and recent studies have highlighted zinc as an intra- and intercellular signaling mediator, “zinc signal”, which can regulate cellular signaling pathways and biological processes.

This Special Issue focuses on crucial roles of zinc homeostasis and zinc signaling in biology as regards the molecular and physiological bases, addressing the future directions and questions. Because there is growing interest and attention in the physiopathological contribution of zinc homeostasis and zinc signaling, we believe this Special Issue will provide very timely information on it and thus should appeal to a wide range of readers.

The International Society for Zinc Biology Conference 2019 (ISZB-2019, http://www.iszb2019.com) will be held in Kyoto, Japan, 9–13 September, 2019. All attendees presenting a paper at this conference are welcome to submit a manuscript for publication (Deadline: 25 November 2019). For further information, please contact the Editorial Office ([email protected] or [email protected]).

Prof. Toshiyuki Fukada
Prof. Taiho Kambe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Zinc
  • Zinc biology
  • Zinc transporters
  • Metallothionein
  • receptors and channels
  • physiology
  • disease

Related Special Issue

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:


Open AccessArticle Zinc Supplementation Stimulates Red Blood Cell Formation in Rats
Int. J. Mol. Sci. 2018, 19(9), 2824; https://doi.org/10.3390/ijms19092824
Received: 9 August 2018 / Revised: 5 September 2018 / Accepted: 5 September 2018 / Published: 18 September 2018
PDF Full-text (2919 KB) | HTML Full-text | XML Full-text | Supplementary Files
In rats, mice, and humans, it is known that zinc deficiency may be related to anemia, and zinc supplementation influences hemoglobin production. Our previous studies indicate that in fish, zinc supplementation stimulates red blood cell (RBC) formation (erythropoiesis). However, it is not clear [...] Read more.
In rats, mice, and humans, it is known that zinc deficiency may be related to anemia, and zinc supplementation influences hemoglobin production. Our previous studies indicate that in fish, zinc supplementation stimulates red blood cell (RBC) formation (erythropoiesis). However, it is not clear whether the mechanism of zinc-induced erythropoiesis stimulation in fish also occurs in rats. We induced anemia in rats using phenylhydrazine (PHZ) and injected either saline or ZnSO4 solution. We found that an appropriate amount of zinc stimulated erythropoiesis in the PHZ-induced anemic rats. The effects of ZnSO4 injection were dose-dependent. When the concentration of ZnSO4 was higher than 2.8 mg zinc/kg body weight, the RBC level of the anemic rats increased from 60 ± 7% to 88 ± 10% that of the normal rats in two days. Rat bone marrow cells with or without ZnCl2 supplementation were cultured in suspension in vitro. In the cell culture when the zinc concentration was at 0.3 mM, a 1.6-fold proliferation of nascent immature reticulocytes (new RBCs) was observed after one day. In the rat blood, zinc was combined with serum transferrin to induce erythropoiesis. The stimulation of RBC formation by zinc appears to be common among different animals. Full article
(This article belongs to the Special Issue Zinc Biology 2019)

Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Editorial: Toshiyuki Fukada, Taiho Kambe

1 (Zinc sensor): Christoph Fahrni

2 (Neurology 1: neuron): Ashely Bush, Elias Aizenman

3 (Neurology 2: memory): Atsushi Takeda, Jae-Young Koh

4 (Immunology and inflammation): Lothar Rink, Daren Knoell

5 (Biochemistry): Wolfgang Maret, Dax Fu

6 (Cell biology and cancer): Kathy Taylor, Israel Sekler

7 (Diabetes): Hiroyuki Yasui, Liping Huang

8 (Zinc therapy): Hiroko Kodama, Mitsuhiko Moriyama

9 (Meeting report): Toshiyuki Fukada, Taiho Kambe

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top