Next Article in Journal
Bioinformatics Approaches to the Understanding of Molecular Mechanisms in Antimicrobial Resistance
Next Article in Special Issue
Japan’s Practical Guidelines for Zinc Deficiency with a Particular Focus on Taste Disorders, Inflammatory Bowel Disease, and Liver Cirrhosis
Previous Article in Journal
Molecular Evidences for the Interactions of Auxin, Gibberellin, and Cytokinin in Bent Peduncle Phenomenon in Rose (Rosa sp.)
Previous Article in Special Issue
Zinc Homeostasis in Bone: Zinc Transporters and Bone Diseases
Open AccessReview

Zinc Finger Proteins in the Human Fungal Pathogen Cryptococcus neoformans

by Yuan-Hong Li 1,2 and Tong-Bao Liu 1,2,*
1
State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, China
2
Chongqing Key Laboratory of Microsporidia Infection and Prevention, Southwest University, Chongqing 400715, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(4), 1361; https://doi.org/10.3390/ijms21041361
Received: 1 December 2019 / Revised: 13 February 2020 / Accepted: 13 February 2020 / Published: 18 February 2020
(This article belongs to the Special Issue Zinc Biology 2019)
Zinc is one of the essential trace elements in eukaryotes and it is a critical structural component of a large number of proteins. Zinc finger proteins (ZNFs) are zinc-finger domain-containing proteins stabilized by bound zinc ions and they form the most abundant proteins, serving extraordinarily diverse biological functions. In recent years, many ZNFs have been identified and characterized in the human fungal pathogen Cryptococcus neoformans, a fungal pathogen causing fatal meningitis mainly in immunocompromised individuals. It has been shown that ZNFs play important roles in the morphological development, differentiation, and virulence of C. neoformans. In this review, we, first, briefly introduce the ZNFs and their classification. Then, we explain the identification and classification of the ZNFs in C. neoformans. Next, we focus on the biological role of the ZNFs functionally characterized so far in the sexual reproduction, virulence factor production, ion homeostasis, pathogenesis, and stress resistance in C. neoformans. We also discuss the perspectives on future function studies of ZNFs in C. neoformans. View Full-Text
Keywords: zinc finger proteins; Cryptococcus neoformans; fungal development; sexual reproduction; virulence zinc finger proteins; Cryptococcus neoformans; fungal development; sexual reproduction; virulence
Show Figures

Figure 1

MDPI and ACS Style

Li, Y.-H.; Liu, T.-B. Zinc Finger Proteins in the Human Fungal Pathogen Cryptococcus neoformans. Int. J. Mol. Sci. 2020, 21, 1361.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop