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Special Issue "Retinal Degeneration: From Pathophysiology to Therapeutic Approaches"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2019).
Loss of vision due to retinal degeneration can have monogenic or multifactorial causes. There is an urgent search for cures, treatments and prevention for children as well as adults affected by retinitis pigmentosa, age-related macular degeneration, Usher syndrome and other retinal degenerative diseases. A first retinal gene therapy medicine has recently been approved by regulatory agencies and other studies are ongoing in the clinic, but there are many more retinal disease genes without an available medicine. The retina is well accessible through image-guided surgical intervention including gene therapy and the transplantation of retinal cells. Neural retina and retinal pigment epithelium (RPE) can be generated from induced pluripotent stem cells (hiPSC) and used for pre-clinical studies.
This issue of the International Journal of Molecular Sciences will focus on recent insights in “Retinal Degeneration: From Pathophysiology to Therapeutic Approaches”, including new insights into hereditary disease, human and animal retinal pathology due to gene mutations, retinal inflammation, retinal gene therapy, hiPSC-derived neural retina and RPE, natural history studies on patients, pre-and clinical gene therapy, animal models for hereditary retinal dystrophy, retinal imaging, and submissions dealing with these topics are welcome.
Assoc. Prof. Dr. Jan Wijnholds
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- hereditary retinal disease
- retinal inflammation
- retinal gene augmentation, editing, optogenetics and splice modulation therapy
- natural history studies of the retina
- human iPSC-derived retina and retinal pigment epithelium
- retinal iPSC-derived cell therapy
- retinal pathology
- pre- and clinical gene therapy
- animal models for retinal dystrophy
- retinal imaging