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Clustered DNA Damages induced by 0.5 to 30 eV Electrons
Open AccessReview

Reaction of Electrons with DNA: Radiation Damage to Radiosensitization

Department of Chemistry, Oakland University, Rochester, MI 48309, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(16), 3998;
Received: 11 July 2019 / Revised: 1 August 2019 / Accepted: 12 August 2019 / Published: 16 August 2019
(This article belongs to the Special Issue Radiation-Induced Damage to DNA)
PDF [4841 KB, uploaded 19 August 2019]


This review article provides a concise overview of electron involvement in DNA radiation damage. The review begins with the various states of radiation-produced electrons: Secondary electrons (SE), low energy electrons (LEE), electrons at near zero kinetic energy in water (quasi-free electrons, (eqf)) electrons in the process of solvation in water (presolvated electrons, epre), and fully solvated electrons (eaq). A current summary of the structure of eaq, and its reactions with DNA-model systems is presented. Theoretical works on reduction potentials of DNA-bases were found to be in agreement with experiments. This review points out the proposed role of LEE-induced frank DNA-strand breaks in ion-beam irradiated DNA. The final section presents radiation-produced electron-mediated site-specific formation of oxidative neutral aminyl radicals from azidonucleosides and the evidence of radiosensitization provided by these aminyl radicals in azidonucleoside-incorporated breast cancer cells. View Full-Text
Keywords: quasi-free electron; solvated electron; low energy electrons; ion-beam radiation; radiosensitization quasi-free electron; solvated electron; low energy electrons; ion-beam radiation; radiosensitization

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kumar, A.; Becker, D.; Adhikary, A.; Sevilla, M.D. Reaction of Electrons with DNA: Radiation Damage to Radiosensitization. Int. J. Mol. Sci. 2019, 20, 3998.

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