Reaction of Electrons with DNA: Radiation Damage to Radiosensitization
AbstractThis review article provides a concise overview of electron involvement in DNA radiation damage. The review begins with the various states of radiation-produced electrons: Secondary electrons (SE), low energy electrons (LEE), electrons at near zero kinetic energy in water (quasi-free electrons, (e−qf)) electrons in the process of solvation in water (presolvated electrons, e−pre), and fully solvated electrons (e−aq). A current summary of the structure of e−aq, and its reactions with DNA-model systems is presented. Theoretical works on reduction potentials of DNA-bases were found to be in agreement with experiments. This review points out the proposed role of LEE-induced frank DNA-strand breaks in ion-beam irradiated DNA. The final section presents radiation-produced electron-mediated site-specific formation of oxidative neutral aminyl radicals from azidonucleosides and the evidence of radiosensitization provided by these aminyl radicals in azidonucleoside-incorporated breast cancer cells. View Full-Text
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Kumar, A.; Becker, D.; Adhikary, A.; Sevilla, M.D. Reaction of Electrons with DNA: Radiation Damage to Radiosensitization. Int. J. Mol. Sci. 2019, 20, 3998.
Kumar A, Becker D, Adhikary A, Sevilla MD. Reaction of Electrons with DNA: Radiation Damage to Radiosensitization. International Journal of Molecular Sciences. 2019; 20(16):3998.Chicago/Turabian Style
Kumar, Anil; Becker, David; Adhikary, Amitava; Sevilla, Michael D. 2019. "Reaction of Electrons with DNA: Radiation Damage to Radiosensitization." Int. J. Mol. Sci. 20, no. 16: 3998.
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