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Open AccessArticle

Radio-Enhancing Properties of Bimetallic Au:Pt Nanoparticles: Experimental and Theoretical Evidence

1
Institut des Sciences Moléculaires d’Orsay (UMR 8214) CNRS, Université Paris-Saclay, Université Paris Sud, 91405 Orsay, France
2
Cátedras CONACyT, Universidad Autónoma de San Luis Potosí, Facultad de Ciencias Químicas, Av. Dr. Manuel Nava 6, Zona Universitaria, San Luis Potosí 78210, S.L.P., Mexico
3
Instituto de Física Fundamental, Consejo Superior de Investigaciones Científicas (CSIC), Serrano 113-bis, 28006 Madrid, Spain
4
Institut de Chimie Moléculaire et des Matériaux d’Orsay (UMR 8182) CNRS, Université Paris Saclay, Université Paris Sud, 91405 Orsay, France
5
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Avda. Complutense 22, 28040 Madrid, Spain
6
Laboratoire de Chimie Physique (UMR 8000) CNRS, Université Paris Saclay, Université Paris Sud, 91405 Orsay, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(22), 5648; https://doi.org/10.3390/ijms20225648
Received: 11 September 2019 / Revised: 28 October 2019 / Accepted: 6 November 2019 / Published: 12 November 2019
(This article belongs to the Special Issue Radiation-Induced Damage to DNA)
The use of nanoparticles, in combination with ionizing radiation, is considered a promising method to improve the performance of radiation therapies. In this work, we engineered mono- and bimetallic core-shell gold–platinum nanoparticles (NPs) grafted with poly (ethylene glycol) (PEG). Their radio-enhancing properties were investigated using plasmids as bio-nanomolecular probes and gamma radiation. We found that the presence of bimetallic Au:Pt-PEG NPs increased by 90% the induction of double-strand breaks, the signature of nanosize biodamage, and the most difficult cell lesion to repair. The radio-enhancement of Au:Pt-PEG NPs were found three times higher than that of Au-PEG NPs. This effect was scavenged by 80% in the presence of dimethyl sulfoxide, demonstrating the major role of hydroxyl radicals in the damage induction. Geant4-DNA Monte Carlo simulations were used to elucidate the physical processes involved in the radio-enhancement. We predicted enhancement factors of 40% and 45% for the induction of nanosize damage, respectively, for mono- and bimetallic nanoparticles, which is attributed to secondary electron impact processes. This work contributed to a better understanding of the interplay between energy deposition and the induction of nanosize biomolecular damage, being Monte Carlo simulations a simple method to guide the synthesis of new radio-enhancing agents. View Full-Text
Keywords: core-shell gold–platinum nanoparticles; radio-enhancement; radiosensitization; complex damage; Geant4-DNA; Monte Carlo simulation core-shell gold–platinum nanoparticles; radio-enhancement; radiosensitization; complex damage; Geant4-DNA; Monte Carlo simulation
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MDPI and ACS Style

Salado-Leza, D.; Traore, A.; Porcel, E.; Dragoe, D.; Muñoz, A.; Remita, H.; García, G.; Lacombe, S. Radio-Enhancing Properties of Bimetallic Au:Pt Nanoparticles: Experimental and Theoretical Evidence. Int. J. Mol. Sci. 2019, 20, 5648.

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