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Special Issue "Molecular Research on Stress Response and Ocular Homeostasis"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 10 May 2020.

Special Issue Editor

Assoc. Prof. Toshihide Kurihara
E-Mail Website
Guest Editor
Laboratory of Photobiology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582 Tokyo, Japan
Interests: retina; hypoxia response; myopia; optogenetics
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Special Issue Information

Dear Colleagues,

Stress response is a fundamental cellular reaction contributing to developmental processes, tissue homeostasis, and organ pathogenesis. Physiologically, individual organs maintain their homeostasis, reacting to various stresses such as hypoxia, inflammation, and starvation. The eye is the organ which specifically exists in order to receive light and convert it to a signal. Thus, individual cells protect their functions from the distinctive microenvironment in respective ocular components including the cornea, the crystalline lens, the retina, and the uvea. Not only intraocular systems but also inter-organ systems such as the eye–gut axis utilize cellular stress response to maintain local and systemic homeostasis. Molecular components including, but not limited to, stress-responsive transcriptional factors such as hypoxia-inducible factors (HIFs), nuclear factor erythroid 2-related factor 2 (Nrf2), and nuclear factor-kappa B (NF-kB) have been revealed to play a critical role in cellular stress response. Dysfunction or rather ectopic activation of molecules in charge of cellular stress response can be observed in the pathophysiological process of multiple ocular components. This Special Issue will focus on ocular stress response in molecular, cellular, local, and systemic levels. The response and related molecules are conserved between species; therefore, the scope includes a large extent from the basic biological sciences to human diseases.

Assoc. Prof. Toshihide Kurihara
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Hypoxia response
  • Oxidative stress
  • Energy homeostasis
  • Light exposure

Published Papers (1 paper)

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Open AccessArticle
Effects of Hyperoxia on the Refraction in Murine Neonatal and Adult Models
Int. J. Mol. Sci. 2019, 20(23), 6014; https://doi.org/10.3390/ijms20236014 - 29 Nov 2019
Cited by 1
Whether hyperoxia affects the refraction in neonatal and adult mice is unknown. The mice exposed to 85% oxygen at postnatal 8 days (P8d) for 3 days and the mice exposed to normal air were assigned to the neonatal hyperoxia and normoxia groups, respectively. [...] Read more.
Whether hyperoxia affects the refraction in neonatal and adult mice is unknown. The mice exposed to 85% oxygen at postnatal 8 days (P8d) for 3 days and the mice exposed to normal air were assigned to the neonatal hyperoxia and normoxia groups, respectively. The refraction, the corneal curvature radius (CR) and the axial length (AL) were measured at P30d and P47d. Postnatal 6 weeks (P6w) adult mice were divided into the adult hyperoxia and normoxia groups. These parameters were measured before oxygen exposure, after 1 and 6 weeks, and every 7 weeks. The lens elasticity was measured at P7w and P26w by enucleation. The neonatal hyperoxia group showed a significantly larger myopic change than the neonatal normoxia group (P47d −6.56 ± 5.89 D, +4.11 ± 2.02 D, p < 0.001), whereas the changes in AL were not significantly different (P47d, 3.31 ± 0.04 mm, 3.31 ± 0.05 mm, p = 0.852). The adult hyperoxia group also showed a significantly larger myopic change (P12w, −7.20 ± 4.09 D, +7.52 ± 2.54 D, p < 0.001). The AL did not show significant difference (P12w, 3.44 ± 0.03 mm, 3.43 ± 0.01 mm, p = 0.545); however, the CR in the adult hyperoxia group was significantly smaller than the adult normoxia group (P12w, 1.44 ± 0.03 mm, 1.50 ± 0.03 mm, p = 0.003). In conclusion, hyperoxia was demonstrated to induce myopic shift both in neonatal and adult mice, which was attributed to the change in the CR rather than the AL. Elucidation of the mechanisms of hyperoxia and the application of this result to humans should be carried out in future studies. Full article
(This article belongs to the Special Issue Molecular Research on Stress Response and Ocular Homeostasis)
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